San Francisco Giants vs LA Dodgers Prediction 4/22/26 MLB Picks Today

The Los Angeles Dodgers and the San Francisco Giants meet Wednesday in MLB action from Oracle Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Los Angeles Dodgers vs. San Francisco Giants prediction.

Starting Pitching Matchup

The Los Angeles Dodgers will send out Shohei Ohtani for the start here and Ohtani is 2-0 with a 0.50 ERA and 18 strikeouts this season. The San Francisco Giants will start Tyler Mahle for the start here and Mahle is 0-3 with a 7.23 ERA and 21 strikeouts this season.

Los Angeles Dodgers Recap

The Los Angeles Dodgers come into this game looking to bounce back from a 3-1 loss at the hands of the Giants to sit at 16-7 this season. After this series, the Dodgers will head home for a series against the Chicago Cubs.

Dodgers Looking To Rebound

Going into Tuesday, Andy Pages has 30 hits with 4 doubles, 5 home runs and 21 RBIs while Teoscar Hernandez has 19 hits with 3 doubles, 4 home runs and 13 RBIs. Shohei Ohtani has 22 hits with 4 doubles, 5 home runs and 11 RBIs and Freddie Freeman has 24 hits with 7 doubles, a triple, 3 home runs and 14 RBIs this season. Will Smith and Mookie Betts each have a pair of home runs as well this season. Max Muncy’s added 23 hits with 8 home runs and Kyle Tucker has 21 hits with 2 doubles, 3 home runs and 13 RBIs this season.

San Francisco Giants Recap

The San Francisco Giants come into this game looking to add on to their win over the Dodgers from Tuesday’s matchup to sit at 10-13 this season. After this series, the Giants will take on the Miami Marlins in a series at home.

Giants Win 4 Of Last 5

Luis Arraez has 25 hits with a double, 2 triples and 6 RBIs while Willy Adames has 22 hits with 10 doubles, 3 home runs and 6 RBIs. Matt Chapman has 26 hits with 4 doubles, a triple, a home run and 11 RBIs and Harrison Bader has a home run and 3 RBIs while Jung Hoo Lee has 19 hits with 6 doubles and 8 RBIs. Heliot Ramos has 20 hits with 4 doubles, a home run and 11 RBIs this season. Rafael Devers also has 20 hits with 2 doubles, 2 home runs and 8 RBIs but also has a team-high 28 strikeouts this season.

Los Angeles Dodgers @ San Francisco Giants Betting Trends: April 22, 2026

• Probable Starting Pitcher: Tyler Mahle      Record this season: 0-3      ERA: 7.23
• Home Record: 0-2
• Last 5 against Dodgers: 1-2

Why the San Francisco Giants will win

• The underdogs have won five of the Giants’ last six games at Oracle Park.
• The Dodgers have lost four of their last five games as road favorites after playing the previous day.
• The Giants have covered the run line in each of their last five games as underdogs against National League opponents.
• The Dodgers have failed to cover the run line in each of their last seven Wednesday road games.
• The Giants have won the first inning in six of their last seven night games against NL West opponents that held a winning record.
• The Giants have led after 3 innings in each of their last six night games against NL West opponents.
• The Giants have led after 5 innings in each of their last four home games against NL West opponents.

• Probable Starting Pitcher: Shohei Ohtani      Record this season: 2-0      ERA: 0.50
• Road Record: 0-0
• Last 5 against Giants: 1-0

Why the Los Angeles Dodgers will win

• The Giants have lost each of their last 10 games against the Dodgers following a win.
• The Dodgers have won each of their last seven night games following a loss.
• The Dodgers have covered the run line in each of their last 10 night games at Oracle Park following a loss.
• The Giants have failed to cover the run line in each of their last seven night games against the Dodgers at Oracle Park following a win.
• The Dodgers have led after 5 innings in five of their last six road night games.
• The Dodgers have led after 3 innings in five of their last six games.

Total Runs Facts

• Eight of the Giants’ last nine night games after playing the previous day have gone OVER the total runs line.
• Four of the Dodgers’ last five night games against NL West opponents have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in eight of the Giants’ last nine home games against NL West opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the Dodgers’ last eight night games.

San Francisco Giants Player Prop Facts

• Willy Adames has hit a home run in three of the Giants’ last seven games against NL West opponents.
• Tyler Mahle has recorded five or more strikeouts in nine of his last 11 appearances in night games against NL teams that held a winning record.
• Luis Arraez has recorded at least one hit in each of his last 11 appearances in night games against teams that held a winning record.

Los Angeles Dodgers Player Prop Facts

• Shohei Ohtani has recorded eight or more strikeouts in four of his last five appearances with the Dodgers as favorites against NL opponents.
• Freddie Freeman has recorded at least one hit in each of his last 14 road appearances after playing the previous day.
• Mookie Betts has hit a home run in four of his last six appearances in night games against teams that held a losing record.
• Andy Pages ranks 1st amongst qualified players for Batting Average (.366) this season.

Matchup/League Facts

• The Giants rank 30th in the league for steals this season (5).
• The Giants rank 30th in the league for walks this season (46).
• The Dodgers rank 1st in the league for home runs this season (42).
• The Dodgers rank 1st in the league for batting average this season (.286).

Los Angeles Dodgers vs. San Francisco Giants Prediction

I’m on the Dodgers in this one. I just think that Los Angeles is heads and shoulders the better team in this one, and there’s a clear starting pitching advantage with Ohtani over Mahle that the rivalry aspect can’t overcome here so give me the Dodgers in a bounce back spot here.