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Royals vs Orioles Prediction 4/22/26 MLB Picks Today

Baltimore Orioles (11-13) vs. Kansas City Royals (8-16)
April 22, 2026 2:10 pm EDT
The Line: Kansas City Royals 0.0001 / Baltimore Orioles 0.0001; Over/Under: 0.0001
(Get latest betting odds)

The Baltimore Orioles and Kansas City Royals meet Wednesday in MLB action at Kauffman Stadium. Here’s a Royals vs. Orioles Prediction. This article will include a Royals vs. Orioles Pick.

Baltimore Orioles Betting Preview

The Baltimore Orioles are 11-13 on the year and play the Red Sox and Astros next. The Baltimore Orioles are batting .227 on the season and have a .318 OBP, and a .372 slugging percentage. The Baltimore Orioles pitching staff has a 3.92 ERA and a 1.36 WHIP. Taylor Ward leads the Baltimore Orioles with 27 hits and 11 RBI while Gunnar Henderson and Jeremiah Jackson have combined for 42 hits and 32 RBI.


Chris Bassitt gets the ball for the Baltimore Orioles, and he is 0-2 with a 6.19 ERA and 7 strikeouts this season. Bassitt is 1-2 with a 3.60 ERA and 33 strikeouts in his career against the Los Angeles Angels.

Kansas City Royals Betting Preview

The Kansas City Royals are 8-16 on the year and play the Athletics and Angels next. The Kansas City Royals are batting .227 on the season, have a .305 OBP, and have a .352 slugging percentage. The Kansas City Royals pitching staff has a 4.58 ERA and a 1.38 WHIP. Bobby Witt Jr. leads the Kansas City Royals with 26 hits and 10 RBI while Maikel Garcia and Jac Caglianone have combined for 44 hits and 12 RBI.

Michael Wacha gets the ball for the Kansas City Royals, and he is 2-0 with a 1.00 ERA and 23 strikeouts this season. Wacha is 3-3 with a 5.22 ERA and 45 strikeouts in his career against the Baltimore Orioles.

Why the Kansas City Royals will win

  • The home team has won seven of the Royals’ last eight games.
  • The Orioles have lost seven of their last eight day games following a road loss.
  • The favorites have covered the run line in four of the Royals’ last five games.
  • The Orioles have failed to cover the run line in each of their last four day games following a loss.
  • The Orioles have trailed after 5 innings in each of their last five day games against AL Central opponents.
  • The Royals have led after 3 innings in four of their last five day games against opponents that held a losing record.

Why the Baltimore Orioles will win

  • The Royals have lost four of their last five games as home favorites against AL East opponents following a win.
  • The Orioles have won each of their last three games as underdogs against the Royals following a loss.
  • The Royals have failed to cover the run line in each of their last six games.
  • The Orioles have covered the run line in seven of their last eight road games against teams that held a losing record.
  • The Royals have trailed after 3 innings in each of their last five day games against AL East opponents.
  • The Royals have trailed after 5 innings in each of their last six day games against AL East opponents.

Total Runs Facts

  • Four of the Orioles’ last five games have gone OVER the total runs line.
  • Four of the last five games between the Orioles and Royals at Kauffman Stadium have gone OVER the total runs line.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Orioles’ last seven day games against American League opponents.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in 10 of the Royals’ last 11 home games against American League opponents.

Kansas City Royals Player Prop Facts

  • Bobby Witt Jr. has hit a home run in four of the Royals’ last five day games against AL East opponents that held a losing record.
  • Michael Wacha has recorded six or more strikeouts in three of his last four appearances.
  • Michael Wacha has recorded a win in each of his last five appearances against opponents that held a losing record.
  • Starling Marte has recorded at least one hit in each of his last eight home appearances.
  • Michael Wacha ranks 2nd amongst qualified players for Earned Run Average (1.00) this season.

Baltimore Orioles Player Prop Facts

  • Chris Bassitt has recorded four or more strikeouts in each of his last eight appearances in day games against AL Central teams that held a losing record.
  • Jordan Westburg has hit a home run in two of his last three appearances.
  • Ryan Mountcastle has recorded at least one hit in each of his last seven appearances with the Orioles as underdogs against the Royals.

Matchup/League Facts

  • The Royals rank 28th in the league for RBIs this season (77).
  • The Royals rank 27th in the league for runs scored this season (82).
  • The Orioles rank T27th in the league for strikeouts against this season (228).
  • The Orioles rank 25th in the league for hits allowed this season (204).

Royals vs Orioles Prediction

The Orioles aren’t a team I’m running to the window to back and Bassitt has been terrible with his 6.19 ERA and 2.13 WHIP through 16 innings. However, the Royals stink to high heaven and while Wacha has been fabulous through 27 frames, this is one of the worst teams in baseball. Bassitt makes it hard to pull the trigger in this spot, but I’ll simply lean on the better team, pinch my nose, and back the Orioles. Yuck.

Randy Chambers's Free Pick: Baltimore Orioles

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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