Arizona Diamondbacks (80-79) vs. San Diego Padres (87-72)
September 26, 2025 9:40 pm EDT
The Line: San Diego Padres -149 / Arizona Diamondbacks +123; Over/Under: 7.5
(Get latest betting odds)
The Arizona Diamondbacks and the San Diego Padres meet Friday in MLB action from Petco Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Padres vs Diamondbacks Prediction.
Starting Pitching Matchup
The Arizona Diamondbacks will send out Zac Gallen for the start here and Gallen is 13-14 with a 4.70 ERA and 172 strikeouts this season. In his last five starts against San Diego, Gallen is 4-0 with a 1.42 ERA and 37 strikeouts. Yu Darvish will get the start for the Padres here and is 4-5 with a 5.51 ERA and 64 strikeouts this season. In his last five starts against Arizona, Darvish is 2-2 with a 4.94 ERA and 26 strikeouts.
Arizona Diamondbacks Recap
The Arizona Diamondbacks come into this game looking to bounce back from their 8-0 loss at the hands of the Los Angeles Dodgers last time out to fall to 80-79 this season
Diamondbacks Looking To Keep Playoff Hopes Alive
Corbin Carroll has 146 hits with 31 home runs, 84 RBIs, 17 triples and 32 doubles this season. Carroll also has a team-high 32 stolen bases and Geraldo Perdomo has 26 stolen bases as well as 19 home runs and 98 RBIs with a team-high 169 hits this season. Ketel Marte’s added 26 home runs and 70 RBIs as well on the year and Lourdes Gurriel has 124 hits with 24 doubles, 19 home runs and 80 RBIs.
Why the Arizona Diamondbacks will win
- The underdogs have won seven of the Diamondbacks’ last eight games at Petco Park.
- The Padres have lost each of their last five Friday games as favorites.
- The underdogs have covered the run line in each of the Diamondbacks’ last eight games at Petco Park.
- The Padres have failed to cover the run line in seven of their last eight Friday games as home favorites.
Arizona Diamondbacks Player Prop Facts
- Ildemaro Vargas has recorded at least one hit in each of his last 10 appearances in night games.
- James McCann has hit a home run in two of his last three appearances at Petco Park against opponents that held a winning record.
San Diego Padres Recap
The San Diego Padres come into this game looking to rebound from a 3-1 loss at the hands of the Milwaukee Brewers last time out to sit at 87-72 this season.
Padres Have Four-Game Win Streak Snapped
Manny Machado has 166 hits including a team-high 33 doubles, 26 home runs, 93 RBIs and 14 stolen bases while Fernando Tatis Jr. has 156 hits with 23 home runs and 66 RBIs along with 32 stolen bases of his own this season. Luis Arraez has added 176 hits with 29 doubles, 4 triples, 8 home runs and 61 RBIs while Jackson Merrill’s added 113 hits with 16 home runs and 63 RBIs as well. Xander Bogaerts also has 29 doubles and 20 stolen bases as well this season. Gavin Sheets also has 28 doubles, 19 home runs and 70 RBIs as well this season.
Why the San Diego Padres will win
- The Padres have won each of their last seven home games against NL West opponents following a home loss.
- The Diamondbacks have lost eight of their last nine Friday games at Petco Park.
- The Diamondbacks have failed to cover the run line in each of their last five games against National League opponents following a home loss.
- The Padres have covered the run line in each of their last four home games against NL West opponents following a home loss.
San Diego Padres Player Prop Facts
- Luis Arraez has recorded at least one hit in each of his last 13 appearances.
- Jackson Merrill has hit a home run in four of the Padres’ last five games as home favorites.
- Manny Machado has recorded a Double in three of the Padres’ last four games against the Diamondbacks.
Total Runs Facts
- Twelve of the Padres’ last 15 night games against NL West opponents have gone UNDER the total runs line.
Padres vs Diamondbacks Prediction
I’m backing Arizona in this one. I get the case to be made for San Diego here, but Arizona’s the only team fighting for anything right now, as the Padres have clinched. In fairness, Zac Gallen’s been the much better starter in a lot of his recent starts. The Diamondbacks’ bullpen is always going to be a concern in late game situations, but I think Arizona does enough to get the win in this one.
