Tigers vs Padres Prediction 4/22/25 MLB Picks Today

In this article, we will formulate a Tigers vs Padres prediction for this MLB game on Tuesday, April 22, at Comerica Park in Detroit, Michigan. Let’s take a look at the prediction for this MLB matchup.

San Diego Padres Betting Preview

The San Diego Padres (16-7, 4-6 Away) were on a five-game winning streak, but they lost four of the next six games, losing the series against the Houston Astros in the process. The Padres opened the series against the Tigers with a 6-4 loss last night. Randy Vasquez took the loss after allowing six runs on five hits with one strikeout and three walks in 2.0 innings. The bullpen didn’t allow a single run for the remainder of the game, but it was too late as Detroit had already done damage.

This season, the Padres average 4.41 runs per game (14th in the MLB) on a .276/.346/.424 slash line. Regarding pitching, the Padres’ staff has a 2.74 ERA (2nd) and 1.09 WHIP (3rd). Fernando Tatis Jr. leads the Padres with a .349 batting average, eight home runs, and 17 RBI this season.

The projected starting pitcher for the Padres is Nick Pivetta, who is 3-1 in four starts this season, with a 1.57 ERA and 0.83 WHIP in 23.0 innings.

Detroit Tigers Betting Preview

The Detroit Tigers (14-9, 9-2 Home) returned home from two series against the Twins and Brewers; they beat Minnesota and lost to Milwaukee. Back in Detroit, the Tigers beat the Royals 3-1 in the series and opened the current one against the Padres with a 6-4 victory. The hosts scored all of their runs in the first three innings; Gleyber Torres led the bunch with two RBI. Keider Montero pitched for 4.1 innings in a no-decision, allowing four runs (three earned) on five hits with three strikeouts and four walks. Brenan Hanifee was credited with the win.

This year, the Tigers average 4.55 runs per game (10th in the MLB) on a .246/.321/.387 triple-slash. When it comes to pitching, the Tigers’ staff has a 3.12 ERA (3rd) and 1.14 WHIP (5th). Spencer Torkelson leads the Tigers with a .286 batting average, seven home runs, and 21 RBI this season.

Jack Flaherty will take the mound for the Tigers on Tuesday. The 29-year-old right-hander has a 1-1 record in four starts this year with a 2.53 ERA and 1.08 WHIP in 21.1 innings.

Total Runs Facts

• Each of the Tigers’ last four games against NL West opponents have gone OVER the total runs line.
• Four of the Padres’ last five road games against AL Central opponents have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in eight of the Tigers’ last nine home games against NL West opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in four of the Padres’ last five games as road underdogs against AL Central opponents.

Matchup/League Facts

• The Tigers rank 3rd in the league for ERA this season (3.11).
• The Tigers rank 4th in the league for runs allowed this season (80).
• The Padres rank 1st in the league for strikeouts against this season (148).
• The Padres rank 2nd in the league for ERA this season (2.90).

Tigers vs Padres Prediction

The teams have traded victories in the past few seasons, as each recorded five in the previous ten H2H encounters. Both teams belong among the top 5 when it comes to pitching this season, so 10 runs in Game 1 was a bit surprising. I don’t expect another high-scoring affair on Tuesday, especially with Pivetta and Flaherty on the mound. Pivetta posted a 3.18 ERA in two starts against the Tigers last year, and I don’t think he will surrender more than two runs in a quality start here. Flaherty allowed a .298 BA in 47 at-bats against the Padres, which is not great, but he has been solid so far in the season and should pitch for at least five innings. I am going with Under.