Cardinals vs Cubs Prediction 8/8/25 MLB Picks Today

The Chicago Cubs and the St. Louis Cardinals meet Friday in MLB action from Busch Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Cardinals vs Cubs Prediction.

Starting Pitching Matchup

The Chicago Cubs will send out Matthew Boyd for the start here and Boyd is 11-4 with a 2.34 ERA and 118 strikeouts this season. In his last five starts against the Cardinals, Boyd is 3-1 with a 1.29 ERA and 35 strikeouts. Michael McGreevy will get the start for the Cardinals in this one and is 3-2 with a 5.08 ERA and 23 strikeouts this season. This will be McGreevy’s second career start against the Cubs.

Chicago Cubs Recap

The Chicago Cubs come into this game looking to add on to their 6-1 win over the Cincinnati Reds last time out to sit at 66-48 on the year. After this series, the Cubs will head on the road for a series against the Toronto Blue Jays.

Cubs Looking To Rebound From Series Loss

Ian Happ has 93 hits with 19 doubles, 16 home runs and 54 RBIs. Kyle Tucker has 111 hits including 21 doubles, 4 triples, 18 home runs and 61 RBIs while Seiya Suzuki also has 107 hits with 25 doubles and 27 home runs and 84 RBIs of his own. Pete Crow-Armstrong also has contributed 115 hits, 31 doubles, 4 triples, 27 home runs and 78 RBIs as well this season. Dansby Swanson has added 18 home runs and 55 RBIs, while also having 130 strikeouts and Suzuki has 127 strikeouts so far this season. Crow-Armstrong also has a team-high 29 stolen bases while Nico Hoerner has 19 stolen bases this season. Tucker’s also added 23 stolen bases while Michael Busch has also chipped in 15 doubles, 3 triples, 21 home runs and 61 RBIs this season.

Why the Chicago Cubs will win

• The Cardinals have lost each of their last six games against the Cubs following a road win.
• The Cubs have won each of their last five night games against the Cardinals following a win.
• The Cardinals have failed to cover the run line in 11 of their last 12 games against National League opponents following a win.
• The Cubs have covered the run line in four of their last five games against the Cardinals.

Chicago Cubs Player Prop Facts

• Carson Kelly has hit a home run in each of his last two appearances with the Cubs as favorites against the Cardinals.
• Nico Hoerner has recorded at least one hit in each of the Cubs’ last 13 games as road favorites.
• Matthew Boyd has recorded a win in four of his last five appearances in night games.
• Matthew Boyd ranks T4th in the league for Wins (11) this season.

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game looking to build on their 5-3 win over the Los Angeles Dodgers last time out to sit at 58-58 this season. After this series, the Cardinals will welcome the Colorado Rockies to town for a series.

Cardinals Alternate Wins & Losses In 6 Straight

Brendan Donovan has a team-high 115 hits along with 24 doubles, 9 home runs and 43 RBIs while Lars Nootbaar has 80 hits with 12 home runs, 40 RBIs, 16 doubles and 4 stolen bases. Nolan Arenado also has 85 hits with 15 doubles, 10 home runs and 43 RBIs of his own and Victor Scott II has 75 hits with 13 doubles, a triple, 33 RBIs and a team-high 29 stolen bases. Willson Contreras has also chipped in 103 hits with 29 doubles, 16 home runs and 64 RBIs of his own as well this season. Masyn Winn’s added 106 hits with 24 doubles, 8 home runs and 42 RBIs and Alec Burleson’s added 100 hits with 19 doubles, 14 home runs and 50 RBIs.

Why the St. Louis Cardinals will win

• The Cubs have lost six of their last seven games as favorites against the Cardinals following a home win.
• The underdogs have won five of the Cardinals’ last six games at Busch Stadium.
• The Cubs have failed to cover the run line in each of their last seven games following a win.
• The underdogs have covered the run line in five of the Cardinals’ last six games at Busch Stadium.

St. Louis Cardinals Player Prop Facts

• Lars Nootbaar has recorded at least one hit in each of his last seven appearances against the Cubs after not playing the previous day.
• Lars Nootbaar has hit a home run in each of his last two home appearances against the Cubs.
• Victor Scott II ranks T8th in the league in Steals (29) this season.

Total Runs Facts

• Each of the Cubs’ last four road games have gone OVER the total runs line.
• Each of the Cardinals’ last three games against NL Central opponents have gone OVER the total runs line.

Cardinals vs Cubs Prediction

I’m on the Cubs here. I just think the Cubs are the better team and the Cardinals kind of look like a team that’s running out of gas and are struggling to find consistency. Chicago has been the much more consistent team with their diamond in the rough going in Matthew Boyd who has been outstanding for much of the year. I think the Cubs draw first blood here. Give me Chicago.