Mariners vs Padres Prediction 8/27/25 MLB Picks Today

The San Diego Padres and the Seattle Mariners meet Wednesday in MLB action from T-Mobile Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Mariners vs Padres Prediction.

Starting Pitching Matchup

The San Diego Padres will send out Yu Darvish for the start here and Darvish is 3-3 with a 5.36 ERA and 39 strikeouts this season. In his last five starts against Seattle, Darvish is 3-1 with a 2.32 ERA and 27 strikeouts. Bryan Woo will get the start for the Mariners here and is 11-7 with a 2.94 ERA and 160 strikeouts this season. In his career, Woo is 2-0 with a 1.98 ERA and 10 strikeouts against the Padres.

San Diego Padres Recap

The San Diego Padres come into this game looking to build on their 7-6 win over the Mariners from Tuesday’s matchup to sit at 75-58 this season. After this series, the Padres will head on the road for an interleague series against the Minnesota Twins.

Padres Snap Two-Game Slide

Manny Machado has 145 hits including a team-high 32 doubles, 21 home runs, 77 RBIs and 12 stolen bases while Fernando Tatis Jr. has 128 hits with 17 home runs and 52 RBIs along with 25 stolen bases of his own this season. Luis Arraez has added 144 hits with 27 doubles, 4 triples, 6 home runs and 47 RBIs while Jackson Merrill’s added 91 hits with 9 home runs and 51 RBIs as well. Xander Bogaerts also has 28 doubles and 19 stolen bases as well this season. Gavin Sheets also has 18 doubles, 17 home runs and 58 RBIs as well this season.

Why the San Diego Padres will win

• The underdogs have won seven of the last eight games between the Padres and Mariners.
• The Mariners have lost four of their last five games as favorites against National League opponents.
• The Padres have covered the run line in 12 of their last 13 games as underdogs following a win.
• The Mariners have failed to cover the run line in eight of their last nine games as favorites against National League opponents.

San Diego Padres Player Prop Facts

• Fernando Tatis Jr. has hit a home run in three of the Padres’ last four road games against the Mariners.
• Luis Arraez has recorded a Double in four of the Padres’ last five road games against AL opponents.
• Yu Darvish has recorded a win in five of his last six appearances against AL West opponents.
• Yu Darvish has recorded five or more strikeouts in 12 of his last 13 appearances against the Mariners.
• Xander Bogaerts has recorded at least one hit in each of his last 11 road appearances against the Mariners after playing the previous day.
• Manny Machado ranks 4th in the league in Hits (149) this season.

Seattle Mariners Recap

The Seattle Mariners come into this game looking to rebound from their loss at the hands of the Padres on Tuesday to fall to 71-62 this season. After this series, the Mariners will head on the road for a series against the Cleveland Guardians.

Mariners Drop 7 Of Their Last 10

Jorge Polanco has 87 hits including 18 home runs and 54 RBIs while Cal Raleigh has 116 hits with 19 doubles, a team-high 47 home runs and 102 RBIs. Randy Arozarena has 114 hits with 25 doubles, 23 home runs, 59 RBIs and 24 stolen bases. Julio Rodriguez also has 138 hits with 24 doubles, 4 triples, 25 home runs, 71 RBIs and 23 stolen bases. Dylan Moore has 9 homers and 12 stolen bases as well this season. J.P Crawford has 122 hits with 19 doubles, 9 home runs and 44 RBIs.

Why the Seattle Mariners will win

• The Mariners have won nine of their last 10 games at T-Mobile Park following a loss.
• The Padres have lost each of their last five games against the Mariners following a win.
• The Padres have failed to cover the run line in nine of their last 10 road games against American League opponents following a win.
• The Mariners have covered the run line in each of their last five games against the Padres following a loss.

Seattle Mariners Player Prop Facts

• J.P. Crawford has recorded a Double in six of his last eight home appearances against NL West opponents that held a winning record.
• Cal Raleigh has hit at least one home run in three of the Mariners’ last four games as favorites against the Padres.
• Victor Robles has recorded at least one hit in each of his last 11 appearances in day games.
• Cal Raleigh ranks 1st in the league in Home Runs (50) this season.

Total Runs Facts

• Each of the Padres’ last six day games against AL West opponents have gone UNDER the total runs line.
• Each of the Mariners’ last six games against National League opponents have gone OVER the total runs line.

Mariners vs Padres Prediction

I’m siding with the Mariners here. I think that Bryan Woo is the better starter in this matchup, as you’ve yet to have a start this season where he has not managed to go at least 6 innings in the start. Yu Darvish has been up and down and while the Padres eked one out on Tuesday, I think the Mariners get their revenge here behind their ace. Give me Seattle in this one.