San Diego Padres vs Minnesota Twins Prediction 8/22/26 MLB Picks Today

The Minnesota Twins and the San Diego Padres meet Saturday in MLB action from Petco Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Minnesota Twins vs. San Diego Padres prediction.

Starting Pitching Matchup

The Minnesota Twins will send out Dean Kremer here and Kremer is 2-4 with a 5.40 ERA and 53 strikeouts this season. Casey Mize will start for Detroit and is 5-7 with a 3.18 ERA and 95 strikeouts this season.

Minnesota Twins Recap

The Minnesota Twins come into this game looking to bounce back from a 6-2 loss at the hands of the Padres on Friday to sit at 63-66 this season. After this series, the Twins will head on the road for a series against the Athletics.

Twins Have Three-Game Win Streak Snapped

Entering Friday, Byron Buxton has 90 hits with 17 doubles, a triple, 25 home runs and 46 RBIs while Josh Bell’s added 117 hits with 26 doubles, 17 home runs and 77 RBIs. Luke Keaschall has 109 hits with 19 doubles, 7 homers and 36 RBIs. Brooks Lee has 110 hits with 19 doubles, 3 triples, 18 home runs and 67 RBIs and Victor Caratini has 38 RBIs while Kody Clemens has 97 hits with 21 doubles, 5 triples, 21 home runs and 61 RBIs this season.

San Diego Padres Recap

The San Diego Padres come into this game looking to add on to their win over the Twins from Friday to improve to 69-60 this season. After this series, the Padres will take on the Pittsburgh Pirates in a matchup at home.

Padres Alternate Wins & Losses In 7 Straight

Going into Friday, Jackson Merrill has 116 hits with 20 doubles, 19 home runs and 63 RBIs while Gavin Sheets has 74 hits with 15 doubles, 16 home runs and 46 RBIs as well on the year. Fernando Tatis Jr. has 137 hits with 26 doubles, 15 home runs and 61 RBIs and Xander Bogaerts has 91 hits with 12 doubles, 11 home runs and 46 RBIs. Manny Machado also has 100 hits with 20 doubles, 24 home runs and 71 RBIs as well on the year.

Minnesota Twins @ San Diego Padres Betting Trends: August 22, 2026

• Probable Starting Pitcher: Casey Mize      Record this season: 5-7      ERA: 3.18
• Home Record: 2-3
• Last 5 against Twins: 3-2

Why the San Diego Padres will win

• The Padres have won each of their last seven home games against AL Central opponents following a home win.
• The Twins have lost seven of their last eight road games against National League opponents following a loss.
• The Padres have covered the run line in each of their last five home games.
• The Twins have failed to cover the run line in each of their last four games against NL West opponents.
• The Padres have led after 5 innings in each of their last four home games against opponents that held a losing record.
• The Twins have lost the first inning in each of their last seven road games against National League opponents.
• The Padres have led after 3 innings in each of their last four home games against American League opponents that held a losing record.

• Probable Starting Pitcher: Dean Kremer      Record this season: 2-4      ERA: 5.40
• Road Record: 0-3
• Last 5 against Padres: 0-2

Why the Minnesota Twins will win

• The Twins have won each of their last four games as underdogs against NL West opponents following a road loss.
• The Padres have lost three of their last four games as favorites following a win.
• The Twins have covered the run line in each of their last 10 road games after playing the previous day.
• The Padres have failed to cover the run line in eight of their last nine games against AL Central opponents following a win.
• The Twins have led after 5 innings in each of their last six Saturday games against NL West opponents that held a winning record.
• The Padres have trailed after 3 innings in five of their last six night games against American League opponents.

Total Runs Facts

• Each of the Padres’ last six games after playing the previous day have gone UNDER the total runs line.
• Each of the Twins’ last four night games after playing the previous day have gone UNDER the total runs line.
• There has been at least one run scored in the first inning in each of the Twins’ last seven road games against National League opponents.
• There has been no run scored during the first inning in seven of the Padres’ last eight games as home favorites against AL Central opponents.

San Diego Padres Player Prop Facts

• Ty France has hit a home run in each of his last two appearances against the Twins.
• Casey Mize has recorded a win in three of his last four appearances against the Twins.
• Casey Mize has recorded five or more strikeouts in five of his last six appearances in night games.
• Manny Machado has recorded at least one hit in each of the Padres’ last seven home games against AL opponents.
• Fernando Tatis Jr. ranks 9th in the league in Hits (140) this season.

Minnesota Twins Player Prop Facts

• Byron Buxton has hit a home run in two of the Twins’ last three games against the Padres.
• Dean Kremer has recorded five or more strikeouts in six of his last seven road appearances against opponents that held a winning record.
• Luke Keaschall has recorded at least one hit in each of his last 14 appearances in night games.

Matchup/League Facts

• The Padres rank T5th in the league for steals this season (124).
• The Padres rank T25th in the league for hits this season (1010).
• The Twins are one of only four teams in the league to rank top 10 in both strikeouts and on-base percentage this season.
• The Twins rank 26th in the league for ERA this season (4.63).

Minnesota Twins vs. San Diego Padres Prediction

I’m on the Padres in this one. I just think this is a great spot for the Padres with Dean Kremer going for Minnesota in this game. Kremer has been a more than hittable option in the majors the last couple of seasons, and the Padres are doing a great job against right-handed pitching this season. Give me San Diego.