Padres vs Diamondbacks Prediction 9/27/25 MLB Picks Today

The Arizona Diamondbacks and the San Diego Padres meet Saturday in MLB action from Petco Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Padres vs Diamondbacks Prediction.

Starting Pitching Matchup

The Arizona Diamondbacks will send out Eduardo Rodriguez for the start here and Rodriguez is 9-8 with a 4.91 ERA and 137 strikeouts this season. In his career, Rodriguez is 1-1 with a 2.30 ERA and 12 strikeouts against the Padres. Michael King will start this one for San Diego and is 5-3 with a 3.57 ERA and 73 strikeouts this season. In his career, King is 2-0 with a 0.00 ERA and 8 strikeouts against Arizona.

Arizona Diamondbacks Recap

The Arizona Diamondbacks come into this game looking to bounce back from a frustrating offensive showing for much of their series opener against San Diego on Friday.

Diamondbacks Playoff Hopes Fading By The Day

Corbin Carroll has 146 hits with 31 home runs, 84 RBIs, 17 triples and 32 doubles this season. Carroll also has a team-high 32 stolen bases and Geraldo Perdomo has 26 stolen bases as well as 19 home runs and 98 RBIs with a team-high 169 hits this season. Ketel Marte’s added 26 home runs and 70 RBIs as well on the year and Lourdes Gurriel has 124 hits with 24 doubles, 19 home runs and 80 RBIs.

Why the Arizona Diamondbacks will win

• The Padres have lost seven of their last eight games as home favorites against the Diamondbacks following a win.
• The Diamondbacks have won each of their last six Saturday games as underdogs.
• The Padres have failed to cover the run line in each of their last six games as favorites against the Diamondbacks following a win.
• The underdogs have covered the run line in eight of the Diamondbacks’ last nine games at Petco Park.

Arizona Diamondbacks Player Prop Facts

• Eduardo Rodriguez has recorded a win in each of his last four appearances with the Diamondbacks as underdogs.
• James McCann has hit a home run in three of his six previous appearances at Petco Park against opponents that held a winning record.
• Ildemaro Vargas has recorded at least one hit in each of his last 11 appearances in night games.
• Geraldo Perdomo ranks 4th amongst qualified players for On Base Percentage (.391) this season.

San Diego Padres Recap

The San Diego Padres come into this game looking to keep their momentum going after beating up on Arizona for much of Friday’s opening matchup.

Padres Prepping For Postseason Run

Manny Machado has 166 hits including a team-high 33 doubles, 26 home runs, 93 RBIs and 14 stolen bases while Fernando Tatis Jr. has 156 hits with 23 home runs and 66 RBIs along with 32 stolen bases of his own this season. Luis Arraez has added 176 hits with 29 doubles, 4 triples, 8 home runs and 61 RBIs while Jackson Merrill’s added 113 hits with 16 home runs and 63 RBIs as well. Xander Bogaerts also has 29 doubles and 20 stolen bases as well this season. Gavin Sheets also has 28 doubles, 19 home runs and 70 RBIs as well this season.

Why the San Diego Padres will win

• The Padres have won each of their last four night games against National League opponents.
• The Diamondbacks have lost four of their last five road games against teams that held a winning record.
• The Padres have covered the run line in seven of their last eight games as home favorites against NL West opponents.
• The Diamondbacks have failed to cover the run line in each of their last five night games against National League opponents following a loss.

San Diego Padres Player Prop Facts

• Jackson Merrill has hit a home run in three of the Padres’ last four games as home favorites.
• Luis Arraez has recorded at least one hit in each of his last 14 appearances.
• Luis Arraez ranks 3rd in the league in Hits (180) this season.

Total Runs Facts

• Five of the Padres’ last six night games against National League opponents have gone OVER the total runs line.
• Nine of the Diamondbacks’ last 12 games as underdogs against the Padres have gone OVER the total runs line.

Padres vs Diamondbacks Prediction

I’m on San Diego here. I think Arizona’s best shot was getting out of the gates strong on Friday and while they did, San Diego quickly turned the tide and I just think Arizona’s cooked at this point. The Padres are just rolling along going into the postseason, and I think King will prove to be a solid option going forward, and it starts with a strong outing here. Give me San Diego.