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Giants vs Rockies Prediction 9/28/25 MLB Picks Today

Colorado Rockies (43-118) vs. San Francisco Giants (80-81)
September 28, 2025 3:05 pm EDT
The Line: San Francisco Giants -301 / Colorado Rockies +237; Over/Under: 7.5
(Get latest betting odds)

The Colorado Rockies and the San Francisco Giants meet Sunday in MLB action from Oracle Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Giants vs Rockies Prediction.

Starting Pitching Matchup

The Colorado Rockies will start McCade Brown here and Brown is 0-4 with a 7.54 ERA and 21 strikeouts this season. This will be Brown’s first career start against the Giants. Logan Webb will start this one for the Giants and is 14-11 with a 3.30 ERA and 216 strikeouts this season. In his last 5 starts against the Rockies, Webb is 3-1 with a 2.25 ERA and 27 strikeouts.


Colorado Rockies Recap

The Colorado Rockies come into this game looking to bounce back from a 4-3 loss at the hands of the Rockies on Saturday to drop to 43-118 this season.

Rockies Trying To Salvage Win To End Miserable Season

Hunter Goodman leads the Rockies with 147 hits including 27 doubles, 5 triples, 30 home runs and 90 RBIs while Michael Toglia has 58 hits with 15 doubles, 11 home runs and 32 RBIs but also has 132 strikeouts. Kyle Farmer has 14 doubles while Jordan Beck has 15 home runs, 27 doubles, 52 RBIs, 5 triples and 19 stolen bases. Brenton Doyle has 113 hits with 21 doubles, 14 home runs, 56 RBIs and 17 stolen bases. Mickey Moniak has 117 hits with 20 doubles, 8 triples and 24 home runs with 68 RBIs. Tyler Freeman also has 106 hits with 20 doubles and 18 stolen bases so far this season.

Why the Colorado Rockies will win

  • The Giants have lost four of their last five games as favorites after playing the previous day.
  • The underdogs have won six of the Giants’ last nine games at Oracle Park.
  • The Giants have failed to cover the run line in each of their last five games as favorites after playing the previous day.
  • The underdogs have covered the run line in five of the Giants’ last six games.

Colorado Rockies Player Prop Facts

  • Brenton Doyle has hit a home run in three of the Rockies’ last four road games against NL West opponents that held a losing record.
  • Ezequiel Tovar has recorded at least one hit in each of his last 11 appearances against the Giants.

San Francisco Giants Recap

The San Francisco Giants come into this game looking to add on to their win over Colorado from Saturday to improve to 80-81 this season. 

Giants Trying To Finish At .500

Jung Hoo Lee has 143 hits including a team-high 31 doubles along with 11 triples, 8 home runs and 53 RBIs with 10 stolen bases while Heliot Ramos has 157 hits with 24 doubles, 20 home runs and 66 RBIs. Wilmer Flores also has 16 home runs and 71 RBIs while Tyler Fitzgerald has 9 stolen bases as well on the year. Matt Chapman also has 103 hits with 21 home runs and 61 RBIs along with 22 doubles and Willy Adames has 131 hits with 22 doubles, 28 home runs and 84 RBIs of his own this season. 

Why the San Francisco Giants will win

  • The Rockies have lost each of their last 15 games at Oracle Park against teams that held a losing record.
  • The Giants have won each of their last 13 home games against the Rockies following a win.
  • The Rockies have failed to cover the run line in 14 of their last 16 games against National League opponents after playing the previous day.
  • The Giants have covered the run line in 12 of their last 15 home games against the Rockies.

San Francisco Giants Player Prop Facts

  • Heliot Ramos has hit a home run in three of the Giants’ last four games as favorites.
  • Rafael Devers has recorded a Double in each of the Giants’ last three games against NL West opponents that held a losing record.
  • Logan Webb has recorded seven or more strikeouts in five of his last six appearances in day games.
  • Logan Webb has recorded a win in each of his last four home appearances against the Rockies.
  • Wilmer Flores has recorded at least one hit in each of his last 10 appearances against the Rockies.
  • Logan Webb ranks T3rd in the league for total Strikeouts (216) this season.

Total Runs Facts

  • Eight of the Giants’ last nine day games against National League opponents have gone UNDER the total runs line.
  • Six of the Rockies’ last seven games against National League opponents have gone OVER the total runs line.

Giants vs Rockies Prediction

I’m on the Giants here. I tried giving the Rockies the benefit of the doubt in the first two games of this series, and that didn’t end well. Now the Giants get their ace on the mound in a matchup he’s excelled in almost his entire career. I just think Colorado’s ready for this to be over. Give me the Giants.

Chris Ruffolo's Free Pick: San Francisco Giants -301

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Chris Ruffolo

Chris joined the Sports Chat Place team in August 2016 and has a proven system that combines multiple analytical and situational statistics and trends to give out thousands of winning picks over the last three years with winning records across all of the top leagues, Follow Chris Ruffolo on Twitter @ruffthepickdawg

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