White Sox vs Astros Prediction 5/2/25 MLB Picks Today

The Houston Astros and Chicago White Sox meet Friday in MLB action at Rate Field. Here’s a White Sox vs Astros Prediction. This article will include a White Sox vs Astros Pick.

Houston Astros Betting Preview

The Houston Astros are 16-14 on the year and play the Brewers, Reds, and Royals next. The Houston Astros are batting .236 on the season, have a .310 OBP, and a .357 slugging percentage. The Houston Astros’ pitching staff has a 3.23 ERA and a 1.08 WHIP. Jose Altuve leads the Houston Astros with 32 hits and 14 RBI, while Jeremy Pena and Isaac Paredes have combined for 59 hits and 26 RBI.

Framber Valdez gets the ball for the Houston Astros, and he is 1-3 with a 4.00 ERA and 31 strikeouts this season. Valdez is 4-2 with a 2.49 ERA and 42 strikeouts in his career against the Chicago White Sox.

Chicago White Sox Betting Preview

The Chicago White Sox are 8-23 on the year and play the Royals, Marlins, and Reds next. The Chicago White Sox are batting .213 on the season, have a .291 OBP, and a .329 slugging percentage. The Chicago White Sox pitching staff has a 4.04 ERA and a 1.36 WHIP. Lenyn Sosa leads the Chicago White Sox with 29 hits and 8 RBI, while Miguel Vargas and Brooks Baldwin have combined for 45 hits and 25 RBI.

Jonathan Cannon gets the ball for the Chicago White Sox, and he is 1-3 with a 4.50 ERA and 27 strikeouts this season. This will be Cannon’s second career game against the Houston Astros.

Why the Chicago White Sox will win

• The White Sox have won four of their last five games as home underdogs against AL West opponents following a win.
• The Astros have lost each of their last five games against teams that held a losing record.
• The White Sox have covered the run line in each of their last six games as underdogs against AL West opponents following a win.
• The Astros have failed to cover the run line each of their last five road games against teams that held a losing record.

Why the Houston Astros will win

• The White Sox have lost 12 of their last 13 games at Rate Field against American League opponents that held a winning record.
• The Astros have won seven of their last eight road games following a loss.
• The Astros have covered the run line in each of their last seven road games following a home loss.
• The White Sox have failed to cover the run line in eight of their last nine games at Rate Field against teams that held a winning record.
• The Astros have led after 3 innings in three of their last four games at Rate Field.

Chicago White Sox Player Prop Facts

• Michael A. Taylor has hit a home run in two of his last three appearances against the Astros.
• Luis Robert has recorded at least one RBI in four of the White Sox’s last five games as underdogs.
• Andrew Vaughn has recorded at least one Single in seven of the White Sox’s last eight night games against AL opponents that held a winning record.
• Miguel Vargas has recorded at least one hit in each of the White Sox’s last eight games.
• Andrew Benintendi has scored at least one run in four of his last five home appearances after playing the previous day.

Houston Astros Player Prop Facts

• Isaac Paredes has hit a home run in two of his last three road appearances against the White Sox.
• Yordan Alvarez has recorded at least one RBI in 11 of his last 12 appearances with the Astros as favorites against the White Sox.
• Jose Altuve has scored at least one run in each of the Astros’ last four games against the White Sox.
• Jeremy Pena has recorded at least one Single in 12 of the Astros’ last 13 games as favorites against AL opponents.
• Yordan Alvarez has recorded at least one hit in each of his last 11 appearances with the Astros as favorites against the White Sox.

White Sox vs Astros Prediction

Valdez has had a couple of stinkers lately, but he’s still allowed two or fewer runs in four of his six starts. Valdez has been better more times than not; he’s getting his ground balls, and he has 31 strikeouts in 36 innings. Cannon has allowed three or more runs in four of his last five starts, and he’s walked 14 in his last 27 innings.

Overall, this game has to do with the White Sox being the worst team in baseball over the last three combined seasons and holding no betting value whatsoever. Even with a win yesterday, the White Sox have won two straight games just once this season. As I’ve said a lot this season, I want nothing to do with the White Sox, and one win doesn’t change anything. Of course, I’ll lay the RL to shave down the expensive price.