Seattle Mariners vs LA Angels Prediction 9/25/26 MLB Picks Today

The Los Angeles Angels and the Seattle Mariners meet Friday in MLB action from T-Mobile Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Los Angeles Angels vs. Seattle Mariners prediction.

Starting Pitching Matchup

The Los Angeles Angels will start Reid Detmers here and Detmers is 6-8 with a 3.47 ERA and 204 strikeouts this season. Bryce Miller will start for the Mariners and is 4-9 with a 3.99 ERA and 112 strikeouts this season.

Los Angeles Angels Recap

The Los Angeles Angels come into this game looking to add on to their 6-4 win over the Mariners from Thursday’s matchup to sit at 61-98 this season.

Angels Snap Three-Game Slide

Going into Thursday, Zach Neto leads the Angels across the board with a team-high 144 hits, 26 home runs, and 74 RBIs while adding 29 doubles and 5 triples so far this season. Mike Trout has added 124 hits with 26 doubles, 22 home runs, and 54 RBIs, while Nolan Schanuel has contributed 108 hits with 22 doubles, 7 home runs, and 49 RBIs on the year. Jo Adell has logged 101 hits with 16 doubles, a triple, 16 home runs, and 62 RBIs, while Vaughn Grissom has added 99 hits with 22 doubles, 13 home runs, and 70 RBIs. Oswald Peraza has recorded 76 hits with 12 doubles, 2 triples, 7 home runs, and 25 RBIs, and Jorge Soler has chipped in 64 hits with 16 doubles, a triple, 12 home runs, and 49 RBIs for Los Angeles up to this point in the season.

Seattle Mariners Recap

The Seattle Mariners come into this game looking to bounce back from their loss to the Angels to sit at 74-85 on the year.

Mariners Alternate Wins & Losses In 6 Straight

Entering Thursday, Josh Naylor and Randy Arozarena are tied for the Mariners’ team lead with 155 hits each, with Naylor contributing 22 doubles, 10 home runs, and 55 RBIs while Arozarena paces Seattle across the board with a team-high 26 home runs and 76 RBIs along with 31 doubles and a triple so far this season. Julio Rodríguez has added 145 hits with 26 doubles, 21 home runs, and 68 RBIs, while Cole Young has logged 138 hits with 19 doubles, 4 triples, 17 home runs, and 65 RBIs on the year. Cal Raleigh has contributed 79 hits with 15 doubles, 23 home runs, and 68 RBIs, and Luke Raley has chipped in 59 hits with 9 doubles, a triple, 15 home runs, and 39 RBIs for Seattle up to this point in the season.

Los Angeles Angels @ Seattle Mariners Betting Trends: September 25, 2026

• Probable Starting Pitcher: Bryce Miller      Record this season: 4-9      ERA: 3.99
• Home Record: 1-5
• Last 5 against Angels: 2-2

Why the Seattle Mariners will win

• The Angels have lost 12 of their last 13 night games against AL opponents following a road win.
• The Mariners have won nine of their last 10 home games against the Angels.
• The Angels have failed to cover the run line in seven of their last eight games.
• The Angels have trailed after 5 innings in each of their last four games as underdogs.
• The Angels have trailed after 3 innings in five of their last six games.

• Probable Starting Pitcher: Reid Detmers      Record this season: 6-8      ERA: 3.47
• Road Record: 4-3
• Last 5 against Mariners: 1-0

Why the Los Angeles Angels will win

• The Mariners have lost each of their last seven Friday games as favorites against AL opponents.
• The underdogs have won each of the Angels’ last three games.
• The Mariners have failed to cover the run line in each of their last 12 Friday games.
• The Angels have covered the run line in each of their last six games as road underdogs.
• The Mariners have trailed after 3 innings in four of their last five home night games.
• The Mariners have trailed after 5 innings in each of their last six Friday games against AL opponents that held a losing record.

Total Runs Facts

• Each of the Angels’ last five road games have gone OVER the total runs line.
• Thirteen of the Mariners’ last 15 night games against AL opponents have gone OVER the total runs line.
• There has been at least one run scored in the first inning in nine of Bryce Miller’s last 10 appearances as a starter.
• There has been no run scored during the first inning in each of the Angels’ last five games as road underdogs against AL opponents.

Seattle Mariners Player Prop Facts

• Cal Raleigh has hit at least one home run in seven of the Mariners’ last 20 night games.
• Julio Rodriguez has recorded at least one hit in each of the Mariners’ last 10 games as favorites against AL West opponents.
• Randy Arozarena ranks 10th amongst qualified players for On Base Percentage (.380) this season.

Los Angeles Angels Player Prop Facts

• Mike Trout has hit at least one home run in eight of his last 14 appearances at T-Mobile Park against opponents that held a losing record.
• Reid Detmers has recorded eight or more strikeouts in five of his last six appearances in night games against AL West teams that held a losing record.
• Zach Neto has recorded at least one hit in each of the Angels’ last 11 road games against AL West opponents.
• Mike Trout ranks 6th amongst qualified players for On Base Percentage (.385) this season.

Matchup/League Facts

• The Mariners rank 30th in the league for doubles this season (200).
• The Mariners rank 29th in the league for hits this season (1222).
• The Angels rank 30th in the league for slugging percentage this season (.369).
• The Angels rank 30th in the league for strikeouts against this season (1520).

Los Angeles Angels vs. Seattle Mariners Prediction

I’m on the Angels in this one. I thought Seattle’s best chance with a pitching edge was Thursday with Bryan Woo pitching, but that didn’t end up being the case and I think that the Angels get another one here. Bryce Miller’s game has been questionable in the last couple of months and I’m back to not being able to trust Seattle’s game against lefties. I think that Detmers has a strong showing here and that the Angels deliver another win in this one so give me the Angels.