Tigers vs Braves Prediction 9/21/25 MLB Picks Today
Atlanta Braves (72-83) vs. Detroit Tigers (85-70)
September 21, 2025 1:40 pm EDT
The Line: Detroit Tigers -123 / Atlanta Braves 101; Over/Under: 8.5
(Get latest betting odds)
In this article we will formulate a Tigers vs Braves prediction for this MLB game on Sunday, September 21st at Comerica Park in Detroit, Michigan. Let’s take a look at the prediction for this MLB matchup.
Detroit Tigers Betting Preview
The Detroit Tigers are 85-70 this year after they lost the first two games in this series by scores of 1-10 and 5-6. In their game two loss, Detroit led 5-3 in the seventh inning, but allowed the last three runs for the loss. The Tigers recorded nine hits in the game and they were led by Torkelson, who went 2-3 with one home run and three RBIs in the loss. Detroit started Montero, who allowed two hits and three earned runs over 3.0 innings, while Vest blew the save and picked up the loss.
Prior to this series, the Tigers lost all three against the Guardians and two out of three against the Marlins. Detroit has lost eight of their last nine games and they are first in the AL Central standings. The Detroit pitching staff has a 3.97 ERA with a 1.25 WHIP and a .241 opponent batting average, while the offense has scored 741 runs with a .247 batting average and a .316 on base percentage this season. Riley Greene has led Detroit with 34 home runs and 108 RBIs, while Spencer Torkelson has added 31 home runs and 78 RBIs this year. The projected starting pitcher for Detroit is Casey Mize, who is 14-5 with a 3.88 ERA and a 1.28 WHIP over 137.0 innings pitched this year.
Atlanta Braves Betting Preview
The Atlanta Braves are 72-83 this season after they won game two by a score of 6-5 on Saturday afternoon. Atlanta blew an early 3-1 lead, but they were able to rally in the top of the ninth to steal the victory. The Braves recorded seven hits in the game and they were led by Alvarez Jr, who went 3-4 with two home runs and three RBIs in the win. Atlanta started Wentz, who allowed six hits and two earned runs over 5.0 innings, while Dodd got the win and Iglesias picked up the save.
Prior to this series, the Braves swept the Nationals in four games, but lost two out of three against the Astros before that. Atlanta has won seven games in a row and they are currently fourth in the NL East standings. The Atlanta pitching staff has a 4.39 ERA with a 1.30 WHIP and a .246 opponent batting average, while their offense has scored 693 runs with a .245 batting average and a .319 on base percentage this year. Matt Olson has led Atlanta with 28 home runs and 93 RBIs, while Marcell Ozuna has added 20 home runs and 65 RBIs this year. The projected starting pitcher for Atlanta is Spencer Strider, who is 6-13 with a 4.64 ERA and a 1.36 WHIP over 114.1 innings pitched this season.
Why the Braves will beat the Tigers
- The Braves have won each of their last 10 road games against AL Central opponents that held a winning record.
- The Tigers have lost each of their last six games as home favorites.
- The Braves have covered the run line in each of their last 12 road games.
- The Tigers have failed to cover the run line in 12 of their last 13 games as home favorites against NL East opponents.
- The Braves have led after 5 innings in each of their last six day games against the Tigers.
- The Braves have led after 3 innings in each of their last four games against the Tigers.
Total Runs Facts
- Each of the Braves’ last seven day games after playing the previous day have gone OVER the total runs line.
- Six of the Tigers’ last seven games as favorites against NL East opponents have gone OVER the total runs line.
- The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Braves’ last four games at Comerica Park.
- The ‘Inning 1 OVER 0.5 runs’ market has hit in six of the Tigers’ last seven games as favorites against NL East opponents.
Detroit Tigers Player Prop Facts
- Casey Mize has recorded five or more strikeouts in four of his last five appearances in day games against teams that held a losing record.
- Casey Mize has recorded a win in six of his last seven home appearances against opponents that held a losing record.
- Spencer Torkelson has recorded at least one hit in each of his nine previous appearances in day games against NL East teams that held a losing record.
- Spencer Torkelson has hit a home run in four of his five previous appearances against the Braves.
Atlanta Braves Player Prop Facts
- Ronald Acuna Jr. has hit a home run in three of his last four appearances against the Tigers.
- Spencer Strider has recorded seven or more strikeouts in nine of his 10 previous appearances against AL opponents that held a winning record.
- Ozzie Albies has recorded at least one hit in each of the Braves’ last eight day games against opponents that held a winning record.
- Jarred Kelenic has recorded a Double in each of his last three appearances in day games against AL Central teams that held a winning record.
Tigers vs Braves Prediction
Detroit limps into this matchup trying to snap a losing streak and they are in danger of missing the playoffs with their recent play. The Tigers are 46-34 at home this year, while the Braves are 36-44 on the road. Atlanta has caught fire and they have won seven games in a row, while scoring at least five runs in five straight games. The Braves are starting Strider, who has allowed two earned runs or fewer in three of his last four starts. The Tigers are going with Mize, who has allowed 3+ earned runs in three of his last five outings. I know I have said this a lot recently, but we can’t back the Tigers with how they are playing. Take the Braves once again here.

