Tigers vs Orioles Prediction 5/22/26 MLB Picks Today

In this article, we will formulate a Tigers vs Orioles Prediction for this MLB matchup on Friday, May 22^nd in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Baltimore Orioles Preview

The Baltimore Orioles have a 21-29 record this season and are sitting in the fifth place of the AL East. They have a 12-12 home record and are coming off a 5-3 loss against the Rays. They will face the Rays and the Blue Jays next.

The Orioles have a .233 batting average this season, .314 OBP and .386 Slugging percentage. Baltimore’s pitching staff has a 4.97 ERA and 1.46 WHIP. Taylor Ward is the team’s best hitter with a .257 batting average. Pete Alonso leads the team in RBI with 28, while Gunnar Henderson adds a team-high 10 home runs.

Chris Bassitt (R) is the projected starting pitcher for the Orioles, and he has a 3-3 record, 5.44 ERA and 1.70 WHIP.

Detroit Tigers Preview

The Detroit Tigers have a 20-31 record this season and are sitting in the fifth place of the AL Central. They have a 7-19 away record and are coming off a 3-1 loss against the Guardians. They will face the Angels and the White Sox next.

The Tigers have a .235 batting average this season, .318 OBP and .372 Slugging percentage. Detroit’s pitching staff has a 3.96 ERA and 1.28 WHIP. Riley Greene is the team’s best hitter with a .326 batting average. Dillon Dingler leads the team in RBI with 29, adding a team-high 9 home runs.

Jack Flaherty (R) is the projected starting pitcher for the Tigers, and he has a 0-5 record, 5.77 ERA and 1.60 WHIP.

Detroit Tigers @ Baltimore Orioles Betting Trends: May 22, 2026

• Probable Starting Pitcher: Chris Bassitt      Record this season: 3-3      ERA: 5.44
• Home Record: 2-1
• Last 5 against Tigers: 1-2

Why the Baltimore Orioles will win

• The Tigers have lost each of their last eight games following a home loss.
• The Orioles have won seven of their last eight games against AL Central opponents following a road loss.
• The Orioles have covered the run line in eight of their last nine night games against teams that held a losing record.
• The Tigers have failed to cover the run line in four of their last five games against AL East opponents.
• The Orioles have led after 3 innings in eight of their last 10 home games against AL Central opponents that held a losing record.
• The Tigers have trailed after 5 innings in four of their last five games against AL East opponents.

• Probable Starting Pitcher: Jack Flaherty      Record this season: 0-5      ERA: 5.77
• Road Record: 0-3
• Last 5 against Orioles: 0-1

Why the Detroit Tigers will win

• The road team has won each of the Tigers’ last six games.
• The Orioles have lost four of their last five games as favorites against American League opponents.
• The Tigers have covered the run line in seven of their last eight games at Oriole Park at Camden Yards against teams that held a losing record.
• The Orioles have failed to cover the run line in each of their last six games against American League opponents following a road loss.
• The Tigers have led after 3 innings in three of their last four road games.
• The Orioles have trailed after 5 innings in six of their last seven night games.

Total Runs Facts

• Each of the Orioles’ last six home games have gone UNDER the total runs line.
• Each of the Tigers’ last four games as underdogs have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of Chris Bassitt’s 10 previous appearances as a starter against the Tigers.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in 11 of Jack Flaherty’s last 12 road appearances as a starter.

Baltimore Orioles Player Prop Facts

• Adley Rutschman has hit a home run in three of his last four appearances after not playing the previous day.
• Chris Bassitt has recorded five or more strikeouts in each of his last 10 home appearances against AL opponents that held a losing record.
• Gunnar Henderson has recorded at least one hit in each of the Orioles’ last nine games against the Tigers.
• Chris Bassitt has recorded a win in each of his last three appearances against AL opponents.
• Taylor Ward ranks 3rd amongst qualified players for On Base Percentage (.415) this season.

Detroit Tigers Player Prop Facts

• Spencer Torkelson has hit a home run in two of the Tigers’ last three games as road underdogs against the Orioles.
• Jack Flaherty has recorded six or more strikeouts in each of his last five appearances in night games against AL East teams that held a losing record.
• Javier Baez has recorded at least one hit in each of his last 13 road appearances against AL East opponents.
• Riley Greene ranks 2nd amongst qualified players for Batting Average (.326) this season.

Matchup/League Facts

• The Orioles rank 28th in the league for strikeouts against this season (464).
• The Orioles rank 28th in the league for ERA this season (4.97).
• The Tigers rank 27th in the league for RBIs this season (185).
• The Tigers rank T27th in the league for steals this season (20).

Tigers vs Orioles Prediction

The Reds are 3-1 in their last 4 meetings against the Cardinals but are 1-2 in their last three visits in Cincinnati.

In this Tigers vs Orioles Prediction, the Orioles are coming as -130 home favorites. Both teams have been struggling as they are 1-5 and 1-9 in their last 6 and 10 games respectively and I don’t trust either pitcher in this matchup as they both have 5+ ERA and 1.60+ WHIP. Baltimore ranks 25^th in bullpen ERA and the total is set at just 8.5 runs when both pitchers have 4 earned runs across their last three starts combined. Take the over in this one.