San Diego Padres vs Colorado Rockies Prediction 9/14/25 MLB Picks Today

The Colorado Rockies and the San Diego Padres meet Sunday in MLB action from Petco Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Colorado Rockies vs. San Diego Padres prediction.

Starting Pitching Matchup

The Colorado Rockies will start German Marquez here and Marquez is 3-13 with a 6.31 ERA and 77 strikeouts this season. In his last five starts against the Padres, Marquez is 3-1 with a 4.25 ERA and 23 strikeouts. Yu Darvish will get the nod for the Padres here and is 3-5 with a 5.65 ERA and 55 strikeouts this season. In his last five starts against the Rockies, Darvish is 3-1 with a 5.72 ERA and 34 strikeouts.

Colorado Rockies Recap

The Colorado Rockies come into this game looking to rebound from their 11-3 loss at the hands of the Padres in Saturday’s matchup to sit at 41-108 this season. After this series, the Rockies will make the trip back to Coors Field for a set against the Miami Marlins.

Rockies Drop 8 Of Their Last 10, Face Another Series L

Hunter Goodman leads the Rockies with 133 hits including 25 doubles, 4 triples, 29 home runs and 86 RBIs while Michael Toglia has 58 hits with 15 doubles, 11 home runs and 32 RBIs but also has 126 strikeouts. Kyle Farmer has 14 doubles while Jordan Beck has 15 home runs, 25 doubles, 50 RBIs, 5 triples and 16 stolen bases. Brenton Doyle has 110 hits with 20 doubles, 14 home runs, 55 RBIs and 16 stolen bases. Mickey Moniak has 100 hits with 17 doubles, 8 triples and 19 home runs with 57 RBIs. 

Why the Colorado Rockies will win

• The Padres have lost 10 of their last 15 games as favorites against National League opponents following a home win.
• The underdogs have won eight of the Padres’ last 12 games at Petco Park.
• The Padres have failed to cover the run line in each of their last four home games following a win.
• The underdogs have covered the run line in seven of the Padres’ last nine games at Petco Park.

Colorado Rockies Player Prop Facts

• Brenton Doyle has hit a home run in two of the Rockies’ last three day games against NL West opponents that held a winning record.
• German Marquez has recorded a win in five of his last six road appearances against the Padres.
• German Marquez has recorded four or more strikeouts in 28 of his last 32 appearances in day games against teams that held a winning record.
• Thairo Estrada has recorded at least one hit in each of his last nine appearances at Petco Park.

San Diego Padres Recap

The San Diego Padres come into this game looking to add on to their win over Colorado last time out to sit at 81-68 this season. After this series, the Padres will head to New York for a series against the New York Mets.

Padres Looking For Series Win

Manny Machado has 155 hits including a team-high 33 doubles, 23 home runs, 84 RBIs and 13 stolen bases while Fernando Tatis Jr. has 143 hits with 21 home runs and 63 RBIs along with 29 stolen bases of his own this season. Luis Arraez has added 159 hits with 29 doubles, 4 triples, 7 home runs and 54 RBIs while Jackson Merrill’s added 98 hits with 10 home runs and 55 RBIs as well. Xander Bogaerts also has 29 doubles and 20 stolen bases as well this season. Gavin Sheets also has 26 doubles, 19 home runs and 64 RBIs as well this season.

Why the San Diego Padres will win

• The Rockies have lost each of their last 11 day games against NL West opponents following a road loss.
• The Padres have won seven of their last eight home games against the Rockies.
• The Rockies have failed to cover the run line in 10 of their last 11 games after playing the previous day.
• The favorites have covered the run line in seven of the Rockies’ last eight games.

San Diego Padres Player Prop Facts

• Jackson Merrill has hit a home run in three of the Padres’ last four games against the Rockies.
• Manny Machado has recorded a Double in each of the Padres’ last five day games against NL opponents that held a losing record.
• Yu Darvish has recorded seven or more strikeouts in each of his last six Sunday appearances at Petco Park.
• Yu Darvish has recorded a win in each of his last three appearances against the Rockies.
• Xander Bogaerts has recorded at least one hit in each of his last seven appearances in day games against NL teams that held a losing record.
• Luis Arraez ranks 3rd in the league in Hits (165) this season.

Total Runs Facts

• Six of the Padres’ last seven games have gone UNDER the total runs line.
• Four of the Rockies’ last five day games after playing the previous day have gone UNDER the total runs line.

Colorado Rockies vs. San Diego Padres Prediction

I’m going to back the over in this one. I lean towards the Padres, but I think it’s still going to be a high-scoring game regardless of who gets the win here. Marquez has been more than hittable as of late with 17 runs allowed and 5 homers in his last three starts since returning from injury across 14.1 innings and I think the Padres keep it going in this one. The Rockies can drum up some offense off of Darvish as well, and I think we get a high-scoring battle here. Give me the over.