San Diego Padres vs San Francisco Giants Prediction 3/31/26 MLB Picks Today

The San Francisco Giants and the San Diego Padres meet Tuesday in MLB action from Petco Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a San Francisco Giants vs. San Diego Padres prediction.

Starting Pitching Matchup

The San Francisco Giants will send out Logan Webb for the start here and Webb is 0-1 with a 10.80 ERA and 7 strikeouts this season. In his last five starts against the Padres, Webb is 1-3 with a 4.60 ERA and 23 strikeouts. The San Diego Padres will send out German Marquez here and Marquez was 3-16 with a 6.70 ERA and 83 strikeouts last season. In his last five starts against the Giants, Marquez is 0-4 with a 7.30 ERA and 18 strikeouts. 

San Francisco Giants Recap

The San Francisco Giants come into this game looking to add on to their 3-2 win over the Padres from Monday’s opener to improve to 1-3 this season. After this series, the Giants will head home for a series against the New York Mets.

Giants Nab First W Of Season

Going into Monday’s opener, Rafael Devers, Luis Arraez and Heliot Ramos each have 3 hits with Devers and Ramos each logging a double while Matt Chapman has an RBI and Jung Hoo Lee has a double. Willy Adames and Harrison Bader each have a base knock as well this season.

Why the San Francisco Giants will win

• The Giants have won eight of their last nine games against NL West opponents that held a losing record.
• The Padres have lost four of their last five games.
• The Giants have covered the run line in eight of their last nine road games against teams that held a losing record.
• The Padres have failed to cover the run line in four of their last five games.

San Francisco Giants Player Prop Facts

• Heliot Ramos has hit a home run in three of the Giants’ last five games as favorites.
• Logan Webb has recorded a win in four of his last five appearances against opponents that held a losing record.
• Logan Webb has recorded six or more strikeouts in 12 of his last 13 appearances against opponents that held a losing record.
• Matt Chapman has recorded at least one hit in each of his last 12 appearances in night games against teams that held a losing record.

San Diego Padres Recap

The San Diego Padres come into this game looking to bounce back from their loss at the hands of the Giants on Monday to sit at 1-3 this season. After this series, the San Diego Padres will head on the road for a series against the Boston Red Sox.

Padres Looking To Even Up Series

Entering Monday’s series opener, Xander Bogaerts has 3 hits with a double and an RBI while Ramon Laureano has 5 hits with a double, a home run and two RBIs. Jackson Merrill and Manny Machado each have a pair of hits with a double and Jake Cronenworth has 3 hits as well this season. Fernando Tatis Jr. also has a pair of base hits and an RBI as well this season.

Why the San Diego Padres will win

• The Giants have lost each of their last seven games as road favorites against the Padres following a win.
• The Padres have won each of their last six games as home underdogs against National League opponents following a loss.
• The Padres have covered the run line in each of their last 15 games as underdogs against the Giants.
• The Giants have failed to cover the run line in each of their last seven games as favorites against the Padres following a win.

San Diego Padres Player Prop Facts

• Jackson Merrill has hit a home run in three of the Padres’ last four home games against opponents that held a losing record.
• German Marquez has recorded four or more strikeouts in 26 of his last 29 home appearances against NL opponents that held a losing record.
• Nick Castellanos has recorded at least one hit in 17 of his last 18 appearances with his team as a home underdog against NL opponents.

Total Runs Facts

• Nine of the Giants’ last 10 games as favorites against the Padres have gone UNDER the total runs line.
• Seven of the Padres’ last eight games after playing the previous day have gone UNDER the total runs line.

San Francisco Giants vs. San Diego Padres Prediction

I’m on the over here. I was on the under on Monday but I think the over is the way to go here. I didn’t love how Logan Webb looked against the Yankees in his opening start, and that was at home where Webb’s been far more effective his entire career, and now faces a Padres team that’s had his number over the years. On the other side, I don’t know how German Marquez nabbed another starting job at the MLB level, but I think that this is headed for a higher-scoring game so give me the over here.