Reds vs Padres Prediction 9/1/26 MLB Picks Today
San Diego Padres (73-65) vs. Cincinnati Reds (65-73)
September 1, 2026 6:40 pm EDT
The Line: Cincinnati Reds 125 / San Diego Padres -134; Over/Under: 9.5
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In this article we will formulate a Reds vs Padres prediction for this MLB game on Tuesday, September 1st at Great American Ball Park in Cincinnati, Ohio. Let’s take a look at the prediction for this MLB matchup.
Cincinnati Reds Betting Preview
The Cincinnati Reds are 65-73 this year after they lost game one by a score of 0-5 last night. Cincinnati allowed four runs in the fourth inning and never woke up at the plate in the shutout loss. The Reds recorded five hits and they committed one error in the game, while they were led by Stephenson, who went 1-3 with a walk. Singer allowed 10 hits and four earned runs over 4.1 innings for the loss, while Johnson allowed one earned run in relief. Prior to this series, Cincinnati won two out of three against the Cubs, but lost two out of three against the Giants before that.
This season, Cincinnati has a 4.67 ERA with a 1.43 WHIP and a .252 opponent batting average, while they have scored 570 runs with a .228 batting average and a .307 on base percentage. Sal Stewart has led the Reds with 31 home runs and 105 RBIs, while Elly De La Cruz has added 21 home runs and 60 RBIs. The projected starting pitcher for Cincinnati is Nick Lodolo, who is 3-3 with a 5.24 ERA and a 1.54 WHIP over 79.0 innings pitched this year.
San Diego Padres Betting Preview
The San Diego Padres are 73-65 this season after they won game one by a score of 5-0 on Monday night. San Diego scored four runs in the fourth inning and one more in the seventh in the win. The Padres recorded 15 hits in the game and they were led by Bogaerts, who went 1-5 with two RBIs. King allowed four hits and zero earned runs over 6.0 innings for the win, while Hart threw two scoreless innings in relief. Prior to this series, San Diego lost all three against the Rays and two out of three against the Pirates.
This season, San Diego has a 3.91 ERA with a 1.29 WHIP and a .241 opponent batting average, while they have scored 588 runs with a .238 batting average and a .315 on base percentage. Manny Machado has led the Padres with 24 home runs and 74 RBIs, while Gavin Sheets has added 16 home runs and 46 RBIs. The projected starting pitcher for San Diego is Randy Vasquez, who is 10-6 with a 4.02 ERA and a 1.28 WHIP over 123.0 innings pitched this season.
Why the Cincinnati Reds will win
- The Reds have won each of their last six night games at Great American Ball Park following a loss.
- The Padres have lost four of their last five games as favorites against NL Central opponents following a win.
- The Padres have failed to cover the run line in each of their last seven games as favorites against NL Central opponents following a win.
- The Reds have covered the run line in each of their last five games as home underdogs against NL West opponents following a loss.
Why the San Diego Padres will win
- The Padres have won each of their last four road games against NL Central opponents that held a losing record.
- The Reds have lost four of their last five games against NL West opponents.
- The Padres have covered the run line in each of their last nine road games against the Reds following a road win.
- The Reds have failed to cover the run line in nine of their last 10 games against the Padres following a home loss.
- The Reds have trailed after 3 innings in three of their last four games.
- The Reds have lost the first inning in three of their last four games.
- The Reds have trailed after 5 innings in each of their last six home games.
Total Runs Facts
- Each of the Padres’ last eight games against NL opponents have gone UNDER the total runs line.
- Each of the Reds’ last four home games against NL West opponents have gone UNDER the total runs line.
- There has been no run scored during the first inning in each of the Padres’ last seven games against NL Central opponents.
- There has been no run scored during the first inning in each of Nick Lodolo’s last six home appearances as a starter.
Cincinnati Reds Player Prop Facts
- Sal Stewart has hit a home run in three of the Reds’ last four games.
- Nick Lodolo has recorded five or more strikeouts in each of his last three home appearances against NL West opponents.
- Tyler Stephenson has recorded at least one hit in each of the Reds’ last six games against opponents that held a winning record.
- Sal Stewart ranks 9th in the league in Home Runs (31) this season.
San Diego Padres Player Prop Facts
- Fernando Tatis Jr. has hit at least one home run in three of the Padres’ last seven games as road favorites.
- Randy Vasquez has recorded a win in each of his last four appearances against NL Central opponents.
- Samad Taylor has recorded at least one hit in each of his last 11 appearances against opponents that held a losing record.
- Fernando Tatis Jr. ranks T6th in the league in Hits (150) this season.
Matchup/League Facts
- The Reds rank 29th in the league for hits this season (1046).
- The Reds rank 29th in the league for batting average this season (.228).
- The Padres rank T4th in the league for steals this season (135).
- The Padres rank T26th in the league for triples this season (12).
Reds vs Padres Prediction
San Diego snapped their small losing streak with a win on Monday night, but they allowed 21 runs in the three games prior to that. The Padres are 32-37 on the road this year, while the Reds are 32-37 at home. Cincinnati has won three of their last five games, but they have allowed 5, 5, 17, 8, and 9 in their last five. The Reds are starting Lodolo, who has allowed 4+ earned runs in three of his last four starts, while Vasquez has allowed two earned runs or fewer in four of his last five outings. Take the Padres to win again here.