Tigers vs White Sox Prediction 9/6/25 MLB Picks Today

The Chicago White Sox and Detroit Tigers meet Saturday in MLB action at Comerica Park. Here’s a Tigers vs White Sox Prediction. This article will include a Tigers vs White Sox Pick.

Chicago White Sox Betting Preview

The Chicago White Sox are 54-88 on the year and play the Rays, Guardians, and Orioles next. The Chicago White Sox are batting .236 on the season, have a .305 OBP, and a .379 slugging percentage. The Chicago White Sox pitching staff has a 4.23 ERA and a 1.37 WHIP. Lenyn Sosa leads the Chicago White Sox with 119 hits and 62 RBI, while Miguel Vargas and Chase Meidroth have combined for 201 hits and 73 RBI.

Martin Perez gets the ball for the Chicago White Sox, and he is 1-3 with a 2.16 ERA and 39 strikeouts this season. Perez is 2-6 with a 4.73 ERA and 74 strikeouts in his career against the Detroit Tigers.

Detroit Tigers Betting Preview

The Detroit Tigers are 81-61 on the year and play the Yankees, Marlins, and Guardians next. The Detroit Tigers are batting .251 on the season, have a .320 OBP, and a .422 slugging percentage. The Detroit Tigers pitching staff has a 3.91 ERA and a 1.24 WHIP. Riley Greene leads the Detroit Tigers with 142 hits and 103 RBI while Gleyber Torres and Spencer Torkelson have combined for 236 hits and 135 RBI.

Tarik Skubal gets the ball for the Detroit Tigers, and he is 12-4 with a 2.18 ERA and 216 strikeouts this season. Skubal is 7-2 with a 4.24 ERA and 64 strikeouts in his career against the Chicago White Sox.

The Chicago White Sox @ Detroit Tigers Betting Trends: September 6, 2025

• Probable Starting Pitcher: Tarik Skubal      Record this season: 12-4      ERA: 2.18
• Home Record: 8-1
• Last 5 against White Sox: 5-0

Why the Detroit Tigers will win

• The White Sox have lost each of their last 10 Saturday night games against teams that held a winning record.
• The Tigers have won each of their last six night games against the White Sox following a loss.
• The White Sox have failed to cover the run line each of their last 10 Saturday night games against teams that held a winning record.
• The Tigers have covered the run line in each of their last five Saturday night games against the White Sox.
• The Tigers have led after 5 innings in three of their last four night games against the White Sox at Comerica Park.
• The Tigers have led after 3 innings in four of their last five home games against opponents that held a losing record.

• Probable Starting Pitcher: Martin Perez      Record this season: 1-3      ERA: 2.16
• Road Record: 0-2
• Last 5 against Tigers: 0-1

Why the Chicago White Sox will win

• The White Sox have won each of their last six games as underdogs.
• The Tigers have lost six of their last seven games as favorites.
• The White Sox have covered the run line in each of their last 11 games following a win.
• The Tigers have failed to cover the run line in each of their last nine night games against American League opponents following a home loss.
• The Tigers have lost the first inning in each of their last four home games against AL Central opponents that held a losing record.

Total Runs Facts

• Twelve of the Tigers’ last 14 home games against American League opponents have gone OVER the total runs line.
• Six of the White Sox’s last seven games against AL Central opponents have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the White Sox’s last four games at Comerica Park.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in six of the Tigers’ last seven games as favorites against AL Central opponents.

Detroit Tigers Player Prop Facts

• Spencer Torkelson has recorded a Double in each of the Tigers’ last three home games against the White Sox.
• Spencer Torkelson has recorded at least one hit in each of the Tigers’ last 15 home games against AL Central opponents that held a losing record.
• Tarik Skubal has recorded a win in each of his last five appearances against the White Sox.
• Kerry Carpenter has hit a home run in four of the Tigers’ last six home games against AL Central opponents that held a losing record.
• Tarik Skubal ranks 2nd in the league for total Strikeouts (216) this season.

Chicago White Sox Player Prop Facts

• Andrew Benintendi has hit a home run in each of his last two appearances at Comerica Park against opponents that held a winning record.
• Martin Perez has recorded five or more strikeouts in four of his last five appearances in night games.
• Luis Robert has recorded at least one hit in 15 of his last 16 road appearances.

Matchup/League Facts

• The Tigers rank 30th in the league for steals this season (58).
• The Tigers rank 3rd in the league for triples this season (33).
• The White Sox rank 29th in the league for walks allowed this season (527).
• The White Sox rank 28th in the league for slugging percentage this season (.379).

Tigers vs White Sox Prediction

The Tigers are going to be favored at home as they’re the better team and have Skubal on the mound. Skubal is arguably the best pitcher in baseball with a 2.18 ERA and 0.87 WHIP, and he’s allowed 11 earned runs in his last 45.1 innings. However, the White Sox continue to play spoiler and have won six straight games. Also, as great as Skubal is, Perez has allowed 12 hits and 3 earned runs in his last 21.2 innings. Perez has allowed 2 earned runs in his last 18.1 innings. Perez is in great form and the White Sox are cashing tickets. I’ll take a shot in the dark with the potential massive payout.