Cardinals vs Giants Prediction 9/5/25 MLB Picks Today

The San Francisco Giants and the St. Louis Cardinals meet Friday in MLB action from Busch Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Cardinals vs Giants Prediction.

Starting Pitching Matchup

The San Francisco Giants will send out Carson Seymour for the start here and Seymour is 0-2 with a 4.74 ERA and 18 strikeouts this season. This will be Seymour’s first career start against the Cardinals. The St. Louis Cardinals will send out Michael McGreevy for the start here and is 6-2 with a 4.17 ERA and 40 strikeouts this season. This will be McGreevy’s second career start against the Giants.

San Francisco Giants Recap

The San Francisco Giants come into this game looking to build on their 10-8 win over the Colorado Rockies last time out to sit at 70-71 on the year. After this series, the Giants will head home for a series against the Arizona Diamondbacks.

Giants Win 4 Straight and 9 Of Last 10

Jung Hoo Lee has 129 hits including a team-high 30 doubles along with 10 triples, 7 home runs and 48 RBIs with 10 stolen bases while Heliot Ramos has 143 hits with 23 doubles, 16 home runs and 59 RBIs. Wilmer Flores also 15 home runs and 67 RBIs while Tyler Fitzgerald has 9 stolen bases as well on the year. Matt Chapman also has 89 hits with 20 home runs and 64 RBIs along with 17 doubles and Willy Adames has 118 hits with 18 doubles, 26 home runs and 76 RBIs of his own this season. 

Why the San Francisco Giants will win

• The Giants have won each of their last eight games against National League opponents.
• The Cardinals have lost eight of their last nine games as favorites following a win.
• The Cardinals have failed to cover the run line in each of their last 12 games as favorites following a home win.
• The Giants have covered the run line in each of their last seven games as underdogs against NL Central opponents.

San Francisco Giants Player Prop Facts

• Rafael Devers has hit a home run in each of his three previous road appearances against the Cardinals.
• Dominic Smith has recorded at least one hit in each of his last 17 appearances in night games.
• Wilmer Flores has recorded a Double in four of his last five appearances at Busch Stadium.
• Rafael Devers ranks 9th amongst qualified players for On Base Percentage (.380) this season.

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game looking to add on to their 5-1 win over the Athletics last time out to sit at 70-71 on the year. After this series, the Cardinals will head on the road for a series against the Seattle Mariners.

Cardinals Win Back-To-Back Games

Brendan Donovan has a team-high 118 hits along with 25 doubles, 9 home runs and 45 RBIs while Lars Nootbaar has 106 hits with 13 home runs, 44 RBIs, 22 doubles and 4 stolen bases. Nolan Arenado also has 85 hits with 15 doubles, 10 home runs and 43 RBIs of his own and Victor Scott II has 79 hits with 14 doubles, a triple, 35 RBIs and a team-high 31 stolen bases. Willson Contreras has also chipped in 120 hits with 30 doubles, 20 home runs and 78 RBIs of his own as well this season. Masyn Winn’s added 122 hits with 27 doubles, 9 home runs and 51 RBIs and Alec Burleson’s added 123 hits with 21 doubles, 16 home runs and 60 RBIs.

Why the St. Louis Cardinals will win

• The favorites have won each of the Giants’ last seven games.
• The Giants have lost six of their last seven night games against NL Central opponents following a road win.
• The Cardinals have covered the run line in each of their last six games against the Giants.
• The Giants have failed to cover the run line in six of their last seven night games against NL Central opponents that held a losing record.

St. Louis Cardinals Player Prop Facts

• Masyn Winn has recorded a Double in four of his five previous appearances against the Giants.
• Lars Nootbaar has hit a home run in two of his last three home appearances against NL opponents that held a winning record.
• Brendan Donovan has recorded at least one hit in each of the Cardinals’ last nine games against the Giants.
• Victor Scott II ranks T9th in the league in Steals (31) this season.

Total Runs Facts

• Each of the Cardinals’ last seven games as favorites against the Giants have gone OVER the total runs line.
• Five of the Giants’ last six games have gone OVER the total runs line.

Cardinals vs Giants Prediction

I’m on the Giants in this one. I get the case to be made for the Cardinals at home, but the Giants are just in better form right now and are surprisingly solid against right-handed pitching as of late over this run they’ve been on. The Cardinals continue to be so hit or miss offensively, and I just can’t trust them in a spot like this. Give me the Giants here.