Royals vs White Sox Prediction 5/6/25 MLB Picks Today

In this article, we will formulate a Royals vs White Sox prediction for this MLB game on Tuesday, May 6, at Kauffman Stadium in Kansas City, Missouri. Let’s take a look at the prediction for this MLB matchup.

Chicago White Sox Betting Preview

The Chicago White Sox (10-25, 3-14 Away) secured their second series win of the season as they beat the Houston Astros in two of three games at home. Prior to that, the White Sox lost five consecutive series. In Game 1 of the current series against the Royals, Chicago lost 3-0, and Shane Smith took the loss after allowing two runs on five hits with five strikeouts and three walks in 5.0 innings.

This season, the White Sox average 3.65 runs per game (24th in the MLB) on a .216/.297/.328 slash line. Regarding pitching, the White Sox’s staff has a 4.16 ERA (17th) and 1.37 WHIP (23rd). Luis Robert Jr. leads the White Sox with a .188 batting average, five home runs, and 15 RBI this season.

The projected starting pitcher for the White Sox is Sean Burke, who is 2-4 in six starts this season, with a 4.91 ERA and 1.36 WHIP in 33.0 innings.

Kansas City Royals Betting Preview

The Kansas City Royals (20-16, 12-5 Home) are playing their best baseball of the year after winning 12 of the previous 14 games. The Royals swept the Rockies and Rays, while they beat the Astros and Orioles during this stretch. Kansas City opened the series against the White Sox with a 3-0 victory. Cole Ragans got the win after allowing no runs on three hits with 11 strikeouts and two walks over 5.0 innings of work.

This year, the Royals average 3.43 runs per game (27th in the MLB) on a .237/.297/.360 triple-slash. When it comes to pitching, the Royals’ staff has a 3.16 ERA (4th) and 1.20 WHIP (7th). Vinnie Pasquantino leads the Royals with a .191 batting average, six home runs, and 22 RBI this season.

Seth Lugo will take the mound for the Royals on Tuesday. The 35-year-old right-hander has a 3-3 record in seven starts this year with a 3.07 ERA and 1.05 WHIP in 44.0 innings.

Why the Royals will cover

• The White Sox have lost each of their last 11 night games against AL Central opponents that held a winning record.
• The Royals have won 16 of their last 17 home games against AL Central opponents that held a losing record.
• The White Sox have failed to cover the run line in each of their last seven night games following a loss.
• The favorites have covered the run line in each of the last six games between the White Sox and Royals at Kauffman Stadium.
• The Royals have led after 5 innings in six of their last seven night games.

Total Runs Facts

• Each of the Royals’ last seven night games against American League opponents have gone UNDER the total runs line.
• Five of the White Sox’s last six night games as underdogs have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the White Sox’s last four games as road underdogs against AL Central opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Royals’ last four games.

Matchup/League Facts

• The Royals rank 4th in the league for ERA this season (3.07).
• The Royals rank 4th in the league for runs allowed this season (119).
• The White Sox rank 28th in the league for batting average this season (.215).
• The White Sox rank T27th in the league for hits this season (243).

Royals vs White Sox Prediction

The Royals have dominated the White Sox lately, as they won nine of the previous ten H2H encounters. Kansas City won each of the last seven games against Chicago, and I am backing the Royals to do it again on Tuesday. Seth Lugo allowed a .130 BA in 46 at-bats against the White Sox in his career. He allowed just two runs in his last two starts, and I’d be surprised if the White Sox score more than two off him in the opening five or six innings. Sean Burke, on the other hand, is a talented pitcher but is rather inconsistent. Following a shutout of the Brewers in his last start, I think the in-form Royals will get to him early on here. Back Kansas City to win and cover the run line.