Twins vs White Sox Prediction 4/22/25 MLB Picks Today

In this article, we will formulate a Twins vs White Sox prediction for this MLB game on Tuesday, April 22nd at Target Field in Minneapolis, Minnesota. Let’s take a look at the prediction for this MLB matchup. 

Minnesota Twins Betting Preview

The Minnesota Twins are 7-15 this year after they were swept by the Braves by scores of 4-6, 3-4, and 2-6. In their game three loss, Minnesota allowed the first five runs in the game and only managed to score two runs in the loss. The Twins recorded five hits in the game, and they were led by Buxton, who went 2-5 with one home run and one RBI in the loss. Minnesota started Ryan, who allowed eight hits and six earned runs over 5.0 innings, while Varland, Duran, and Coulombe pitched three scoreless innings in relief. 

Prior to that series, the Twins won two out of three against the Mets, but did lose two out of three against the Tigers before that. Minnesota has lost four of its last six games, and they are currently fourth in the AL Central standings. The Minnesota pitching staff has a 4.03 ERA with a 1.23 WHIP and a .243 opponent batting average, while their offense has scored 75 runs with a .211 batting average and a .282 on-base percentage this season. Harrison Bader has led Minnesota with three home runs and 12 RBIs, while Byron Buxton has added four home runs and 10 RBIs this year. The projected starting pitcher for Minnesota is Bailey Ober, who is 1-1 with a 6.16 ERA and a 1.42 WHIP over 19.0 innings pitched this season. 

Chicago White Sox Betting Preview

The Chicago White Sox are 5-17 this season after they lost three out of four against Boston by scores of 3-10, 3-4, 8-4, and 2-4. In their loss on Monday, the White Sox jumped out to a 1-0 lead in the first inning, but they only scored one run in the final eight innings in the loss. The White Sox recorded five hits in the game, and they were led by Benintendi, who went 2-3 with one home run and one RBI in the loss. Chicago started Cannon, who allowed six hits and four earned runs over 6.0 innings in the loss, while Gilbert and Murfee pitched the final two innings in the game. 

Prior to that series, the White Sox lost all three against the Athletics, but did win two out of three against the Red Sox before that. Chicago has lost seven of their last eight games, and they are currently last in the AL Central standings. The Chicago pitching staff has a 4.34 ERA with a 1.35 WHIP and a .237 opponent batting average, while the offense has scored 70 runs with a .196 batting average and a .270 on-base percentage this season. Brooks Baldwin has led Chicago with two home runs and 10 RBIs, while Andrew Vaughn has added three home runs and 10 RBIs this year. The projected starting pitcher for Chicago is Davis Martin, who is 1-2 with a 4.84 ERA and a 1.48 WHIP over 22.1 innings pitched this season. 

Why the Twins will beat the White Sox

• The White Sox have lost each of their last 15 night games against AL Central opponents.
• The Twins have won each of their last 12 home games against the White Sox.
• The White Sox have failed to cover the run line in 11 of their last 12 games at Target Field against teams that held a losing record.
• The Twins have covered the run line in seven of their last eight home games against AL Central opponents that held a losing record.
• The White Sox have lost the first inning in five of their last six games against AL Central opponents that held a losing record.
• The White Sox have trailed after 5 innings in each of their last six road games.
• The Twins have led after 3 innings in nine of their last 10 night games against the White Sox at Target Field.

Total Runs Facts

• Each of the Twins’ last four games as favorites have gone UNDER the total runs line.
• Four of the White Sox’s last five night games against AL Central opponents have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in six of the White Sox’s last seven games as underdogs against AL Central opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the Twins’ last six home games against American League opponents.

Minnesota Twins Player Prop Facts

• Carlos Correa has recorded a Double in three of his last four appearances with the Twins as favorites against AL Central opponents.
• Byron Buxton has hit a home run in each of his last three home appearances against the White Sox after not playing the previous day.
• Bailey Ober has recorded seven or more strikeouts in each of his last four appearances with the Twins as favorites against AL Central opponents.
• Bailey Ober has recorded a win in five of his last six appearances in night games against AL teams that held a losing record.
• Byron Buxton has recorded at least one RBI in each of his last seven home appearances against the White Sox after not playing the previous day.
• Ryan Jeffers has recorded at least one Single in each of his last eight appearances against the White Sox after not playing the previous day.
• Byron Buxton has scored at least one run in each of his last six appearances against the White Sox after not playing the previous day.
• Willi Castro has recorded at least one hit in each of the Twins’ last 11 games as home favorites against AL Central opponents.

Chicago White Sox Player Prop Facts

• Andrew Benintendi has hit at least one home run in three of his last seven road appearances against opponents that held a losing record.
• Andrew Benintendi has recorded at least one Single in each of his last four appearances against AL Central opponents that held a losing record.
• Andrew Benintendi has recorded at least one hit in each of his last seven appearances against AL Central opponents that held a losing record.
• Mike Tauchman has recorded at least one RBI in each of his three previous road appearances against the Twins.
• Mike Tauchman has scored at least one run in five of his last six appearances against the Twins.
• Luis Robert ranks T6th in the league in Steals (7) this season.

Matchup/League Facts

• The Twins rank 2nd in the league for walks allowed this season (56).
• The Twins rank 27th in the league for hits this season (153).
• The White Sox rank 30th in the league for hits this season (139).
• The White Sox rank 30th in the league for doubles this season (24).

Twins vs White Sox Prediction 

Both of these teams come into this series towards the bottom of the AL standings, but Minnesota will be at home, where they are 4-5 this year. Chicago is just 1-9 on the road this season, and they have lost 15 of their last 18 games overall. Both of these pitchers have elevated WHIPs on the season, but Ober has allowed three earned runs or fewer in his last three starts. Minnesota is the better team in this matchup, and they should have a nice bounce-back after getting swept. Take the Twins -1.5 in this game.