Twins vs Mets Prediction 4/22/26 MLB Picks Today

In this article, we will formulate a Twins vs Mets Prediction for this MLB matchup on Wednesday, April 22^nd in the second game of this series. Let’s take a look at the prediction for this MLB matchup.

New York Mets Preview

The New York Mets have a 7-16 record this season and are sitting in the fifth place of the NL East. They have a 3-7 home record and are coming off a 3-5 home loss against the Twins. They dropped their previous three games on the road to the Cubs by scores of 1-2, 2-4, and 4-12.

The Mets have a .222 batting average this season, .285 OBP and .332 Slugging percentage. New York’s pitching staff has a 4.10 ERA and 1.27 WHIP. Francisco Alvarez is the team’s best hitter with a .250 batting average, also adding a team‑high 4 home runs. Bo Bichette leads the team in RBI with 9.

Clay Holmes (R) is the projected starting pitcher for the Mets, and he has a 2-2 record, 1.96 ERA and 1.09 WHIP.

Minnesota Twins Preview

The Minnesota Twins have a 12-11 record this season and are sitting in the second place of the AL Central. They have a 5-5 away record and are coming off a 5-3 road win against the Mets. They dropped their previous three games at home against the Reds by scores of 4-7, 4-5, and 1-2.

The Twins have a .228 batting average this season, .329 OBP and .378 Slugging percentage. Minnesota’s pitching staff has a 4.01 ERA and 1.34 WHIP. Victor Caratini is the team’s best hitter with a .258 batting average. Josh Bell leads the team in RBI with 15, and Byron Buxton adds a team‑high 4 home runs.

Connor Prielipp (L) is the projected starting pitcher for the Twins and he will make his MLB debut. He has appeared in four games for St. Paul and started three. Over 15 ⅔ innings, he has allowed four runs, striking out 22 and upping his strikeout per nine to 12.6 strikeouts.

Minnesota Twins @ New York Mets Betting Trends: April 22, 2026

• Probable Starting Pitcher: Clay Holmes      Record this season: 2-2      ERA: 1.96
• Home Record: 0-1
• Last 5 against Twins: 1-1

Why the New York Mets will win

• The Twins have lost each of their last nine night games against NL East opponents following a win.
• The Mets have won each of their last eight Wednesday night home games against American League opponents.
• The Twins have failed to cover the run line in each of their last eight night games against NL East opponents following a win.
• The favorites have covered the run line in four of the Twins’ last five games at Citi Field.
• The Mets have led after 5 innings in each of their last four night games against the Twins at Citi Field.
• The Twins have trailed after 3 innings in five of their last six road games against NL East opponents that held a losing record.

• Probable Starting Pitcher: Connor Prielipp      Record this season: –      ERA: –
• Road Record: –
• Last 5 against Mets: –

Why the Minnesota Twins will win

• The Mets have lost each of their last eight games as home favorites after playing the previous day.
• The underdogs have won each of the Mets’ last six games at Citi Field.
• The Mets have failed to cover the run line in each of their last nine night games against American League opponents following a home loss.
• The underdogs have covered the run line in each of the Mets’ last eight games at Citi Field.
• The Twins have won the first inning in four of their last five night games against opponents that held a losing record.
• The Twins have led after 3 innings in four of their last five road games.
• The Mets have trailed after 5 innings in three of their last four home games.

Total Runs Facts

• Seven of the Twins’ last eight games after playing the previous day have gone OVER the total runs line.
• Six of the Mets’ last seven night games against AL Central opponents have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in six of the Twins’ last seven games as underdogs.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in six of the last seven night games between the Twins and Mets at Citi Field.

New York Mets Player Prop Facts

• Juan Soto has hit a home run in three of his last four appearances against AL Central opponents.
• Bo Bichette has recorded at least one hit in each of his last 16 appearances with his team as a favorite against AL Central opponents.

Minnesota Twins Player Prop Facts

• Byron Buxton has hit at least one home run in each of the Twins’ last three night games against opponents that held a losing record.
• Victor Caratini has recorded at least one hit in each of his last seven appearances with his team as a road underdog against NL East opponents.

Matchup/League Facts

• The Mets rank 30th in the league for runs scored this season (75).
• The Mets rank 30th in the league for RBIs this season (71).
• The Twins rank T28th in the league for doubles this season (28).
• The Twins rank 3rd in the league for home runs allowed this season (14).

Twins vs Mets Prediction

The Twins are 4-1 in their last 5 meetings against the Mets but both teams are tied 2-2 in their last four meetings in New York.

In this Twins vs Mets Prediction, the Mets are coming as -160 home favorites. The Mets woes continue as they have lost their 12^th consecutive game, even though they had the pitching advantage on paper yesterday. The Mets have the worst offense in baseball, scoring just 3.2 runs per game, while the Twins’ offense has been consistent, with 4+ runs in nine of their last ten games. At this point the Mets are insta-fade, especially as -160 favorites, so I will take a stab once again with the Twins and the nice plus money price.