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Twins vs Yankees Prediction 9/16/26 MLB Picks Today

NY Yankees (88-63) vs. Minnesota Twins (70-81)
September 16, 2026 1:40 pm EDT
The Line: Minnesota Twins 129 / NY Yankees -155; Over/Under: 8
(Get latest betting odds)

In this article we will formulate a Twins vs Yankees prediction for this MLB game on Wednesday, September 16th at Target Field in Minneapolis, Minnesota. Let’s take a look at the prediction for this MLB matchup. 

Minnesota Twins Betting Preview

The Minnesota Twins are 70-81 this season after they lost the first two games by scores of 3-8 and 1-8. In game two, Minnesota cut the deficit to 2-1 in the second inning, but failed to score over the last seven innings in the loss. The Twins recorded seven hits and they committed one error in the game, while they were led by Rodriguez, who went 2-3 with one RBI. Ober allowed nine hits and three earned runs over 5.1 innings for the loss, while Morris allowed one earned run in relief. Prior to this series, Minnesota lost two out of three against the Guardians and two out of three against the Tigers. 

This season, Minnesota has a 4.70 ERA with a 1.38 WHIP and a .252 opponent batting average, while they have scored 687 runs with a .243 batting average and a .317 on base percentage. Byron Buxton has led the Twins with 25 home runs and 46 RBIs, while Josh Bell has added 20 home runs and 87 RBIs. The projected starting pitcher for Minnesota is Zebby Matthews, who is 9-10 with a 4.98 ERA and a 1.27 WHIP over 119.1 innings pitched this season. 

New York Yankees Betting Preview

The New York Yankees are 88-63 this year after they won game two by a score of 8-1 on Tuesday. New York took the lead in the third inning and added four more in the sixth to pull away with the win. The Yankees recorded 14 hits in the game and they were led by Jones, who went 1-5 with one home run and three RBIs. Fried allowed six hits and one earned run over 7.0 innings for the win, while Yarbrough threw two relief innings. Prior to this series, New York won two out of three against the Mets and all three against the Rockies. 

This season, New York has a 3.21 ERA with a 1.16 WHIP and a .222 opponent batting average, while they have scored 693 runs with a .236 batting average and a .312 on base percentage. Ben Rice has led the Yankees with 38 home runs and 92 RBIs, while Cody Bellinger has added 16 home runs and 71 RBIs. The projected starting pitcher for New York is Carlos Rodon, who is 6-3 with a 2.94 ERA and a 1.12 WHIP over 70.1 innings pitched this year. 

Why the Minnesota Twins will win

  • The Twins have won each of their last six day games against AL East opponents.
  • The Yankees have lost each of their last four day games against AL Central opponents.
  • The Twins have covered the run line in each of their last six day games against AL East opponents.
  • The Yankees have failed to cover the run line each of their last four day games against AL Central opponents that held a losing record.
  • The Twins have won the first inning in six of their last seven day games against AL East opponents.
  • The Twins have led after 5 innings in six of their last seven day games against AL East opponents.
  • The Twins have led after 3 innings in each of their last seven day games against AL East opponents.

Why the New York Yankees will win

  • The Yankees have won nine of their last 10 games against teams that held a losing record.
  • The Twins have lost each of their last four home games against AL East opponents that held a winning record.
  • The Twins have failed to cover the run line in each of their last six games.
  • The Yankees have covered the run line in each of their last six road games after playing the previous day.
  • The Yankees have led after 3 innings in each of their last four games as favorites against AL Central opponents.
  • The Yankees have won the first inning in three of their last four games at Target Field.
  • The Yankees have led after 5 innings in nine of their last 10 games against opponents that held a losing record.

Total Runs Facts

  • Each of the Yankees’ last seven games against AL opponents have gone OVER the total runs line.
  • Each of the last four games between the Yankees and Twins at Target Field have gone OVER the total runs line.
  • There has been at least one run scored in the first inning in each of Zebby Matthews’ last eight appearances as a starter.
  • There has been no run scored during the first inning in each of Carlos Rodon’s last four road appearances as a starter.

Minnesota Twins Player Prop Facts

  • Josh Bell has hit a home run in three of his last four home appearances against AL East opponents that held a winning record.
  • Zebby Matthews has recorded a win in each of his last three home appearances.
  • Zebby Matthews has recorded five or more strikeouts in 10 of his last 13 appearances against AL opponents that held a winning record.
  • Kody Clemens has recorded at least one hit in each of the Twins’ last 10 Wednesday games.

New York Yankees Player Prop Facts

  • Austin Wells has hit a home run in each of his last two appearances.
  • Carlos Rodon has recorded a win in eight of his last 10 appearances with his team as a favorite against the Twins .
  • Cody Bellinger has recorded at least one hit in each of his last 12 road appearances after playing the previous day.
  • Luis Garcia ranks 3rd amongst qualified players for Slugging Percentage (.543) this season.

Matchup/League Facts

  • The Twins rank 26th in the league for ERA this season (4.70).
  • The Twins rank 26th in the league for runs allowed this season (761).
  • The Yankees rank 1st in the league for home runs this season (209).
  • The Yankees rank 1st in the league for ERA this season (3.21).

Twins vs Yankees Prediction 

New York comes into this matchup on a three game winning streak and they have scored 6+ runs in three of their last five. The Yankees are 46-31 on the road this year, while the Twins are 39-38 at home. Minnesota has dropped four of their last five games and they have allowed 8+ runs in three straight. The Twins are starting Matthews, who has allowed nine earned runs in his last 7.1 innings, while Rodon has allowed two earned runs or fewer in five straight. Take the Yankees -1 here. 

David Racey's Free Pick: Yankees -1

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David Racey

David started writing about sports in 2015, but sports has been his passion for as long as he can remember. David spends most of his free time watching pretty much anything sports related from Baseball to Tennis and everything in between. David likes to analyze statistics and recent results to form an unbiased opinion on whatever game he is breaking down. Follow David on Twitter at @itsyerboi41

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