San Francisco Giants vs Baltimore Orioles Prediction 8/31/25 MLB Picks Today

The Baltimore Orioles and the San Francisco Giants meet Sunday in MLB action from Oracle Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Baltimore Orioles vs. San Francisco Giants prediction.

Starting Pitching Matchup

The Baltimore Orioles will send out Tomoyuki Sugano here and Sugano is 10-6 with a 4.06 ERA and 91 strikeouts this season. This will be Sugano’s first career start against the Giants. The San Francisco Giants will be sending Justin Verlander to the mound in this one and Verlander is 2-10 with a 4.47 ERA and 104 strikeouts this season. In his last five starts against the Orioles, Verlander is 0-1 with a 3.12 ERA and 36 strikeouts.

Baltimore Orioles Recap

The Baltimore Orioles come into this game looking to add on to their 11-1 win over the Giants from Saturday’s matchup to sit at 61-75 this season. After this series, the Orioles will head on the road for a series against the San Diego Padres.

Orioles Snap Five-Game Losing Skid

Adley Rutschman has 70 hits with 16 doubles, 9 homers and 29 RBIs. Jackson Holliday has 120 hits with 18 doubles, 2 triples, 15 homers and 49 RBIs. Gunnar Henderson has 132 hits with 30 doubles, 5 triples, 16 home runs and 59 RBIs with 20 stolen bases and 119 strikeouts while Holliday has a team-high 120 strikeouts as well this season. 

Why the Baltimore Orioles will win

• The Giants have lost eight of their last nine games as home favorites following a home loss.
• The Orioles have won three of their last four games as road underdogs.
• The Giants have failed to cover the run line in 17 of their last 18 games as home favorites following a loss.
• The Orioles have covered the run line in seven of their last eight road games.

Baltimore Orioles Player Prop Facts

• Ryan Mountcastle has recorded at least one Double in each of his last four appearances against NL opponents.
• Tyler O’Neill has hit at least one home run in four of his last five appearances against NL West opponents that held a losing record.
• Adley Rutschman has recorded at least one hit in each of his last eight road appearances against NL opponents.

San Francisco Giants Recap

The San Francisco Giants come into this game looking to rebound from their loss at the hands of the O’s on Saturday to fall to 67-69 this year. After this series, the Giants will head on the road for a set against the Colorado Rockies.

Giants Have Six-Game Win Streak Snapped

Jung Hoo Lee has 125 hits including a team-high 30 doubles along with 10 triples, 7 home runs and 48 RBIs with 10 stolen bases while Heliot Ramos has 135 hits with 23 doubles, 16 home runs and 57 RBIs. Wilmer Flores also 14 home runs and 64 RBIs while Tyler Fitzgerald has 9 stolen bases as well on the year. Matt Chapman also has 84 hits with 18 home runs and 48 RBIs along with 16 doubles and Willy Adames has 110 hits with 18 doubles, 24 home runs and 69 RBIs of his own this season. 

Why the San Francisco Giants will win

• The Orioles have lost each of their last five games against NL West opponents following a road win.
• The Giants have won each of their last five day games against American League opponents following a home loss.
• The Orioles have failed to cover the run line in seven of their last eight games against NL West opponents following a win.
• The favorites have covered the run line in each of the Orioles’ last four games at Oracle Park.

San Francisco Giants Player Prop Facts

• Willy Adames has hit at least one home run in three of his last four appearances in day games against AL East teams that held a losing record.
• Justin Verlander has recorded seven or more strikeouts in each of his last six appearances in day games against AL East teams that held a losing record.
• Dominic Smith has recorded at least one hit in each of his last 13 appearances with the Giants as favorites.
• Rafael Devers ranks 10th amongst qualified players for On Base Percentage (.379) this season.

Total Runs Facts

• Each of the last six games between the Orioles and Giants have gone OVER the total runs line.
• Five of the Orioles’ last six road games after playing the previous day have gone OVER the total runs line.

Baltimore Orioles vs. San Francisco Giants Prediction

I’m leaning towards the Giants here. I don’t love the form of Justin Verlander, and the fact that the Giants haven’t really won any games as a team with Verlander as the starter. However, the Giants have still been smacking right-handed pitching as of late and were playing some solid baseball before Saturday’s loss. I’ll take a shot on the Giants to finish the series with a win here.