San Francisco Giants vs Arizona Diamondbacks Prediction 9/10/25 MLB Picks Today

The Arizona Diamondbacks and the San Francisco Giants meet Wednesday in MLB action from Oracle Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Arizona Diamondbacks vs. San Francisco Giants prediction.

Starting Pitching Matchup

The Arizona Diamondbacks will send out Eduardo Rodriguez for the start here and Rodriguez is 7-8 with a 5.22 ERA and 124 strikeouts this season. In his career, Rodriguez is 1-1 with a 6.14 ERA and 22 strikeouts against the Giants. Carson Seymour will get the start for the Giants here and is 1-2 with a 4.25 ERA and 20 strikeouts this season. This will be Seymour’s first career start against the Diamondbacks.

Arizona Diamondbacks Recap

The Arizona Diamondbacks come into this game looking to rebound from a 5-3 loss at the hands of the Giants on Tuesday to sit at 72-74 on the year. After this series, the Diamondbacks will head on the road for a series against the Minnesota Twins.

Diamondbacks Lose Three In A Row

Corbin Carroll has 131 hits with 30 home runs, 74 RBIs, 16 triples and 29 doubles this season. Carroll also has a team-high 26 stolen bases and Geraldo Perdomo has 24 stolen bases as well as 17 home runs and 91 RBIs with a team-high 151 hits this season. Ketel Marte’s added 25 home runs and 64 RBIs as well on the year and Lourdes Gurriel has 124 hits with 24 doubles, 19 home runs and 80 RBIs.

Why the Arizona Diamondbacks will win

• The Diamondbacks have won 12 of their last 13 day games against NL West opponents following a loss.
• The Giants have lost nine of their last 13 games as home favorites against National League opponents.
• The Giants have failed to cover the run line in 19 of their last 22 games as home favorites against National League opponents.
• The Diamondbacks have covered the run line in 12 of their last 14 games as underdogs against the Giants following a road loss.

Arizona Diamondbacks Player Prop Facts

• Gabriel Moreno has hit a home run in four of his last seven appearances with the Diamondbacks as underdogs against NL West opponents.
• Eduardo Rodriguez has recorded a win in three of his last four road appearances.
• Eduardo Rodriguez has recorded five or more strikeouts in 20 of his last 25 appearances in day games.
• James McCann has recorded a Double in three of his last four appearances in day games against NL West teams that held a winning record.
• Lourdes Gurriel Jr. has recorded at least one hit in each of his last 12 road appearances against the Giants.
• Ketel Marte ranks 6th amongst qualified players for On Base Percentage (.384) this season.

San Francisco Giants Recap

The San Francisco Giants come into this game looking to add on to their win over the Diamondbacks from Tuesday’s matchup to improve to 74-71 this season. After this series, the Giants will head home for a series against the Los Angeles Dodgers.

Giants Win 7 Of Last 9 Games

Jung Hoo Lee has 139 hits including a team-high 30 doubles along with 11 triples, 8 home runs and 51 RBIs with 10 stolen bases while Heliot Ramos has 146 hits with 23 doubles, 17 home runs and 61 RBIs. Wilmer Flores also 15 home runs and 67 RBIs while Tyler Fitzgerald has 9 stolen bases as well on the year. Matt Chapman also has 96 hits with 21 home runs and 56 RBIs along with 19 doubles and Willy Adames has 122 hits with 19 doubles, 28 home runs and 81 RBIs of his own this season. 

Why the San Francisco Giants will win

• The Giants have won each of their last 10 games as home favorites against NL West opponents following a home win.
• The Diamondbacks have lost each of their last six day games against National League opponents following a loss.
• The Giants have covered the run line in eight of their last nine games.
• The Diamondbacks have failed to cover the run line in seven of their last eight games at Oracle Park against teams that held a winning record.

San Francisco Giants Player Prop Facts

• Jung Hoo Lee has hit a home run in three of the Giants’ last four home games against the Diamondbacks.
• Willy Adames has recorded at least one Double in five of his last six home appearances against the Diamondbacks.
• Jung Hoo Lee has recorded at least one hit in each of his last 12 appearances against NL West opponents.
• Rafael Devers ranks 9th amongst qualified players for On Base Percentage (.378) this season.

Total Runs Facts

• Seven of the last eight games between the Diamondbacks and Giants have gone OVER the total runs line.
• Four of the Diamondbacks’ last five games have gone OVER the total runs line.

Arizona Diamondbacks vs. San Francisco Giants Prediction

I’m on the Giants in this one. I just can’t trust Eduardo Rodriguez in a starter’s capacity right now, and I think that the Giants can get to him here. Is Seymour a reliable option for the Giants? Not necessarily, but the Giants have the far more trustworthy bullpen when it gets to the later stages of this game and I think they get the job done here. Give me San Francisco here.