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Mariners vs Cardinals Prediction 9/9/25 MLB Picks Today

St. Louis Cardinals (72-73) vs. Seattle Mariners (76-68)
September 9, 2025 9:40 pm EDT
The Line: Seattle Mariners -205 / St. Louis Cardinals +167; Over/Under: 7.5
(Get latest betting odds)

The St. Louis Cardinals and the Seattle Mariners meet Tuesday in MLB action from T-Mobile Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Mariners vs Cardinals Prediction.

Starting Pitching Matchup

The St. Louis Cardinals will send out Matthew Liberatore for the start here and Liberatore is 7-11 with a 4.15 ERA and 109 strikeouts this season. This will be Liberatore’s first career start against the Mariners. George Kirby will get the nod for the Mariners here and is 8-7 with a 4.47 ERA and 104 strikeouts this season. this will be Kirby’s second career start against the Cardinals.

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game looking to rebound from their 4-2 loss at the hands of the Mariners in Monday’s series opener. After this series, the Cardinals will head on the road for a series against the Milwaukee Brewers.

Cardinals Win 4 Of Last 6 Despite Loss On Monday

Brendan Donovan has a team-high 118 hits along with 25 doubles, 9 home runs and 45 RBIs while Lars Nootbaar has 109 hits with 13 home runs, 45 RBIs, 22 doubles and 4 stolen bases. Nolan Arenado also has 85 hits with 15 doubles, 10 home runs and 43 RBIs of his own and Victor Scott II has 81 hits with 14 doubles, a triple, 36 RBIs and a team-high 31 stolen bases. Willson Contreras has also chipped in 120 hits with 30 doubles, 20 home runs and 78 RBIs of his own as well this season. Masyn Winn’s added 124 hits with 27 doubles, 9 home runs and 51 RBIs and Alec Burleson’s added 124 hits with 21 doubles, 17 home runs and 62 RBIs.

Why the St. Louis Cardinals will win

  • The Cardinals have won each of their last five games as underdogs against AL West opponents following a loss.
  • The Mariners have lost three of their last four games as favorites following a home win.
  • The Cardinals have covered the run line in each of their last seven games against the Mariners following a loss.
  • The Mariners have failed to cover the run line in eight of their last nine games as favorites against National League opponents following a home win.

St. Louis Cardinals Player Prop Facts

  • Alec Burleson has hit a home run in each of the Cardinals’ last three road games against AL opponents that held a winning record.
  • Alec Burleson has recorded at least one hit in each of his last 10 road appearances against AL opponents.
  • Victor Scott II ranks 10th in the league in Steals (31) this season.

Seattle Mariners Recap

The Seattle Mariners come into this game looking to add on to their win over the Cardinals from Monday’s matchup to sit at 76-68 this season. After this series, the Mariners will take on the Los Angeles Angels in a division series at home.

Mariners Win Three In A Row

Jorge Polanco has 106 hits including 24 home runs and 67 RBIs while Cal Raleigh has 128 hits with 19 doubles, a team-high 53 home runs and 113 RBIs. Randy Arozarena has 131 hits with 30 doubles, 26 home runs, 69 RBIs and 27 stolen bases. Julio Rodriguez also has 158 hits with 26 doubles, 4 triples, 30 home runs, 90 RBIs and 25 stolen bases. J.P Crawford has 134 hits with 20 doubles, 9 home runs and 47 RBIs.

Why the Seattle Mariners will win

  • The Mariners have won 11 of their last 12 home games against teams that held a losing record.
  • The Cardinals have lost eight of their last nine games against American League opponents that held a winning record.
  • The Cardinals have failed to cover the run line in six of their last seven night games against AL West opponents that held a winning record.
  • The favorites have covered the run line in four of the last five games between the Cardinals and Mariners.

Seattle Mariners Player Prop Facts

  • Cal Raleigh has hit a home run in three of the Mariners’ last four games against opponents that held a losing record.
  • George Kirby has recorded seven or more strikeouts in four of his last five appearances against opponents that held a losing record.
  • George Kirby has recorded a win in five of his last six appearances against opponents that held a losing record.
  • Jorge Polanco has recorded a Double in four of the Mariners’ last five home games against NL opponents.
  • Randy Arozarena has recorded at least one hit in each of his last 10 home appearances against former teams.
  • Cal Raleigh ranks 1st in the league in Home Runs (53) this season.

Total Runs Facts

  • Eight of the Mariners’ last nine home games against NL Central opponents have gone UNDER the total runs line.
  • Each of the Cardinals’ last five games after playing the previous day have gone UNDER the total runs line.

Mariners vs Cardinals Prediction

I’m on the Mariners in this one. I just can’t trust Matthew Liberatore in this spot, and I think that the Mariners, who once again found a way to pull one out of the fire, can get to Liberatore here. The Mariners have a clear edge in starting pitching with George Kirby going here, and I look for Kirby to pitch a gem against this inconsistent Cardinals offense and to get the win here. Give me Seattle.

Chris Ruffolo's Free Pick: Seattle Mariners -205

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Chris Ruffolo

Chris joined the Sports Chat Place team in August 2016 and has a proven system that combines multiple analytical and situational statistics and trends to give out thousands of winning picks over the last three years with winning records across all of the top leagues, Follow Chris Ruffolo on Twitter @ruffthepickdawg

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