St. Louis Cardinals vs Seattle Mariners Prediction 4/25/26 MLB Picks Today

The Seattle Mariners and the St. Louis Cardinals meet Saturday in MLB action from Busch Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Seattle Mariners vs. St. Louis Cardinals prediction.

Starting Pitching Matchup

The Seattle Mariners will send out Bryan Woo for the start here and Woo is 1-2 with a 2.25 ERA and 26 strikeouts this season. This will be Woo’s second career start against St. Louis. The St. Louis Cardinals will trot out Matthew Liberatore for the start here and Liberatore is 0-1 with a 3.67 ERA and 16 strikeouts this season. This will be Liberatore’s second career start against Seattle.

Seattle Mariners Recap

The Seattle Mariners come into this game looking to build on their 3-2 win over the Cardinals from Friday’s matchup to improve to 12-15 this season. After this series, the Mariners will head on the road for a series against the Minnesota Twins.

Mariners Pick Up Back-To-Back Wins

Entering Friday’s matchup, Brendan Donovan has 17 hits with 3 doubles, 3 home runs and 8 RBIs while Luke Raley has 5 home runs and 13 RBIs this season. Cole Young’s added 21 hits with 2 doubles, a triple, 2 home runs and 11 RBIs and Cal Raleigh has 20 hits with 4 doubles, 5 home runs and 14 RBIs as well this season. Randy Arozarena has 27 hits with 6 doubles, 2 home runs and 10 RBIs as well on the year. Josh Naylor also has 18 hits with 2 home runs and 10 RBIs as well on the year. Julio Rodriguez has also added 24 hits with 3 doubles, a home run and 8 RBIs.

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game looking to shake off their loss at the hands of Seattle on Friday to sit at 14-11 on the year. After this series, St. Louis will take on the Pittsburgh Pirates on the road.

Cardinals Drop Back-To-Back Games

Going into Friday, Jordan Walker leads the Cardinals with 26 hits, 4 doubles, 8 home runs and 16 RBIs while Alec Burleson has 25 hits with 6 doubles, 3 home runs and 17 RBIs. JJ Wetherholt has 19 hits with 3 home run and 11 RBIs while Ivan Herrera has 20 hits with 4 doubles and 12 RBIs. Nolan Gorman has 16 hits with 3 home runs and 15 RBIs this season.

Seattle Mariners @ St. Louis Cardinals Betting Trends: April 25, 2026

• Probable Starting Pitcher: Matthew Liberatore      Record this season: 0-1      ERA: 3.67
• Home Record: 0-1
• Last 5 against Mariners: 0-1

Why the St. Louis Cardinals will win

• The Mariners have lost each of their last seven games as road favorites after playing the previous day.
• The Cardinals have won each of their last four games as underdogs against AL West opponents following a home loss.
• The Mariners have failed to cover the run line in each of their last seven games as road favorites.
• The Cardinals have covered the run line in each of their last six games against American League opponents.
• The Mariners have trailed after 3 innings in three of their last four day games against National League opponents that held a winning record.
• The Cardinals have led after 5 innings in each of their last six Saturday games against AL West opponents that held a losing record.

• Probable Starting Pitcher: Bryan Woo      Record this season: 1-2      ERA: 2.25
• Road Record: 0-2
• Last 5 against Cardinals: 1-0

Why the Seattle Mariners will win

• The Mariners have won each of their last five games against the Cardinals.
• The Cardinals have lost six of their last seven day games against American League opponents following a loss.
• The Cardinals have failed to cover the run line in seven of their last eight day games against American League opponents following a loss.
• The Mariners have covered the run line in four of their last five games against the Cardinals.
• The Mariners have led after 3 innings in four of their last five games as road favorites against NL Central opponents.
• The Mariners have won the first inning in four of their last five games as road favorites against NL Central opponents.
• The Mariners have led after 5 innings in four of their last five day games.

Total Runs Facts

• Seven of the Mariners’ last eight games as road favorites have gone UNDER the total runs line.
• Seven of the Cardinals’ last eight games as underdogs against American League opponents have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Cardinals’ last nine Saturday day games.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Mariners’ last six games against National League opponents.

St. Louis Cardinals Player Prop Facts

• Masyn Winn has recorded at least one hit in each of his last nine appearances.
• Ramon Urias has hit a home run in four of his last eight home appearances against AL West opponents.
• Jordan Walker ranks T6th in the league in Home Runs (8) this season.

Seattle Mariners Player Prop Facts

• Cal Raleigh has hit at least one home run in five of the Mariners’ last six road games against NL Central opponents.
• Randy Arozarena has recorded at least one hit in each of his last 10 appearances against the Cardinals.

Matchup/League Facts

• The Cardinals rank 30th in the league for strikeouts this season (164).
• The Cardinals rank 29th in the league for hits this season (191).
• The Mariners rank 1st in the league for walks allowed this season (64).
• The Mariners rank 28th in the league for batting average this season (.223).

Seattle Mariners vs. St. Louis Cardinals Prediction

I’m on the Mariners in this one. I just think there’s another seismic starting pitching advantage that favors the Mariners and I think Bryan Woo has another strong start here. I’m always weary of backing Seattle against a left-handed starter, but I just think there’s too much going in the favor of Seattle here for me to think that St. Louis escapes with the W here. Give me Seattle.