Twins vs Angels Prediction 9/10/25 MLB Picks Today

In this article, we will formulate a Twins vs Angels Prediction for this MLB game on Wednesday, September 10^th at the Angel Stadium in the third game of this series, with both teams being tied 1-1 wins. Let’s take a look at the prediction for this MLB matchup.

Los Angeles Angels Preview

The Los Angeles Angels have a 68-77 record this season and are sitting on the 4^th place of the AL West. The Angels have a 36-38 home record and 79-63 in over/under They are coming off a 12-2 home victory over the Twins, and are 2-4 in their last 6 games. Over is 4-1 in their last 5 games and are playing the Mariners and the Brewers next.

The Angels have a .229 batting average this season, .304 OBP and .401 Slugging percentage. LA’s pitching staff has a 4.82 ERA and 1.43 WHIP. Zach Neto leads the Angels with 127 hits, while Nolan Schanuel is the team’s best hitter with a .266 batting average. Taylor Ward leads the team with 96 RBI, while Jo Adell adds a team-high 35 home runs.

Jose Soriano (R) is the projected starting pitcher for the Angels, and he has a 10-10 record, 4.07 ERA and 1.37 WHIP.

Minnesota Twins Preview

The Minnesota Twins have a 64-81 record this season and are sitting on the 4^th place of the AL Central. The Twins have a 29-45 road record and are 69-67 in over/under. They are coming off a 2-12 road defeat by the Angels, that ended their two-game winning streak. Over is 9-3 in their last 12 games and are playing the Yankees and the Diamondbacks next.

The Twins have a .239 batting average this season, .312 OBP and .397 Slugging percentage. Minnesota’s pitching staff has a 4.60 ERA and 1.33 WHIP. Trevor Larnach leads the Twins with 117 hits, while Byron Buxton adds team-highs both in RBI, with 74, and in home runs, with 30. He is also the team’s best hitter with a .274 batting average.

Taj Bradley (R) is the projected starter for the Twins, and he has a 6-7 record, 4.92 ERA and 1.31 WHIP.

Minnesota Twins @ Los Angeles Angels Betting Trends: September 10, 2025

• Probable Starting Pitcher: Jose Soriano      Record this season: 10-10      ERA: 4.07
• Home Record: 2-8
• Last 5 against Twins: 0-2

Why the Los Angeles Angels will win

• The Twins have lost seven of their last eight day games against AL West opponents.
• The home team has won six of the last seven games between the Twins and Angels.
• The Twins have failed to cover the run line in seven of their last eight games against teams that held a losing record.
• The Angels have covered the run line each of their last five day games against American League opponents that held a losing record.
• The Twins have trailed after 3 innings in five of their last six road games against American League opponents that held a losing record.
• The Twins have trailed after 5 innings in five of their last six day games against American League opponents that held a losing record.

• Probable Starting Pitcher: Taj Bradley      Record this season: 6-7      ERA: 4.92
• Road Record: 2-4
• Last 5 against Angels: 0-0

Why the Minnesota Twins will win

• The underdogs have won eight of the Twins’ last nine games.
• The Angels have lost each of their last five games as favorites against American League opponents.
• The Twins have covered the run line in each of their last 10 games as road underdogs against AL West opponents following a loss.
• The Angels have failed to cover the run line in 12 of their last 13 games as home favorites against AL Central opponents following a win.
• The Angels have trailed after 3 innings in each of their last six Wednesday games as favorites.
• The Angels have lost the first inning in each of their last four day games against AL Central opponents that held a losing record.
• The Angels have trailed after 5 innings in 12 of their last 13 games as home favorites against AL Central opponents.

Total Runs Facts

• Each of the Angels’ last five games as favorites against American League opponents have gone OVER the total runs line.
• Each of the Twins’ last four games as underdogs against AL West opponents have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Twins’ last six games as underdogs against AL West opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Angels’ last seven Wednesday day games.

Los Angeles Angels Player Prop Facts

• Mike Trout has recorded at least one hit in each of his last 12 Wednesday day appearances.
• Jo Adell has hit a home run in four of his last five appearances against opponents that held a losing record.

Minnesota Twins Player Prop Facts

• Trevor Larnach has recorded a Double in three of his last four appearances in day games.
• Trevor Larnach has recorded at least one hit in each of his last eight appearances with the Twins as underdogs against AL West opponents.
• James Outman has hit a home run in each of his last two appearances with his team as a road underdog against AL West opponents.
• Byron Buxton ranks 4th amongst qualified players for Slugging Percentage (.563) this season.

Matchup/League Facts

• The Angels rank 30th in the league for strikeouts against this season (1429).
• The Angels rank 30th in the league for walks allowed this season (554).
• The Twins rank 5th in the league for walks allowed this season (413).
• The Twins rank 26th in the league for opponent batting average this season (.260).

Twins vs Angels Prediction

The Twins are 10-2 in their last 12 head-to-head meetings against the Angels, and are 4-1 in their last 5 visits in Los Angeles. Over is 8-3-1 in their last 12 meetings.

In this Twins vs Angels Prediction, the Angels are coming as -135 home favorites. I don’t trust either pitcher in this matchup, as they both have 4.00+ ERA, and Soriano for the Angels is coming off a horrendous start, where he gave up 8 runs against the Athletics. Soriano has also been terrible at home, with a 5.90 home ERA, while Bradley for the Twins has given up 4+ runs in three of his last four starts. Both bullpens are terrible, and both games in this series had 15 and 14 total runs. Take the over 9 in this one.