Reds vs Twins Prediction 4/17/26 MLB Picks Today

In this article, we will formulate a Reds vs Twins Prediction for this MLB matchup on Friday, April 17^th in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Minnesota Twins Preview

The Minnesota Twins have a 11-8 record this season and are sitting in the first place of the AL Central. They have a 7-3 home record and are coming off a 5-9 home loss against the Red Sox. Their previous three games were a 6-0 and a 13-6 home win to the Red Sox, and an 8-2 road win against the Blue Jays.

The Twins have a .232 batting average this season, .333 OBP and .399 Slugging percentage. Minnesota’s pitching staff has a 4.26 ERA and 1.41 WHIP. Victor Caratini is the team’s best hitter with a .259 batting average. Josh Bell leads the team in RBI with 14, also adding a team‑high 3 home runs.

Joe Ryan (R) is the projected starting pitcher for the Twins, and he has a 2-1 record, 3.80 ERA and 0.98 WHIP.

Cincinnati Reds Preview

The Cincinnati Reds have a 11-8 record this season and are sitting in the first place of the NL Central. They have a 5-2 away record and are coming off a 0-3 home loss against the Giants. Their previous three games were an 8-3 and a 2-1 home win to the Giants, and a 6-9 home loss to the Angels.

The Reds have a .200 batting average this season, .299 OBP and .333 Slugging percentage. Cincinnati’s pitching staff has a 3.61 ERA and 1.34 WHIP. Sal Stewart is the team’s best hitter with a .303 batting average, also leading the team in RBI with 17 and adding a team‑high 7 home runs.

Brandon Williamson (L) is the projected starting pitcher for the Reds, and he has a 1-1 record, 5.28 ERA and 1.37 WHIP.

Cincinnati Reds @ Minnesota Twins Betting Trends: April 17, 2026

• Probable Starting Pitcher: Joe Ryan      Record this season: 2-1      ERA: 3.80
• Home Record: 1-0
• Last 5 against Reds: 0-1

Why the Minnesota Twins will win

• The Twins have won each of their last five night games against National League opponents following a loss.
• The Reds have lost each of their last five night games against AL Central opponents following a loss.
• The Reds have failed to cover the run line in each of their last five night games following a loss.
• The Twins have covered the run line each of their last four games against teams that held a winning record.
• The Twins have led after 5 innings in each of their last five home night games.
• The Twins have won the first inning in each of their last four night games.
• The Reds have trailed after 3 innings in each of their last seven Friday night games as road underdogs.

• Probable Starting Pitcher: Brandon Williamson      Record this season: 1-1      ERA: 5.28
• Road Record: 1-0
• Last 5 against Twins: –

Why the Cincinnati Reds will win

• The Reds have won seven of their last eight games as underdogs against AL Central opponents.
• The Twins have lost 10 of their last 12 games as favorites.
• The Twins have failed to cover the run line in 11 of their last 12 games as favorites.
• The Reds have covered the run line in seven of their last eight games as underdogs against AL Central opponents.
• The Twins have trailed after 5 innings in each of their last six home games against opponents that held a winning record.
• The Twins have lost the first inning in five of their last six home games against opponents that held a winning record.
• The Twins have trailed after 3 innings in three of their last four home games against opponents that held a winning record.

Total Runs Facts

• Each of the Reds’ last six games as underdogs against AL Central opponents have gone OVER the total runs line.
• Eight of the last nine games between the Reds and Twins at Target Field have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Twins’ last six games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Reds’ last four games as underdogs.

Minnesota Twins Player Prop Facts

• Byron Buxton has hit at least one home run in four of his last five appearances against the Reds.
• Joe Ryan has recorded eight strikeouts in three of his last four home appearances against opponents that held a winning record.
• Josh Bell has recorded at least one hit in each of his last 13 appearances with his team as a favorite against NL Central opponents.

Cincinnati Reds Player Prop Facts

• Elly De La Cruz has hit a home run in each of the Reds’ last four road games against AL Central opponents.
• Elly De La Cruz has recorded at least one hit in each of the Reds’ last 13 road games against AL opponents that held a winning record.
• Sal Stewart ranks T3rd in the league in Home Runs (7) this season.

Matchup/League Facts

• The Twins rank 3rd in the league for home runs this season (26).
• The Twins rank 4th in the league for home runs allowed this season (13).
• The Reds rank 30th in the league for doubles this season (17).
• The Reds rank 29th in the league for hits this season (123).

Reds vs Twins Prediction

The Reds are 4-2 in their last 6 meetings against the Twins and are 2-1 in their last 3 visits in Minnesota.

In this Reds vs Twins Prediction, the Twins are coming as -180 home favorites. The Twins have been red-hot lately with an 8-2 record in their last 10 games and also have the pitching advantage today, as Joe Ryan goes up against Brandon Williamson. Minnesota also has a superior offense, as its ranks 4^th in runs per game in baseball, while the Reds are third to last and they are averaging almost 8 runs per game in their last five games. Lay the juice and take the better team to take care of business at home. Take the Twins on the moneyline.