St. Louis Cardinals vs Cincinnati Reds Prediction 6/6/26 MLB Picks Today

The Cincinnati Reds and the St. Louis Cardinals meet Saturday in MLB action from Busch Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Cincinnati Reds vs. St. Louis Cardinals prediction.

Starting Pitching Matchup

The Cincinnati Reds will send out Nick Lodolo and Lodolo is 2-1 with a 5.20 ERA and 22 strikeouts this season. In his career, Lodolo is 2-1 with a 4.85 ERA and 15 strikeouts against the Cardinals. Matthew Liberatore will start for St. Louis and is 3-3 with a 4.35 ERA and 57 strikeouts this season. In his career, Liberatore is 0-1 with a 4.50 ERA and 12 strikeouts against the Reds.

Cincinnati Reds Recap

The Cincinnati Reds come into this game looking to bounce back from a 10-3 loss at the hands of St. Louis on Friday to sit at 31-31 this season. After this series, the Reds will head on the road again for a series against the San Diego Padres.

Reds Drop 6 Of Last 8

Elly De La Cruz has 65 hits with 13 doubles, 2 triples, 12 home runs and 37 RBIs while Sal Stewart has 61 hits with 13 doubles, 12 home runs and 39 RBIs. Spencer Steer has 58 hits with 12 doubles, 9 home runs and 23 RBIs and Matt McLain has 40 hits with 10 doubles, 5 home runs and 21 RBIs. JJ Bleday’s added 26 hits with 8 doubles, 10 home runs and 27 RBIs as well on the year.

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game looking to add on to their win over the Reds from Friday to sit at 33-28 this season. After this series, the Cardinals will head on the road for a series against the New York Mets.

Cardinals Win Back-To-Back Games

Jordan Walker leads the Cardinals with 69 hits, 13 doubles, 15 home runs and 45 RBIs while Alec Burleson has 68 hits with 15 doubles, 8 home runs and 43 RBIs. JJ Wetherholt has 56 hits with 9 home runs and 25 RBIs while Ivan Herrera has 59 hits with 12 doubles, 7 home runs and 28 RBIs. Nolan Gorman has 39 hits with 7 home runs and 26 RBIs this season. Masyn Winn’s added 47 hits with 8 doubles and 22 RBIs and Nathan Church has 36 hits with 5 home runs and 18 RBIs this season.

Cincinnati Reds @ St. Louis Cardinals Betting Trends: June 6, 2026

• Probable Starting Pitcher: Matthew Liberatore      Record this season: 3-3      ERA: 4.35
• Home Record: 2-1
• Last 5 against Reds: 0-1

Why the St. Louis Cardinals will win

• The Reds have lost each of their last nine road games against NL Central opponents.
• The favorites have won each of the Cardinals’ last six games.
• The Reds have failed to cover the run line in seven of their last eight games.
• The favorites have covered the run line in five of the Cardinals’ last six games.
• The Cardinals have led after 3 innings in four of their last five games against the Reds.
• The Reds have trailed after 5 innings in five of their last six day games against NL Central opponents.

• Probable Starting Pitcher: Nick Lodolo      Record this season: 2-1      ERA: 5.20
• Road Record: 1-0
• Last 5 against Cardinals: 2-1

Why the Cincinnati Reds will win

• The Cardinals have lost four of their last five games as favorites against NL Central opponents following a win.
• The underdogs have won six of the last nine games between the Reds and Cardinals.
• The Cardinals have failed to cover the run line in 13 of their last 14 games as favorites against National League opponents following a home win.
• The Reds have covered the run line in each of their last five day games against the Cardinals following a loss.
• The Reds have led after 3 innings in four of their last five day games against National League opponents.
• The Cardinals have trailed after 5 innings in four of their last five home day games.
• The Cardinals have lost the first inning in three of their last four day games at Busch Stadium.

Total Runs Facts

• Seven of the Cardinals’ last eight day games after playing the previous day have gone UNDER the total runs line.
• Each of the Reds’ last four games as underdogs against the Cardinals have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Cardinals’ last four day games at Busch Stadium.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the Reds’ last six games at Busch Stadium.

St. Louis Cardinals Player Prop Facts

• Alec Burleson has hit a home run in each of the Cardinals’ last two home games against the Reds.
• Alec Burleson has recorded two hits in each of the Cardinals’ last three games.
• Jordan Walker ranks T9th in the league in Hits (69) this season.

Cincinnati Reds Player Prop Facts

• Nick Lodolo has recorded a win in three of his last four appearances in day games.
• Nick Lodolo has recorded five or more strikeouts in seven of his last nine appearances in day games.
• JJ Bleday has recorded at least one hit in each of the Reds’ last seven road games against NL Central opponents.
• Elly De La Cruz has hit a home run in two of his last three appearances with the Reds as underdogs against the Cardinals.
• Sal Stewart is one of only six players to record 10+ Home Runs and 10+ Stolen Bases this season.

Matchup/League Facts

• The Cardinals rank T27th in the league for triples this season (5).
• The Cardinals rank 27th in the league for strikeouts this season (472).
• The Reds rank 29th in the league for hits this season (477).
• The Reds rank 28th in the league for strikeouts against this season (580).

Cincinnati Reds vs. St. Louis Cardinals Prediction

I’m on the Reds here. In a lefty-lefty matchup on the mound, the Reds are the team I trust a lot more in this situation as they’ve had much better numbers against southpaws in recent weeks. The Reds aren’t in the best form, and the bullpen is shaky, but I think Lodolo has a strong start here and gets the Reds the W.