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Reds vs Pirates Prediction 4/1/26 MLB Picks Today

Pittsburgh Pirates (2-3) vs. Cincinnati Reds (3-2)
April 1, 2026 12:40 pm EDT
The Line: Cincinnati Reds 135 / Pittsburgh Pirates -163; Over/Under: 7.5
(Get latest betting odds)

In this article we will formulate a Reds vs Pirates prediction for this MLB game on Wednesday, April 1st at Great American Ball Park in Cincinnati, Ohio. Let’s take a look at the prediction for this MLB matchup. 

Cincinnati Reds Betting Preview

The Cincinnati Reds are 3-2 this season after they split the first two games in this series by scores of 2-0 and 3-8. In their game two loss, Cincinnati only managed one run in the first seven innings, which was not enough to stay close. The Reds recorded six hits in the game and they were led by De La Cruz and Stewart, who both hit solo home runs. Williamson allowed six hits and six earned runs over 4.2 innings for the loss, while Johnson allowed two earned runs in relief. 

This season, Cincinnati has a 3.45 ERA with a 1.30 WHIP and a .228 opponent batting average, while they have scored 14 runs with a .193 batting average and a .311 on base percentage. Eugenio Suarez has led the Reds with one home run and four RBIs, while Sal Stewart has added two home runs and three RBIs. The projected starting pitcher for Cincinnati is Andrew Abbott, who is 0-0 with a 0.00 ERA and a 1.33 WHIP over 6.0 innings pitched this season. 

Pittsburgh Pirates Betting Preview

The Pittsburgh Pirates are 2-3 this year after they won game two by a score of 8-3 on Tuesday night. Pittsburgh scored the first five runs in the game and they were able to cruise to the easy win in the final few innings. The Pirates recorded eight hits and they committed one error in the game, while they were led by Cruz and O’Hearn, who both had three RBIs. Chandler allowed zero hits and zero earned runs over 4.1 innings in the no decision, while Ramirez picked up the win and Santana got a hold. 

This season, Pittsburgh has a 3.80 ERA with a 1.44 WHIP and a .220 opponent batting average, while they have scored 21 runs with a .227 batting average and a .305 on base percentage. Brandon Lowe has led the Pirates with three home runs and four RBIs, while Ryan O’Hearn has added two home runs and six RBIs. The projected starting pitcher for Pittsburgh is Paul Skenes, who is 0-1 with a 67.50 ERA and a 9.00 WHIP over 0.2 innings pitched this year. 

Why the Cincinnati Reds will win

  • The Reds have won each of their last 11 day games following a home loss.
  • The Pirates have lost each of their last four games as road favorites following a win.
  • The Reds have covered the run line in each of their last nine games as home underdogs against National League opponents following a loss.
  • The Pirates have failed to cover the run line in seven of their last eight games as favorites against the Reds following a road win.
  • The Reds have led after 5 innings in four of their last five day games against NL Central opponents.

Why the Pittsburgh Pirates will win

  • The Pirates have won each of their last seven Wednesday games against the Reds.
  • The Reds have lost each of their last seven Wednesday day home games.
  • The Reds have failed to cover the run line in each of their last six games against the Pirates following a loss.
  • The road team has covered the run line in five of the last six games between the Pirates and Reds.
  • The Reds have lost the first inning in three of their last four day games against National League opponents that held a losing record.
  • The Reds have trailed after 5 innings in each of their last four games as underdogs against National League opponents.

Total Runs Facts

  • Seventeen of the Reds’ last 19 day games against National League opponents have gone UNDER the total runs line.
  • Four of the Pirates’ last five games after playing the previous day have gone UNDER the total runs line.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Reds’ last 10 games against NL Central opponents.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Pirates’ last 10 games as road favorites against NL Central opponents.

Cincinnati Reds Player Prop Facts

  • Elly De La Cruz has recorded at least one hit in each of the Reds’ last 11 games as underdogs against NL Central opponents.
  • Elly De La Cruz has hit a home run in each of the Reds’ last two games as underdogs against NL Central opponents.

Pittsburgh Pirates Player Prop Facts

  • Bryan Reynolds has hit a home run in each of the Pirates’ last two games as road favorites against the Reds.
  • Bryan Reynolds has recorded at least one hit in each of the Pirates’ last eight games as favorites against the Reds.

Reds vs Pirates Prediction 

Pittsburgh comes into this matchup after winning two of their last three games and they will look for their first series win here. The Pirates are starting Skenes, who was the victim of some awful fielding in his first start, where he didn’t even make it out of the first. Cincinnati has won three of their last four games, but they have scored three runs or fewer in four of their five games. The Reds are starting Abbott, who pitched very well in his first outing, but I think Skenes is going to bounce back in a big way. Take the Pirates -1.5 here. 

David Racey's Free Pick: Pirates -1.5

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David Racey

David started writing about sports in 2015, but sports has been his passion for as long as he can remember. David spends most of his free time watching pretty much anything sports related from Baseball to Tennis and everything in between. David likes to analyze statistics and recent results to form an unbiased opinion on whatever game he is breaking down. Follow David on Twitter at @itsyerboi41

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