Tigers vs Guardians Prediction 5/24/25 MLB Picks Today

The Cleveland Guardians and the Detroit Tigers meet Saturday in MLB action from Comerica Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Tigers vs Guardians Prediction.

Starting Pitching Matchup

The Cleveland Guardians will start Luis Ortiz here and Ortiz is 2-5 with a 4.66 ERA and 56 strikeouts this season. This will be Ortiz’s first career start against the Tigers. The Detroit Tigers did not have a starting pitcher announced at the time that this article was posted.

Cleveland Guardians Recap

The Cleveland Guardians come into this game looking to build on their 3-1 win over the Tigers from Friday’s matchup to improve their record to 28-22 on the year. After this series, the Guardians will head home for an interleague series against the Los Angeles Dodgers.

Guardians Win Third In A Row

Steven Kwan leads the Guardians with 61 hits as part of a .314 batting average and 4 home runs, 11 doubles and 17 RBIs. Kyle Manzardo has 32 hits with 5 doubles, 2 triples, 10 home runs and a team-high 26 RBIs as well this year. Gabriel Arias has 8 doubles but also 46 strikeouts and Manzardo has 47 strikeouts so far this season. Arias has also added 4 home runs and 20 RBIs and Jose Ramirez has chipped in 9 home runs and 24 RBIs. Carlos Santana has also added 38 hits with 6 home runs and 26 RBIs as well this season.

Why the Cleveland Guardians will win

• The Guardians have won each of their last six games as underdogs following a road win.
• The Tigers have lost each of their last four games as favorites against AL Central opponents following a home loss.
• The Tigers have failed to cover the run line in each of their last nine games as favorites.
• The Guardians have covered the run line in each of their last 10 Saturday games as underdogs against AL Central opponents.

Cleveland Guardians Player Prop Facts

• Steven Kwan has hit a home run in each of his last three Saturday night appearances against AL Central teams that held a winning record.
• Steven Kwan has recorded at least one Single in each of the Guardians’ last 11 road games against AL opponents that held a winning record.
• Jose Ramirez has scored a run in each of the Guardians’ last six games against AL Central opponents.
• Carlos Santana has recorded at least one RBI in each of the Guardians’ last six games as underdogs.
• Jose Ramirez has recorded at least one hit in each of the Guardians’ last 16 games.

Detroit Tigers Recap

The Detroit Tigers come into this game looking to bounce back from their loss at the hands of the Guardians On Friday To Slip To 33-19 this season. After this series, the Tigers will welcome the San Francisco Giants to town for an interleague series.

Tigers Drop Back-To-Back Games

Spencer Torkelson has 43 hits along with a .244 batting average including a team-high 12 home runs, 13 doubles and 39 RBIs. Kerry Carpenter also has 10 home runs and 22 RBIs while Riley Greene has 54 hits with 10 doubles, 12 home runs and 34 RBIs but also has a team-high 61 strikeouts as well this season. Dillon Dingler has 4 home runs and 18 RBIs and Zack McKinstry’s added 9 doubles, 3 triples, 2 home runs and 17 RBIs of his own along with 44 hits as well this season. Javier Baez has added 42 hits and 8 doubles as well as 6 home runs and 29 RBIs this season.

Why the Detroit Tigers will win

• The Guardians have lost each of their last six Saturday night games against teams that held a winning record.
• The Tigers have won five of their last six night games at Comerica Park following a loss.
• The Tigers have covered the run line in 12 of their last 14 night games against AL Central opponents.
• The Guardians have failed to cover the run line in seven of their last eight Saturday night games.

Detroit Tigers Player Prop Facts

• Spencer Torkelson has hit a home run in each of the Tigers’ last five Saturday games as favorites.
• Zach McKinstry has recorded at least one Single in seven of his last eight home appearances against opponents that held a winning record.
• Spencer Torkelson has scored a run in each of the Tigers’ last six Saturday games as favorites.
• Casey Mize has recorded a win in each of his last four appearances.
• Spencer Torkelson has recorded at least one RBI in seven of the Tigers’ last eight Saturday games.
• Parker Meadows has recorded at least one hit in each of his last 13 appearances in night games.

Total Runs Facts

• Each of the Guardians’ last six night games after playing the previous day have gone UNDER the total runs line.
• Each of the Tigers’ last four games against American League opponents have gone UNDER the total runs line.

Tigers vs Guardians Prediction

I’m on the Tigers here. I get that the Tigers haven’t had the best start to this series, but I’m still not overly sold on Luis Ortiz as a consistent piece of this Guardians’ rotation. Furthermore, I think Detroit is still a team I want to back at home given their form at home up to this point, and I think that the Tigers get some revenge with a win in Saturday’s matchup. Give me the Tigers in this one.