San Diego Padres vs San Francisco Giants Prediction 8/19/25 MLB Picks Today

The San Francisco Giants and the San Diego Padres meet Tuesday in MLB action from Petco Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a San Francisco Giants vs. San Diego Padres prediction.

Starting Pitching Matchup

The San Francisco Giants will send out Kai-Wei Teng for the start here and Teng is 1-2 with a 9.90 ERA and 8 strikeouts this season. This will be Teng’s second career start against the Padres. The San Diego Padres will start Nick Pivetta here and Pivetta is 12-4 with a 2.87 ERA and 144 strikeouts this season. In his last five starts against the Giants, Pivetta is 3-1 with a 4.00 ERA and 29 strikeouts.

San Francisco Giants Recap

The San Francisco Giants come into this game looking to build on their 4-3 win over the Padres from Monday’s series opener to sit at 61-64 this season. After this series, the Giants will head on the road again for a series against the Milwaukee Brewers.

Giants Win Back-To-Back Games

Jung Hoo Lee has 116 hits including a team-high 28 doubles along with 10 triples, 6 home runs and 46 RBIs with 10 stolen bases while Heliot Ramos has 128 hits with 21 doubles, 15 home runs and 53 RBIs. Wilmer Flores also 13 home runs and 63 RBIs while Tyler Fitzgerald has a team-high 9 stolen bases as well on the year. Matt Chapman also has 79 hits with 16 home runs and 44 RBIs along with 15 doubles and Willy Adames has 103 hits with 18 doubles, 19 home runs and 62 RBIs of his own this season.

Why the San Francisco Giants will win

• The Giants have won five of their last six games as road underdogs.
• The Padres have lost three of their last four games as home favorites against NL West opponents.
• The Padres have failed to cover the run line in eight of their last nine home games against National League opponents that held a losing record.
• The road team has covered the run line in seven of the last eight games between the Giants and Padres.

San Francisco Giants Player Prop Facts

• Jung Hoo Lee has recorded a Double in four of the Giants’ last five road games against opponents that held a winning record.
• Rafael Devers has hit a home run in each of the Giants’ last two games as road underdogs.
• Rafael Devers has recorded at least one hit in each of his last 15 appearances with his team as a road underdog.
• Rafael Devers ranks 9th amongst qualified players for On Base Percentage (.377) this season.

San Diego Padres Recap

The San Diego Padres come into this game looking to rebound from their loss at the hands of the Giants in Monday’s opener to slip to 69-56 this season. After this series, the Padres will head home for a series rematch against the Los Angeles Dodgers.

Padres Lose 4 Straight

Manny Machado has 140 hits including a team-high 30 doubles, 20 home runs, 72 RBIs and 11 stolen bases while Fernando Tatis Jr. has 123 hits with 17 home runs and 50 RBIs along with 24 stolen bases of his own this season. Luis Arraez has added 141 hits with 26 doubles, 4 triples, 6 home runs and 46 RBIs while Jackson Merrill’s added 91 hits with 9 home runs and 51 RBIs as well. Xander Bogaerts also has 28 doubles and 19 stolen bases as well this season. Gavin Sheets also has 17 doubles, 15 home runs and 54 RBIs as well this season.

Why the San Diego Padres will win

• The Padres have won each of their last 10 home games following a home loss.
• The Giants have lost six of their last seven night games against the Padres following a win.
• The Padres have covered the run line in each of their last five night games against the Giants at Petco Park following a home loss.
• The Giants have failed to cover the run line in six of their last seven night games against the Padres following a win.

San Diego Padres Player Prop Facts

• Xander Bogaerts has hit a home run in three of the Padres’ last seven games as favorites.
• Xander Bogaerts has recorded a Double in each of the Padres’ last four games against opponents that held a losing record.
• Nick Pivetta has recorded seven or more strikeouts in each of his last five appearances in night games against NL teams that held a losing record.
• Xander Bogaerts has recorded at least one hit in each of the Padres’ last nine games as home favorites against NL opponents.
• Nick Pivetta has recorded a win in five of his last six appearances with the Padres as home favorites against NL opponents.
• Luis Arraez ranks 3rd in the league in Hits (141) this season.

Total Runs Facts

• Each of the Padres’ last six night games against NL West opponents have gone UNDER the total runs line.
• Each of the Giants’ last four night games after playing the previous day have gone UNDER the total runs line.

San Francisco Giants vs. San Diego Padres Prediction

I’m looking at the Padres here. I personally think the Padres kind of got shafted in game one, because of a bogus overturned home run that proved to be costly, but it shouldn’t be as close in game two with Teng starting as Teng’s been batting practice for much of the season in my opinion. Pivetta’s been rock solid at home and I think he gets the job done in this game. Give me the Padres.