Twins vs Diamondbacks Prediction 9/14/25 MLB Picks Today

The Minnesota Twins and Arizona Diamondbacks meet on Saturday in MLB action from Target Field. Here’s a Diamondbacks vs Twins prediction. We will look at this from a betting perspective and determine the best D-backs and Twins pick.

Clutch Hitting Gets it Done for the Diamondbacks

Clutch hitting got it done for the Diamondbacks on Saturday night at Target Field. There were plenty of runners left in scoring position, but they finally picked up the hits in the 10th inning. Alek Thomas ended up hitting a home run and driving in two RBIs. Ryne Nelson got the start and he went six innings giving up four hits and zero runs. 

The Diamondbacks are averaging 4.95 runs while their pitching is giving up 4.82 runs per game. The offense is ranked 5th in the league, while the pitching is ranked 23rd. They are averaging 1.54 home runs per game which is 23rd in the league. Nabil Crismatt is getting the start for the Diamondbacks and he sits with a 2-0 record and an ERA of 3.34. Against the San Francisco 49ers he went four innings, giving up six hits and four runs. Two starts ago against the Texas Rangers, he went 6.1 innings, giving up seven hits and two runs. 

Why the Diamondbacks Will Beat the Twins

• The Twins have lost 11 of their last 12 games as home favorites after playing the previous day.
• The Diamondbacks have won each of their last six Sunday games as road underdogs against American League opponents.
• The Diamondbacks have covered the run line in each of their last 10 games as underdogs against American League opponents.
• The Twins have failed to cover the run line each of their last nine games at Target Field against teams that held a losing record.
• The Twins have trailed after 5 innings in five of their last six day games against opponents that held a losing record.

Twins Blew it in Extras

The Twins blew it in extra innings, and it continued a trend this year: another disappointing loss. The bullpen was actually pretty impressive until the 10th inning when they gave up three runs, and it all fell apart. Cole Sands went one inning, giving up two hits and two runs. After hitting three home runs on Friday, Kody Klemens continued the hot bat finishing with two hits and two runs driven in. 

The Twins are averaging 4.26 runs while their pitching is giving up 4.8 runs per game. The offense is ranked 23rd in the league while the pitching is ranked 24th. Byron Buxton has hit 31 home runs and driven in 76 RBIs. Getting the start for the Twins will be Bailey Ober and he sits with a 5-7 record and an ERA of 5.08. Against the Kansas City Royals, he went 5.1 innings giving up four hits and one run. He has been too inconsistent this season, but he looked good in the last start. 

Why the Twins Will Beat the Diamondbacks

• The Twins have won nine of their last 10 home games against the Diamondbacks.
• The Diamondbacks have lost five of their last six road games against AL Central opponents.
• The Twins have covered the run line in nine of their last 10 day games against NL West opponents.
• The Diamondbacks have failed to cover the run line in four of their last five day games against AL Central opponents.
• The Diamondbacks have trailed after 5 innings in four of their last five games as underdogs against AL Central opponents.

Diamondbacks vs Twins Prediction

The Twins were able to pick up a win in Ober’s last start, but they aren’t going to be so fortunate here. Crismatt sits with an ERA of 3.34 and in his last start he gave up only two runs. It feels like most starts, Ober gives up four or five runs, and he’s going to be lit up in a huge way here. The Diamondbacks’ offense has been inconsistent at best, but in this game, they are going to get the job done. Don’t forget about the Twins bullpen, they have blown plenty of games the last few months. Back the Diamondbacks.