Twins vs Yankees Prediction 9/16/25 MLB Picks Today

The New York Yankees and Minnesota Twins meet Tuesday in MLB action at Target Field. Here’s a Twins vs Yankees Prediction. This article will include a Twins vs Yankees Pick.

New York Yankees Betting Preview

The New York Yankees are 83-67 on the year and play the Orioles, White Sox, and Orioles next. The New York Yankees are batting .248 on the season, have a .329 OBP, and a .452 slugging percentage. The New York Yankees pitching staff has a 4.02 ERA and a 1.27 WHIP. Aaron Judge leads the New York Yankees with 163 hits and 102 RBI, while Cody Bellinger and Paul Goldschmidt have combined for 276 hits and 136 RBI.

Cam Schlittler gets the ball for the New York Yankees, and he is 3-3 with a 3.05 ERA and 63 strikeouts this season. This will be Schlittler’s second career game against the Minnesota Twins.

Minnesota Twins Betting Preview

The Minnesota Twins are 66-84 on the year and play the Guardians, Rangers, and Phillies next. The Minnesota Twins are batting .240 on the season, have a .313 OBP, and a .400 slugging percentage. The Minnesota Twins pitching staff has a 4.58 ERA and a 1.33 WHIP. Byron Buxton leads the Minnesota Twins with 120 hits and 76 RBI while Trevor Larnach and Brooks Lee have combined for 227 hits and 118 RBI.

Zebby Matthews gets the ball for the Minnesota Twins, and he is 4-5 with a 5.06 ERA and 80 strikeouts this season. This will be Matthews’ second career game against the New York Yankees.

New York Yankees @ Minnesota Twins Betting Trends: September 16, 2025

• Probable Starting Pitcher: Zebby Matthews      Record this season: 4-5      ERA: 5.06
• Home Record: 2-1
• Last 5 against Yankees: 0-1

Why the Minnesota Twins will win

• The underdogs have won seven of the Twins’ last eight games at Target Field.
• The Yankees have lost four of their last five games as favorites against AL Central opponents.
• The underdogs have covered the run line in each of the Twins’ last 14 games.
• The Yankees have failed to cover the run line in four of their last five games against AL Central opponents.
• The Twins have led after 3 innings in four of their last five home games against opponents that held a winning record.
• The Twins have led after 5 innings in each of their last six home games against opponents that held a winning record.

• Probable Starting Pitcher: Cam Schlittler      Record this season: 3-3      ERA: 3.05
• Road Record: 0-1
• Last 5 against Twins: 0-0

Why the New York Yankees will win

• The Twins have lost each of their last nine games following a home win.
• The Yankees have won eight of their last nine night games against teams that held a losing record.
• The Twins have failed to cover the run line in each of their last nine games following a home win.
• The Yankees have covered the run line in each of their last nine Tuesday games as road favorites against AL Central opponents.
• The Yankees have won the first inning in three of their last four games as favorites.
• The Yankees have led after 3 innings in 10 of their last 11 games against the Twins.
• The Yankees have led after 5 innings in six of their last seven games as road favorites.

Total Runs Facts

• Each of the last four games between the Yankees and Twins at Target Field have gone UNDER the total runs line.
• Each of the Yankees’ last three games as favorites have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the Twins’ last eight home games against AL East opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in four of the Yankees’ last five games.

Minnesota Twins Player Prop Facts

• Trevor Larnach has recorded at least one hit in each of the Twins’ last nine home games against AL opponents.
• James Outman has hit a home run in each of his last two appearances with the Twins as underdogs.
• Trevor Larnach has recorded a Double in each of the Twins’ last three games as home underdogs against AL opponents.
• Byron Buxton ranks 5th amongst qualified players for Slugging Percentage (.553) this season.

New York Yankees Player Prop Facts

• Aaron Judge has hit at least one home run in three of the Yankees’ last four night games.
• Anthony Volpe has recorded at least one hit in each of his 14 previous appearances against the Twins after playing the previous day.
• Jose Caballero ranks 1st in the league in Steals (46) this season.

Matchup/League Facts

• The Twins rank T3rd in the league for walks allowed this season (431).
• The Twins rank 25th in the league for opponent batting average this season (.259).
• The Yankees rank 1st in the league for runs scored this season (774).
• The Yankees rank 1st in the league for home runs this season (254).

Twins vs Yankees Prediction

The Twins just don’t string wins together, and Matthews isn’t a pitcher I’m backing against this Yankees lineup. Matthews has an ERA over 5 on the season along with a 1.46 WHIP, and he’s allowed 41 hits and 18 earned runs in his last 36 innings. Schlittler has been solid for a rookie overall, and he has a 1.99 ERA and .195 allowed batting average in 22.2 road innings. I trust the Yankees more in this spot. Give me the Yanks.