Tigers vs White Sox Prediction 9/5/25 MLB Picks Today

In this article we will formulate a Tigers vs White Sox prediction for this MLB game on Friday, September 5th at Comerica Park in Detroit, Michigan. Let’s take a look at the prediction for this MLB matchup.

Detroit Tigers Betting Preview

The Detroit Tigers are 81-60 this season after they lost two out of three against the Mets by scores of 8-10, 5-12, and 6-2. In their game three win, Detroit led for just about the whole game and scored three runs in the seventh to seal the victory. The Tigers recorded 10 hits in the game and they were led by Carpenter, who went 1-3 with one home run and three RBIs in the win. Detroit started Mize, who allowed five hits and one earned run over 5.0 innings for the win, while Holton allowed one earned run in relief. 

Prior to that series, the Tigers won two out of three against the Royals, but lost all three against the Athletics before that. Detroit has lost seven of their last ten games and they are currently first in the AL Central standings. The Detroit pitching staff has a 3.89 ERA with a 1.24 WHIP and a .240 opponent batting average, while the offense has scored 680 runs with a .251 batting average and a .320 on base percentage this season. Riley Greene has led Detroit with 32 home runs and 103 RBIs, while Spencer Torkelson has added 28 home runs and 71 RBIs this year. The projected starting pitcher for Detroit is Jack Flaherty, who is 7-13 with a 4.74 ERA and a 1.29 WHIP over 142.1 innings pitched this season. 

Chicago White Sox Betting Preview

The Chicago White Sox are 53-88 this year after they won all four against Minnesota by scores of 6-5, 12-3, 4-3, and 11-8. In their game four win, Chicago trailed 7-4 in the sixth inning, but they scored the next seven runs to pull away with the victory. The White Sox recorded 15 hits and they committed one error in the game, while they were led by Teel, who went 3-5 with one home run and four RBIs in the win. Chicago started Ellard, who allowed two hits and zero earned runs over 1.1 innings, while Cannon allowed five earned runs in relief. 

Prior to that series, the White Sox lost three out of four against the Yankees and two out of three against the Royals. Chicago has won five games in a row, but they are still last in the AL Central standings. The Chicago pitching staff has a 4.23 ERA with a 1.37 WHIP and a .249 opponent batting average, while the offense has scored 569 runs with a .235 batting average and a .304 on base percentage this season. Lenyn Sosa has led Chicago with 19 home runs and 62 RBIs, while Andrew Benintendi has added 17 home runs and 55 RBIs this year. The projected starting pitcher for Chicago is Shane Smith, who is 4-7 with a 3.81 ERA and a 1.20 WHIP over 120.1 innings pitched this year. 

Why the White Sox will beat the Tigers

• The White Sox have won each of their last five games as underdogs.
• The Tigers have lost five of their last six games as favorites.
• The White Sox have covered the run line in each of their last 10 games following a win.
• The Tigers have failed to cover the run line each of their last four games against teams that held a losing record.
• The Tigers have lost the first inning in each of their last three home games against AL Central opponents that held a losing record.
• The White Sox have led after 5 innings in five of their last six games at Comerica Park against opponents that held a winning record.
• The White Sox have led after 3 innings in five of their last six games at Comerica Park against opponents that held a winning record.

Total Runs Facts

• Each of the Tigers’ last four games against American League opponents have gone UNDER the total runs line.
• Five of the White Sox’s last six games against AL Central opponents have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Tigers’ last six games as favorites against AL Central opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the White Sox’s last four night games at Comerica Park.

Matchup/League Facts

• The Tigers rank 30th in the league for steals this season (58).
• The Tigers rank 3rd in the league for triples this season (33).
• The White Sox rank 29th in the league for walks allowed this season (519).
• The White Sox rank 28th in the league for batting average this season (.234).

Tigers vs White Sox Prediction 

Chicago comes into this series in last place of the AL Central standings, but they have won five games in a row and their offense is hot right now. The White Sox are 23-46 on the road this year, while the Tigers are 45-27 at home. Detroit continues to be pretty inconsistent over the last two months and they are starting Flaherty, who has allowed at least five earned runs in three of his last five outings. Chicago is starting Smith, who has allowed two earned runs or fewer in four of his last five starts. I can’t back Detroit with Flaherty on the mound, so I will take a shot with the White Sox here.