Toronto Blue Jays vs Houston Astros Prediction 9/10/25 MLB Picks Today

The Houston Astros and the Toronto Blue Jays meet Wednesday in MLB action from Rogers Centre. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Houston Astros vs. Toronto Blue Jays prediction.

Starting Pitching Matchup

The Houston Astros will send out Jason Alexander for the start here and Alexander is 4-1 with a 4.68 ERA and 52 strikeouts this season. This will be Alexander’s first career start against the Blue Jays. Jose Berrios will get the nod for the Blue Jays here and is 9-5 with a 4.02 ERA and 131 strikeouts this season. In his last five starts against the Astros, Berrios is 3-1 with a 3.34 ERA and 13 strikeouts.

Houston Astros Recap

The Houston Astros come into this game looking to bounce back from a 4-3 loss at the hands of the Blue Jays in Tuesday’s matchup to sit at 78-67 on the year. After this series, the Astros will head on the road for a series against the Atlanta Braves.

Astros Drop 7 Of Last 10

Jose Altuve has 142 hits including 22 doubles, 24 home runs and 69 RBIs. Jeremy Pena also has 137 hits with 26 doubles, 15 homers and 54 RBIs with 20 stolen bases as well. Jake Meyers has 15 doubles as well and Christian Walker has 22 home runs and 76 RBIs but has also accrued a team-high 156 strikeouts so far this season. Altuve also has 9 stolen bases while Jake Meyers has 15 stolen bases this season. Isaac Paredes also has 19 home runs with 50 RBIs of his own and Cam Smith has contributed 8 homers and 49 RBIs. Yainer Diaz has also chipped in 120 hits with 18 home runs, 60 RBIs and 20 doubles.

Why the Houston Astros will win

• The Blue Jays have lost seven of their last eight games as favorites against American League opponents following a win.
• The Astros have won four of their last five games as underdogs against AL East opponents following a loss.
• The Astros have covered the run line in each of their last 10 games as underdogs against the Blue Jays following a loss.
• The Blue Jays have failed to cover the run line in each of their last nine games as favorites against the Astros following a win.

Houston Astros Player Prop Facts

• Yordan Alvarez has recorded a Double in each of the Astros’ last three games against AL East opponents.
• Jake Meyers has recorded at least one hit in each of his last 19 road appearances against AL opponents.
• Isaac Paredes has hit at least one home run in each of his last two road appearances against AL East opponents.
• Jeremy Pena ranks 6th amongst qualified players for Batting Average (.303) this season.

Toronto Blue Jays Recap

The Toronto Blue Jays come into this game looking to add on to their win over the Astros from Tuesday’s matchup to sit at 83-61 this season. After this series, the Blue Jays will take on the Baltimore Orioles in a series at home.

Blue Jays Looking To Create Distance In Division

George Springer has 127 hits and Bo Bichette has 181 hits with Springer adding 27 home runs, a triple, 21 doubles and 72 RBIs while Bichette has 44 doubles, 18 home runs and 93 RBIs. Andres Gimenez has added 60 hits with 8 doubles and 7 home runs and 27 RBIs this season along with 12 stolen bases. Vladimir Guerrero Jr. also has 23 homers, 33 doubles and 79 RBIs while Springer also has a .301 batting average and 91 strikeouts up to this point in the year. Addison Barger’s chipped in 27 doubles with 19 home runs and 65 RBIs and Ernie Clement’s added 28 doubles as part of his 132 hits this season.

Why the Toronto Blue Jays will win

• The Blue Jays have won 10 of their last 11 home games against AL West opponents.
• The Astros have lost each of their last four games at Rogers Centre against teams that held a winning record.
• The Blue Jays have covered the run line in 18 of their last 20 night games against American League opponents that held a winning record.
• The Astros have failed to cover the run line in 11 of their last 13 games after going to extra innings.

Toronto Blue Jays Player Prop Facts

• George Springer has hit at least one home run in each of the Blue Jays’ last three games as favorites.
• Jose Berrios has recorded four or more strikeouts in seven of his last eight appearances with the Blue Jays as home favorites against AL opponents.
• Bo Bichette has recorded a Double in each of his last five appearances against AL opponents that held a winning record.
• Bo Bichette has recorded at least one hit in each of his last 21 appearances with the Blue Jays as home favorites against AL opponents.
• Jose Berrios has recorded a win in each of his last four home appearances against the Astros.
• Vladimir Guerrero Jr. ranks 3rd amongst qualified players for On Base Percentage (.396) this season.

Total Runs Facts

• Each of the Astros’ last six games after going to extra innings have gone OVER the total runs line.
• Each of the Blue Jays’ last six night games after playing the previous day have gone OVER the total runs line.

Houston Astros vs. Toronto Blue Jays Prediction

I’m on the Blue Jays here. I get the case to be made for Houston, but the Blue Jays have a ton of momentum after walking off Houston on Tuesday and I think the Blue Jays can pick up another win here. The Astros have been struggling to put it all together and have been stumbling as of late and I think Toronto takes advantage of that here. Give me the Blue Jays in this one.