Giants vs Rockies Prediction 9/26/25 MLB Picks Today

The Colorado Rockies and the San Francisco Giants meet Friday in MLB action from Oracle Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Giants vs Rockies Prediction.

Starting Pitching Matchup

The Colorado Rockies will send out German Marquez for the start here and Marquez is 3-15 with a 6.49 ERA and 82 strikeouts this season. In his last five starts against the Giants, Marquez is 1-3 with a 5.81 ERA and 24 strikeouts. Trevor McDonald will get the nod for the Giants here and is 0-0 with 3.38 ERA and 4 strikeouts this season. This will be McDonald’s first career start against the Colorado Rockies.

Colorado Rockies Recap

The Colorado Rockies come into this game looking to bounce back from their 6-2 loss at the hands of the Seattle Mariners last time out to sit at 43-116 this season. 

Rockies Looking To Finish Season On Positive Note

Hunter Goodman leads the Rockies with 147 hits including 27 doubles, 5 triples, 30 home runs and 90 RBIs while Michael Toglia has 58 hits with 15 doubles, 11 home runs and 32 RBIs but also has 132 strikeouts. Kyle Farmer has 14 doubles while Jordan Beck has 15 home runs, 27 doubles, 52 RBIs, 5 triples and 19 stolen bases. Brenton Doyle has 113 hits with 21 doubles, 14 home runs, 56 RBIs and 17 stolen bases. Mickey Moniak has 117 hits with 20 doubles, 8 triples and 24 home runs with 68 RBIs. Tyler Freeman also has 106 hits with 20 doubles and 18 stolen bases so far this season.

Why the Colorado Rockies will win

• The Giants have lost each of their last four games as favorites.
• The underdogs have won each of the Giants’ last four games.
• The Giants have failed to cover the run line in eight of their last nine games as home favorites against National League opponents following a home win.
• The underdogs have covered the run line in each of the Giants’ last four games.

Colorado Rockies Player Prop Facts

• Brenton Doyle has hit a home run in three of his last four road appearances against opponents that held a losing record.
• German Marquez has recorded four or more strikeouts in 15 of his last 17 appearances in night games against NL West teams that held a losing record.
• Ezequiel Tovar has recorded at least one hit in each of his last nine appearances against the Giants.

San Francisco Giants Recap

The San Francisco Giants come into this game looking to add on to their 4-3 win over the St. Louis Cardinals last time out to improve to 78-81 this season.

Giants Trying To Finish Season At .500

Jung Hoo Lee has 143 hits including a team-high 31 doubles along with 11 triples, 8 home runs and 53 RBIs with 10 stolen bases while Heliot Ramos has 157 hits with 24 doubles, 20 home runs and 66 RBIs. Wilmer Flores also has 16 home runs and 71 RBIs while Tyler Fitzgerald has 9 stolen bases as well on the year. Matt Chapman also has 103 hits with 21 home runs and 61 RBIs along with 22 doubles and Willy Adames has 131 hits with 22 doubles, 28 home runs and 84 RBIs of his own this season. 

Why the San Francisco Giants will win

• The Rockies have lost each of their last 13 games at Oracle Park against teams that held a losing record.
• The Giants have won each of their last 11 home games against the Rockies following a win.
• The Giants have covered the run line each of their last nine Friday games against National League opponents that held a losing record.
• The Rockies have failed to cover the run line in 13 of their last 14 games against National League opponents after playing the previous day.

San Francisco Giants Player Prop Facts

• Jung Hoo Lee has recorded at least one hit in each of his last 12 appearances in night games against teams that held a losing record.
• Willy Adames has hit a home run in three of his four previous home appearances against the Rockies after not playing the previous day.
• Matt Chapman has recorded a Double in three of his last four appearances in night games against teams that held a losing record.

Total Runs Facts

• Seven of the Giants’ last eight games as home favorites have gone OVER the total runs line.
• Each of the Rockies’ last five games against National League opponents have gone OVER the total runs line.

Giants vs Rockies Prediction

I’m on the Rockies here. I’m just not in a position where I feel like laying any sort of odds with a San Francisco Giants team that is just playing out the string here. Marquez has been better away from Coors Field for the better part of his career, and I just feel like the value is on Colorado in this matchup. Give me the Rockies here.