San Francisco Giants vs San Diego Padres Prediction 9/13/26 MLB Picks Today

The San Diego Padres and the San Francisco Giants meet Sunday in MLB action from Oracle Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a San Diego Padres vs. San Francisco Giants prediction.

Starting Pitching Matchup

The San Diego Padres will send out Nick Pivetta for the start here and Pivetta is 2-2 with a 3.43 ERA and 26 strikeouts this season. Logan Webb will start for San Francisco and is 8-8 with a 4.10 ERA and 127 strikeouts this season.

San Diego Padres Recap

The San Diego Padres come into this game looking to add on to their 7-6 win over the San Francisco Giants last time out to sit at 80-68 this season. After this series, the Padres will head on the road for a game against the Colorado Rockies.

Padres Win 6 In A Row

Jackson Merrill has 135 hits with 23 doubles, 24 home runs and 79 RBIs while Gavin Sheets has 75 hits with 15 doubles, 16 home runs and 46 RBIs as well on the year. Fernando Tatis Jr. has 161 hits with 29 doubles, 20 home runs and 72 RBIs and Xander Bogaerts has 103 hits with 14 doubles, 11 home runs and 52 RBIs. Manny Machado also has 118 hits with 22 doubles, 26 home runs and 80 RBIs as well on the year.

San Francisco Giants Recap

The San Francisco Giants come into this game looking to bounce back from their loss at the hands of the Padres on Saturday to slip to 62-87 on the year. After this series, the Giants will have a series rematch against the Cardinals on the road.

Giants Drop Back-To-Back Games

Willy Adames has 107 hits with 25 doubles, 21 home runs and 51 RBIs along with 139 strikeouts. Matt Chapman has 72 hits with 18 doubles, a triple, 7 home runs and 42 RBIs and Jung Hoo Lee has 142 hits with 29 doubles, 4 triples, 9 home runs and 55 RBIs. Rafael Devers also has 142 hits with 36 doubles, 35 home runs and 92 RBIs but also has 159 strikeouts this season.

San Diego Padres @ San Francisco Giants Betting Trends: September 13, 2026

• Probable Starting Pitcher: Logan Webb      Record this season: 8-8      ERA: 4.10
• Home Record: 4-4
• Last 5 against Padres: 1-3

Why the San Francisco Giants will win

• The Giants have won three of their last four games as home underdogs after playing the previous day.
• The Padres have lost six of their last seven games following a road win.
• The Padres have failed to cover the run line in seven of their last eight games after playing the previous day.
• The Giants have covered the run line in each of their last five games as underdogs against the Padres following a loss.
• The Giants have won the first inning in each of their last six home games.

• Probable Starting Pitcher: Nick Pivetta      Record this season: 2-2      ERA: 3.43
• Road Record: 0-1
• Last 5 against Giants: 4-0

Why the San Diego Padres will win

• The Padres have won each of their last 12 day games against NL West opponents that held a losing record.
• The Giants have lost each of their last eight day games against NL West opponents that held a winning record.
• The Padres have covered the run line in each of their last seven Sunday road games.
• The Giants have failed to cover the run line in four of their last five home games against the Padres following a home loss.
• The Padres have led after 5 innings in each of their last five games against the Giants.
• The Padres have led after 3 innings in each of their last five Sunday games against NL West opponents that held a losing record.

Total Runs Facts

• Each of the Padres’ last four games have gone OVER the total runs line.
• Each of the last four games between the Padres and Giants have gone OVER the total runs line.
• There has been at least one run scored in the first inning in 12 of the Giants’ last 13 games.
• There has been no run scored during the first inning in seven of the Padres’ last eight day games against NL West opponents.

San Francisco Giants Player Prop Facts

• Rafael Devers has hit a home run in each of the Giants’ last three games against the Padres.
• Logan Webb has recorded a win in four of his last five appearances against NL opponents that held a winning record.
• Logan Webb has recorded six or more strikeouts in six of his last seven home appearances against NL opponents.
• Rafael Devers has recorded at least one hit in each of the Giants’ last 11 games against NL West opponents.
• Rafael Devers ranks 5th amongst qualified players for Slugging Percentage (.525) this season.

San Diego Padres Player Prop Facts

• Jackson Merrill has hit at least one home run in each of the Padres’ last two day games.
• Nick Pivetta has recorded a win in five of his last six appearances in day games against teams that held a losing record.
• Nick Pivetta has recorded five or more strikeouts in each of his last 11 road appearances against opponents that held a losing record.
• Austin Hays has recorded two hits in each of his last seven appearances with his team as a road favorite against NL West opponents.
• Fernando Tatis Jr. ranks 4th in the league in Hits (164) this season.

Matchup/League Facts

• The Giants rank 30th in the league for walks this season (412).
• The Giants rank 1st in the league for home runs allowed this season (142).
• The Padres rank 4th in the league for steals this season (147).
• The Padres rank 25th in the league for doubles this season (215).

San Diego Padres vs. San Francisco Giants Prediction

I’m on the Padres here. Logan Webb historically has been at his best at home and but the problem here is that the Padres have been the better team overall and have been better against right-handed pitching and are looked primed to clinch their spot in the postseason in the coming days. The Giants have just been so inconsistent and I think this is going to be another tough outing to back them. Give me the Padres.