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Twins vs White Sox Prediction 9/4/25 MLB Picks Today

Chicago White Sox (52-88) vs. Minnesota Twins (62-77)
September 4, 2025 7:40 pm EDT
The Line: Minnesota Twins -158 / Chicago White Sox 129; Over/Under: 8.5
(Get latest betting odds)

The Chicago White Sox and Minnesota Twins meet Thursday in MLB action at Target Field. Here’s a Twins vs White Sox Prediction. This article will include a Twins vs White Sox Pick.

Chicago White Sox Betting Preview

The Chicago White Sox are 52-88 on the year and play the Tigers, Rays, and Guardians next. The Chicago White Sox are batting .234 on the season, have a .303 OBP, and a .376 slugging percentage. The Chicago White Sox pitching staff has a 4.20 ERA and a 1.37 WHIP. Lenyn Sosa leads the Chicago White Sox with 119 hits and 62 RBI, while Miguel Vargas and Andrew Benintendi have combined for 198 hits and 106 RBI.

Fraser Ellard gets the ball for the Chicago White Sox, and he is 0-2 with a 4.82 ERA and 13 strikeouts this season. Ellard is 0-0 with a 0.00 ERA and 3 strikeouts in his career against the Minnesota Twins.

Minnesota Twins Betting Preview

The Minnesota Twins are 62-77 on the year and play the Royals, Angels, and Diamondbacks next. The Minnesota Twins are batting .238 on the season, have a .311 OBP, and a .397 slugging percentage. The Minnesota Twins pitching staff has a 4.51 ERA and a 1.32 WHIP. Byron Buxton leads the Minnesota Twins with 112 hits and 72 RBI, while Trevor Larnach and Brooks Lee have combined for 213 hits and 112 RBI.

Taj Bradley gets the ball for the Minnesota Twins, and he is 6-7 with a 4.82 ERA and 102 strikeouts this season. Bradley is 0-1 with a 14.85 ERA and 1 strikeout in his career against the Chicago White Sox.

Twins vs White Sox Prediction

I’ve said it time and time again, I’m not in the business of backing the White Sox, a team I’ve blindly faded for much of the last three years. However, the White Sox are winning games here and there lately, and we keep getting them at plus money. Regardless of what you think of the White Sox, laying juice with the Twins is even worse. The Twins aren’t a good team, the losses keep piling up, and yet here they are as a favorite again. It makes no sense. As I’ve done twice this series already, give me the White Sox and the more favorable price as a fade of the Twins more than anything.

Randy Chambers's Free Pick: Chicago White Sox 129

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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