St. Louis Cardinals vs Baltimore Orioles Prediction 8/27/26 MLB Picks Today

The Baltimore Orioles and the St. Louis Cardinals meet Thursday in MLB action from Busch Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Baltimore Orioles vs. St. Louis Cardinals prediction.

Starting Pitching Matchup

The Baltimore Orioles will send out Trevor Rogers for the start here and Rogers is 9-8 with a 4.14 ERA and 114 strikeouts this season. The St. Louis Cardinals did not have a starting pitcher announced at the time that this article was posted.

Baltimore Orioles Recap

The Baltimore Orioles come into this game looking to add on to their 8-7 win over the Cardinals from Wednesday’s matchup to improve to 65-68 this season. After this series, the Orioles will take on the Athletics in a series on the road.

Orioles Win 4 Of Last 5

Gunnar Henderson has 115 hits with 23 doubles, 20 home runs and 51 RBIs and Pete Alonso has 137 hits with 24 doubles, 31 home runs and 89 RBIs. Jeremiah Jackson has 53 hits with 10 doubles, 7 home runs and 39 RBIs as well on the year. Samuel Basallo has 70 hits with 9 doubles, 17 home runs and 48 RBIs.

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game looking to rebound from their loss at the hands of Baltimore last time out to sit at 66-67 this season. After this series, the Cardinals will take on the Pittsburgh Pirates in a series at home.

Cardinals Lose 5 In A Row

Jordan Walker has 144 hits, 28 doubles, 27 home runs and 96 RBIs while Alec Burleson has 146 hits with 33 doubles, 21 home runs and 96 RBIs. JJ Wetherholt has 121 hits with 17 home runs and 48 RBIs while Ivan Herrera has 120 hits with 23 doubles, 14 home runs and 53 RBIs. Masyn Winn’s added 103 hits with 19 doubles and 51 RBIs and Nathan Church has 77 hits with 9 home runs and 41 RBIs this season.

Baltimore Orioles @ St. Louis Cardinals Betting Trends: August 27, 2026

• Probable Starting Pitcher: TBD

Why the St. Louis Cardinals will win

• The Cardinals have won five of their last six games as underdogs against the Orioles.
• The Orioles have lost five of their last six games as road favorites against NL opponents following a road win.
• The Orioles have failed to cover the run line in each of their last eight games as favorites against NL Central opponents following a road win.
• The Cardinals have covered the run line in each of their last six games as underdogs against the Orioles.
• The Cardinals have led after 5 innings in eight of their last nine day games.
• The Cardinals have won the first inning in each of their last five day games.
• The Cardinals have led after 3 innings in seven of their last eight home day games.

• Probable Starting Pitcher: Trevor Rogers      Record this season: 9-8      ERA: 4.14
• Road Record: 4-3
• Last 5 against Cardinals: 0-2

Why the Baltimore Orioles will win

• The Cardinals have lost each of their last nine games against AL East opponents following a home loss.
• The Orioles have won seven of their last eight games against NL Central opponents that held a losing record.
• The Orioles have covered the run line in five of their last six road games.
• The Cardinals have failed to cover the run line in six of their last seven day games against AL opponents following a home loss.
• The Orioles have won the first inning in three of their last four games as road favorites against NL opponents.
• The Orioles have led after 3 innings in five of their last six games against the Cardinals.
• The Orioles have led after 5 innings in five of their last six day games against the Cardinals.

Total Runs Facts

• Each of the Cardinals’ last seven games have gone OVER the total runs line.
• Each of the Orioles’ last four road games have gone OVER the total runs line.
• There has been no run scored during the first inning in seven of Trevor Rogers’ last eight appearances as a starter.
• There has been at least one run scored in the first inning in each of the Cardinals’ last five day games.

St. Louis Cardinals Player Prop Facts

• JJ Wetherholt has hit at least one home run in three of his last four appearances in day games against AL teams that held a losing record.
• Alec Burleson has recorded at least one hit in each of the Cardinals’ last 12 games.
• Alec Burleson ranks T5th in the league in Hits (147) this season.

Baltimore Orioles Player Prop Facts

• Pete Alonso has hit a home run in four of the Orioles’ last five road games.
• Trevor Rogers has recorded a win in each of his last four road appearances against NL opponents.
• Trevor Rogers has recorded six or more strikeouts in each of his last four appearances with the Orioles as favorites.
• Pete Alonso has recorded at least one hit in each of the Orioles’ last 11 road games.
• Pete Alonso ranks 8th in the league in Home Runs (32) this season.

Matchup/League Facts

• The Cardinals rank 27th in the league for doubles this season (189).
• The Cardinals rank 26th in the league for slugging percentage this season (.382).
• The Orioles rank 3rd in the league for walks this season (497).
• The Orioles rank 27th in the league for strikeouts against this season (1222).

Baltimore Orioles vs. St. Louis Cardinals Prediction

I’m backing Baltimore in this game. The Orioles just look like the team with far more motivation in a wide open AL Wild Card race, while St. Louis just looks like they’ve run into a wall and are more content with playing out the string at this point. I think this is just a tough spot for the Cardinals to be in and for St. Louis to get the job done in this game. Give me the Orioles.