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Twins vs Red Sox Prediction 4/15/26 MLB Picks Today

Boston Red Sox (6-11) vs. Minnesota Twins (11-7)
April 15, 2026 1:40 pm EDT
The Line: Minnesota Twins 119 / Boston Red Sox -143; Over/Under: 8
(Get latest betting odds)

In this article we will formulate a Twins vs Red Sox prediction for this MLB game on Wednesday, April 15th at Target Field in Minneapolis, Minnesota. Let’s take a look at the prediction for this MLB matchup. 

Minnesota Twins Betting Preview

The Minnesota Twins are 11-7 this season after they won the first two games in this series by scores of 13-6 and 6-0. In game two, Minnesota scored a run in the first inning and never looked back in the shutout win. The Twins recorded 10 hits in the game and they were led by Buxton and Larnach, who both had two RBIs. Abel allowed four hits and zero earned runs over 7.0 innings for the win, while Rogers and Sands completed the shutout in relief. Prior to this series, Minnesota won two out of three against the Blue Jays and all four against the Tigers. 

This season, Minnesota has a 4.04 ERA with a 1.38 WHIP and a .254 opponent batting average, while they have scored 98 runs with a .235 batting average and a .336 on base percentage. Josh Bell has led the Twins with three home runs and 14 RBIs, while Tristan Gray has added two home runs and 11 RBIs. The projected starting pitcher for Minnesota is Simeon Woods Richardson, who is 0-2 with a 4.60 ERA and a 1.28 WHIP over 15.2 innings pitched this season. 

Boston Red Sox Betting Preview

The Boston Red Sox are 6-11 this year after they lost game two in this series by a score of 6-0 on Tuesday night. Boston allowed five runs in the first four innings and another in the sixth in the ugly loss. The Red Sox recorded six hits in the game and they were led by Anthony and Yoshida, who both had two hits. Gray allowed nine hits and five earned runs over 4.0 innings for the loss, while Anderson allowed one earned run in relief. Prior to this series, Boston won two out of three against the Cardinals and two out of three against the Brewers. 

This season, Boston has a 4.52 ERA with a 1.36 WHIP and a .244 opponent batting average, while they have scored 68 runs with a .231 batting average and a .315 on base percentage. Wilson Contreras has led the Red Sox with three home runs and 11 RBIs, while Trevor Story has added one home run and 12 RBIs. The projected starting pitcher for Boston is Connelly Early, who is 0-0 with a 2.63 ERA and a 1.54 WHIP over 13.2 innings pitched this year. 

Why the Minnesota Twins will win

  • The Twins have won seven of their last eight games as underdogs.
  • The Red Sox have lost each of their last seven games against American League opponents.
  • The Red Sox have failed to cover the run line in each of their last seven games as favorites against American League opponents.
  • The Twins have covered the run line in each of their last six home games.
  • The Twins have led after 3 innings in each of their last six games against AL East opponents.
  • The Red Sox have lost the first inning in seven of their last eight games as road favorites against American League opponents.
  • The Red Sox have trailed after 5 innings in each of their last eight games against American League opponents.

Why the Boston Red Sox will win

  • The Twins have lost six of their last seven games against AL East opponents following a home win.
  • The Red Sox have won four of their last five day games against AL Central opponents.
  • The Red Sox have covered the run line in each of their last six Wednesday games at Target Field.
  • The Twins have failed to cover the run line in each of their last five Wednesday day home games.
  • The Twins have lost the first inning in three of their last four day games against AL East opponents.
  • The Red Sox have led after 5 innings in four of their last five day games against the Twins.
  • The Red Sox have led after 3 innings in each of their last four day games against the Twins.

Total Runs Facts

  • Six of the Red Sox’s last seven road games after playing the previous day have gone OVER the total runs line.
  • Four of the Twins’ last five games have gone OVER the total runs line.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Red Sox’s last 11 games as road favorites against American League opponents.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Twins’ last five games.

Minnesota Twins Player Prop Facts

  • Byron Buxton has recorded at least one hit in each of his last 11 appearances against the Red Sox.
  • Byron Buxton has hit at least one home run in four of his last five home appearances against the Red Sox.

Boston Red Sox Player Prop Facts

  • Roman Anthony has recorded at least one hit in each of his last nine appearances in day games against AL teams that held a winning record.
  • Jarren Duran has hit a home run in three of the Red Sox’s last four games against the Twins.

Twins vs Red Sox Prediction 

Minnesota comes into this matchup on a four game winning streak and they have scored 6+ runs in all four of those wins. The Twins are 7-2 at home this year, while the Red Sox are 3-8 on the road. Boston has split their last four games and they have scored 6+ runs in three of those four. The Red Sox are starting Early, who has allowed four earned runs and 13 hits over 13.2 innings. The Twins are going with Woods Richardson, who allowed five earned runs in his last start. I am going to take Boston with Early on the mound, but this Minnesota offense is definitely a concern. 

David Racey's Free Pick: Red Sox ML

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David Racey

David started writing about sports in 2015, but sports has been his passion for as long as he can remember. David spends most of his free time watching pretty much anything sports related from Baseball to Tennis and everything in between. David likes to analyze statistics and recent results to form an unbiased opinion on whatever game he is breaking down. Follow David on Twitter at @itsyerboi41

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