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Washington Nationals vs San Diego Padres Prediction 7-19-25 Picks

San Diego Padres (53-44) vs. Washington Nationals (38-59)
July 19, 2025 10:45 pm EDT
The Line: Washington Nationals +128 / San Diego Padres -156; Over/Under: 9
(Get latest betting odds)

The San Diego Padres and the Washington Nationals meet Saturday in MLB action from Nationals Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a San Diego Padres vs. Washington Nationals prediction.

Starting Pitching Matchup

The San Diego Padres will send out Yu Darvish for the start here, and Darvish is 0-1 with a 6.48 ERA and 7 strikeouts this season. Mitchell Parker will get the start for the Nationals here and is 5-10 with a 5.12 ERA and 66 strikeouts this season.

San Diego Padres Recap

The San Diego Padres come into this game looking to build on their 7-2 win over the Nationals from Friday’s matchup to sit at 53-44 on the year. After this series, the Padres will head on the road for a series against the Miami Marlins.

Padres Win 4 Of Their Last 5 Games

Manny Machado has 108 hits, including a team-high 22 doubles, 18 home runs, 60 RBIs, and 8 stolen bases, while Fernando Tatis Jr. has 97 hits with a team-high 16 home runs and 42 RBIs, along with 22 stolen bases of his own this season. Luis Arraez has added 104 hits with 17 doubles, 4 triples, 5 home runs, and 35 RBIs, while Jackson Merrill’s added 65 hits with 7 home runs and 32 RBIs as well. Xander Bogaerts also has 20 doubles and 16 stolen bases this season. Gavin Sheets also has 15 doubles, 14 home runs, and 50 RBIs this season.

Why the San Diego Padres will win

    • The Padres have won 11 of their last 12 night games against NL East opponents that held a losing record.
    • The Nationals have lost nine of their last 10 games.
    • The Nationals have failed to cover the run line in each of their last nine home games against National League opponents.
    • The road team has covered the run line in each of the last seven games between the Padres and Nationals.

San Diego Padres Player Prop Facts

  • Yu Darvish has recorded a win in each of his last five road appearances against opponents that held a losing record.
  • Yu Darvish has recorded six or more strikeouts in each of his last 15 Saturday appearances in night games.
  • Manny Machado has hit a home run in each of the Padres’ last three night games.
  • Jose Iglesias has recorded at least one hit in each of his last 15 road appearances against NL East opponents.
  • Manny Machado ranks T6th in the league in Hits (108) this season.

Washington Nationals Recap

The Washington Nationals come into this game looking to rebound from the loss at the hands of the Padres on Friday to slip to 38-59 on the year. After this series, the Nationals will take on the Cincinnati Reds at home.

Nationals Lose 5 In A Row

Keibert Ruiz has 63 hits with 12 doubles and a pair of home runs with 25 RBIs, while James Wood has 99 hits with 19 doubles and a team-high 24 home runs along with 69 RBIs and 13 stolen bases, while also putting up 119 strikeouts. Nathaniel Lowe has 85 hits with 14 doubles and 61 RBIs, along with 14 home runs and 112 strikeouts. CJ Abrams has 13 home runs and 35 RBIs along with 20 doubles and 20 stolen bases, while Luis Garcia Jr. has 20 doubles and 8 stolen bases of his own this season. Dylan Crews has also logged 11 stolen bases this season.

Why the Washington Nationals will win

  • The Padres have lost seven of their last eight games as favorites against National League opponents following a win.
  • The Nationals have won seven of their last eight Saturday games as underdogs against NL West opponents.
  • The Padres have failed to cover the run line in each of their last 11 games as favorites following a win.
  • The Nationals have covered the run line in each of their last 12 Saturday games as underdogs against NL West opponents.

Washington Nationals Player Prop Facts

  • CJ Abrams has hit a home run in three of the Nationals’ last five night games against NL West opponents that held a winning record.
  • Amed Rosario has recorded a Double in three of his last four appearances with the Nationals as home underdogs against NL West opponents.
  • Amed Rosario has recorded at least one hit in 18 of his last 19 appearances at Nationals Park against opponents that held a winning record.
  • James Wood ranks T9th in the league in Home Runs (24) this season.

Total Runs Facts

  • Each of the Nationals’ last seven home games have gone OVER the total runs line.
  • Four of the Padres’ last five night games against NL East opponents have gone UNDER the total runs line.

San Diego Padres vs. Washington Nationals Prediction

I’m on the Padres here. I get the case to be made for a home underdog in some spots, but the Nationals just are not playing well enough right now to justify taking a shot on them even at this price. Mitchell Parker has been struggling, and the Padres, as of late, have picked up their play against left-handed pitching in a lot of their recent matchups. Give me the Padres here.

Chris Ruffolo's Free Pick: San Diego Padres -156

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Chris Ruffolo

Chris joined the Sports Chat Place team in August 2016 and has a proven system that combines multiple analytical and situational statistics and trends to give out thousands of winning picks over the last three years with winning records across all of the top leagues, Follow Chris Ruffolo on Twitter @ruffthepickdawg

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