St. Louis Cardinals vs Seattle Mariners Prediction 4/24/26 MLB Picks Today

The Seattle Mariners and the St. Louis Cardinals meet Friday in MLB action from Busch Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Seattle Mariners vs. St. Louis Cardinals prediction.

Starting Pitching Matchup

The Seattle Mariners will send out George Kirby for the start here and Kirby is 3-2 with a 2.97 ERA and 27 strikeouts this sesaon. In his career, Kirby is 1-0 with a 4.50 ERA and 7 strikeouts against the Cardinals. The St. Louis Cardinals will trot out Andre Pallante here and Pallante is 2-1 with a 4.05 ERA and 12 strikeouts this season. This will be Pallante’s first career start against the Mariners.

Seattle Mariners Recap

The Seattle Mariners come into this game looking to add on to their 5-4 win over the Athletics last time out to sit at 11-15 this season. After this series, the Mariners will head on the road for a series against the Minnesota Twins.

Mariners Avoid Sweep Vs. Athletics

Brendan Donovan has 17 hits with 3 doubles, 3 home runs and 8 RBIs while Luke Raley has 5 home runs and 13 RBIs this season. Cole Young’s added 21 hits with 2 doubles, a triple, 2 home runs and 11 RBIs and Cal Raleigh has 20 hits with 4 doubles, 5 home runs and 14 RBIs as well this season. Randy Arozarena has 27 hits with 6 doubles, 2 home runs and 10 RBIs as well on the year. Josh Naylor also has 18 hits with 2 home runs and 10 RBIs as well on the year. Julio Rodriguez has also added 24 hits with 3 doubles, a home run and 8 RBIs.

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game looking to shake off a 4-1 loss at the hands of the Miami last time out to sit at 14-10 this season. After this series, St. Louis will take on the Pittsburgh Pirates on the road.

Cardinals Alternate Wins & Losses In 4 Straight

Jordan Walker leads the Cardinals with 26 hits, 4 doubles, 8 home runs and 16 RBIs while Alec Burleson has 25 hits with 6 doubles, 3 home runs and 17 RBIs. JJ Wetherholt has 19 hits with 3 home run and 11 RBIs while Ivan Herrera has 20 hits with 4 doubles and 12 RBIs. Nolan Gorman has 16 hits with 3 home runs and 15 RBIs this season.

Seattle Mariners @ St. Louis Cardinals Betting Trends: April 24, 2026

• Probable Starting Pitcher: Andre Pallante      Record this season: 2-1      ERA: 4.05
• Home Record: 1-1
• Last 5 against Mariners: –

Why the St. Louis Cardinals will win

• The Mariners have lost each of their last six games as road favorites.
• The Cardinals have won each of their last four games as underdogs against American League opponents.
• The Mariners have failed to cover the run line in each of their last six games as road favorites.
• The Cardinals have covered the run line in each of their last five games against American League opponents.
• The Cardinals have won the first inning in each of their last three night games against AL West opponents.
• The Mariners have trailed after 3 innings in eight of their last 10 night games against National League opponents that held a winning record.
• The Mariners have trailed after 5 innings in each of their last six games as road favorites.

• Probable Starting Pitcher: George Kirby      Record this season: 3-2      ERA: 2.97
• Road Record: 0-1
• Last 5 against Cardinals: 1-0

Why the Seattle Mariners will win

• The Mariners have won each of their last four games against the Cardinals.
• The Cardinals have lost four of their last five night games against the Mariners following a road loss.
• The Mariners have covered the run line in each of their last four games against the Cardinals.
• The Cardinals have failed to cover the run line in three of their last four games as home underdogs.
• The Mariners have won the first inning in each of their last four games as road favorites against NL Central opponents.
• The Mariners have led after 3 innings in three of their last four games as road favorites against NL Central opponents.
• The Mariners have led after 5 innings in four of their last five night games against the Cardinals at Busch Stadium.

Total Runs Facts

• Each of the Cardinals’ last seven games as underdogs against American League opponents have gone OVER the total runs line.
• Each of the Mariners’ last four games as road favorites have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Mariners’ last seven road games against NL Central opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the last six night games between the Mariners and Cardinals at Busch Stadium.

St. Louis Cardinals Player Prop Facts

• Ramon Urias has hit a home run in two of his last three home appearances against AL West opponents.
• Ramon Urias has recorded at least one hit in each of his last nine home appearances against AL West opponents.
• Jordan Walker ranks T5th in the league in Home Runs (8) this season.

Seattle Mariners Player Prop Facts

• Cal Raleigh has hit at least one home run in each of the Mariners’ last five road games against NL Central opponents.
• George Kirby has recorded six or more strikeouts in each of his last six Friday night appearances against teams that held a winning record.
• Cal Raleigh has recorded at least one hit in each of his last 10 appearances against NL Central opponents that held a winning record.
• George Kirby ranks T6th in the league for Wins (3) this season.

Matchup/League Facts

• The Cardinals rank 30th in the league for strikeouts this season (154).
• The Cardinals rank 28th in the league for hits this season (183).
• The Mariners rank 1st in the league for walks allowed this season (63).
• The Mariners rank 4th in the league for ERA this season (3.42).

Seattle Mariners vs. St. Louis Cardinals Prediction

I’m on the Mariners here. I think that Pallante is the weak link of the Cardinals’ rotation and I think the Mariners are starting to pick it up after a slow start out of the gate at the plate. I think Kirby is the far stronger starting option in this game and I still believe the Mariners have one of the better bullpens in baseball across the board. Give me the Mariners in this one.