Twins vs Guardians Prediction 9/20/25 MLB Picks Today

The Cleveland Guardians and Minnesota Twins meet Saturday in a MLB doubleheader at Target Field. Here’s a Twins vs Guardians Prediction. This article will include a Twins vs Guardians Pick.

Cleveland Guardians Betting Preview

The Cleveland Guardians are 82-71 on the year and play the Tigers and Rangers next. The Cleveland Guardians are batting .240 on the season, have a .313 OBP, and a .399 slugging percentage. The Cleveland Guardians pitching staff has a 4.66 ERA and a 1.34 WHIP. Steven Kwan leads the Cleveland Guardians with 161 hits and 50 RBI, while Jose Ramirez and Kyle Manzardo have combined for 262 hits and 137 RBI.

Logan Allen and Slade Cecconi get the ball for the Cleveland Guardians.

Minnesota Twins Betting Preview

The Minnesota Twins are 66-87 on the year and play the Rangers and Phillies next. The Minnesota Twins are batting .240 on the season, have a .313 OBP, and a .399 slugging percentage. The Minnesota Twins pitching staff has a 4.66 ERA and a 1.34 WHIP. Byron Buxton leads the Minnesota Twins with 122 hits and 76 RBI while Trevor Larnach and Brooks Lee have combined for 232 hits and 122 RBI.

Joe Ryan and Bailey Ober get the ball for the Minnesota Twins.

Cleveland Guardians @ Minnesota Twins Betting Trends: September 20, 2025: Game 1

• Probable Starting Pitcher: Joe Ryan      Record this season: 13-8      ERA: 3.35
• Home Record: 7-4
• Last 5 against Guardians: 0-3

Why the Minnesota Twins will win

• The Twins have won each of their last five day games against teams that held a winning record.
• The Guardians have lost 12 of their last 14 games on the first leg of a doubleheader.
• The Guardians have failed to cover the run line each of their last seven day games against AL Central opponents that held a losing record.
• The Twins have covered the run line each of their last six day games against teams that held a winning record.
• The Twins have led after 3 innings in each of their last four day games against the Guardians at Target Field.
• The Twins have led after 5 innings in each of their last five day games against opponents that held a winning record.
• The Twins have won the first inning in three of their last four day games against AL Central opponents that held a winning record.

• Probable Starting Pitcher: Slade Cecconi      Record this season: 6-6      ERA: 4.39
• Road Record: 4-3
• Last 5 against Twins: –

Why the Cleveland Guardians will win

• The Twins have lost each of their last nine games against the Guardians following a home loss.
• The Guardians have won each of their last eight games.
• The Twins have failed to cover the run line in each of their last nine home games against the Guardians following a home loss.
• The Guardians have covered the run line in each of their last seven road games.
• The Twins have trailed after 5 innings in five of their last six games.
• The Twins have lost the first inning in each of their last three games.
• The Twins have trailed after 3 innings in four of their last five games against AL Central opponents.

Total Runs Facts

• Eight of the Guardians’ last nine games after playing the previous day have gone UNDER the total runs line.
• Nine of the Twins’ last 11 home games on the first leg of a doubleheader have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Twins’ last five day games at Target Field.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in six of the Guardians’ last seven road games.

Minnesota Twins Player Prop Facts

• Joe Ryan has recorded seven or more strikeouts in seven of his last eight appearances against opponents that held a winning record.
• Joe Ryan has recorded a win in four of his last five home appearances against AL Central opponents.
• Trevor Larnach has recorded a Double in four of his last five appearances in day games.
• Trevor Larnach has recorded at least one hit in each of his last nine appearances in day games against AL teams that held a winning record.
• Byron Buxton has hit a home run in four of his last five appearances in day games against teams that held a winning record.

Cleveland Guardians Player Prop Facts

• Jose Ramirez has recorded a Double in five of the Guardians’ last six games at Target Field against opponents that held a losing record.
• Lane Thomas has recorded at least one hit in each of his 12 previous road appearances against AL Central opponents that held a losing record.
• Jose Ramirez has hit a home run in two of the Guardians’ last three games against the Twins.

Matchup/League Facts

• The Twins rank 27th in the league for opponent batting average this season (.260).
• The Twins rank 26th in the league for ERA this season (4.66).
• The Guardians rank 30th in the league for hits this season (1134).
• The Guardians rank 30th in the league for batting average this season (.226).

Twins vs Guardians Prediction

Game 1 Prediction: Allen has been hit or miss this season, especially on the road, where he has a 5.01 ERA and .267 allowed batting average. It doesn’t matter, as the Guardians have lost one game since September 5. The Twins have underachieved all year and while Ryan has been strong this year, he’s allowed 8 hits and 7 runs in his last 6 innings. Ryan has allowed 13 runs in his last 18 innings. It looks like Ryan may be running out of gas. Either way, the Guardians are as hot as fish grease. Give me the Guardians.

Game 2 Prediction: The Twins have lost 13 of the last 15 games Ober has pitched. That’s really all that needs to be said. The Guardians are rolling and fighting for a playoff spot, and I doubt it gets tripped up by a pitcher who can’t lead his team to a victory. Give me the Guardians for a sweep of the doubleheader on Saturday.