Tigers vs Padres Prediction 4/21/25 MLB Picks Today

The San Diego Padres and the Detroit Tigers meet Monday in MLB action from Comerica Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Tigers vs Padres Prediction.

Starting Pitching Matchup

The San Diego Padres will start Randy Vasquez in this one, and Vasquez is 1-1 with a 1.74 ERA and 8 strikeouts this season. This will be Vasquez’s first career start against the Tigers. The Detroit Tigers will start Keider Montero here, and Montero is 0-1 with a 9.00 ERA and 8 strikeouts this season. This will be Montero’s second career start against the Padres.

San Diego Padres Recap

The San Diego Padres come into this game looking to build some momentum after picking up a 3-2 win over the Houston Astros last time out to improve to 16-6 on the year. After this series, the Padres will head home for a series with the Tampa Bay Rays.

Padres Salvage Win & Avoid Sweep Vs. Astros

Manny Machado has 25 hits, including a team-high 9 doubles and 6 stolen bases, while Fernando Tatis Jr. has 29 hits with a team-high 8 home runs and 16 RBIs, along with 7 stolen bases of his own this season. Luis Arraez has added 25 hits with 3 doubles, while Jackson Merrill’s added 14 hits with 3 home runs and 10 RBIs as well. Xander Bogaerts also has 8 doubles and 4 stolen bases this season.

Why the San Diego Padres will win

• The Padres have won each of their last nine Monday games.
• The Tigers have lost five of their last six games as home favorites after going to extra innings.
• The Tigers have failed to cover the run line in each of their last eight games as home favorites after going to extra innings.
• The Padres have covered the run line in seven of their last eight games as underdogs against AL Central opponents.

San Diego Padres Player Prop Facts

• Jose Iglesias has recorded at least one Single in 16 of his last 17 road appearances against opponents that held a winning record.
• Martin Maldonado has hit a home run in each of his last three appearances with his team as an underdog against AL Central opponents.
• Fernando Tatis Jr. has recorded at least one RBI in each of his last five road appearances against AL opponents that held a winning record.
• Jackson Merrill has recorded a Double in four of the Padres’ last five night games against AL Central opponents that held a winning record.
• Luis Arraez has recorded at least one hit in each of his last 15 road appearances against AL opponents that held a winning record.
• Connor Joe has scored a run in seven of his last eight appearances against the Tigers.

Detroit Tigers Recap

The Detroit Tigers come into this game looking to rebound from a 4-3 loss at the hands of the Kansas City Royals last time out to fall to 13-9 on the year. After this series, the Tigers will welcome the Baltimore Orioles to town.

Tigers Fail To Complete Sweep Vs. Royals

Spencer Torkelson leads the Tigers with 23 hits along with a .288 batting average, including a team-high 7 home runs, 7 doubles, and 21 RBIs. Kerry Carpenter also has 5 home runs and 11 RBIs, while Riley Greene has 19 hits with 4 doubles, 3 home runs, and 8 RBIs, but also has a team-high 31 strikeouts this season. Trey Sweeney also has 14 hits with 2 doubles, a triple, and a home run and 8 RBIs. Dillon Dingler has 2 home runs and 9 RBIs, and Zack McKinstry added a pair of triples, a home run, and 11 RBIs of his own along with 19 hits this season.

Why the Detroit Tigers will win

• The Tigers have won each of their last four night games following a loss.
• The Padres have lost five of their last six road games following a win.
• The Tigers have covered the run line each of their last six home games against teams that held a winning record.
• The Padres have failed to cover the run line in each of their last six road games against American League opponents following a win.

Detroit Tigers Player Prop Facts

• Manuel Margot has recorded at least one Single in each of his last seven appearances against NL opponents that held a winning record.
• Javier Baez has hit a home run in four of his last six appearances with his team as a home favorite against the Padres.
• Riley Greene has recorded at least one RBI in seven of the Tigers’ last eight games as home favorites against NL opponents.
• Riley Greene has recorded at least one Double in three of the Tigers’ last four home games against NL West opponents that held a winning record.
• Riley Greene has recorded at least one hit in each of his last 14 home appearances against NL West opponents.
• Javier Baez has scored at least one run in each of his last six appearances with his team as a favorite against the Padres.

Total Runs Facts

• Nine of the Tigers’ last 10 games after going to extra innings have gone UNDER the total runs line.
• Seven of the Padres’ last eight games after playing the previous day have gone UNDER the total runs line.

Tigers vs Padres Prediction

I’m on the over in this game. I just don’t trust Keider Montero in any way, shape, or form after his first start of the season, and he was inconsistent at the best of times last season. On the other side, I don’t think Randy Vasquez will be able to keep this low ERA going, as he’s issued 14 walks already this season. The Tigers have a rock-solid lineup from top to bottom that is producing early on this season. I think we have a high-scoring game here, so give me the over here.