White Sox vs Astros Prediction 5/4/25 MLB Picks Today

In this article, we will formulate a White Sox vs Astros prediction for this MLB game on Sunday, May 4, at Rate Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup.

Houston Astros Betting Preview

The Houston Astros (17-15, 6-8 Away) swept the Blue Jays, lost to the Royals, and beat the Tigers before this series in Chicago. The Astros lost Game 1 but responded with an 8-3 victory in Game 2, even though the White Sox took a 3-0 lead early on. Jake Meyers erupted for a career-high seven RBI, becoming the first Astros player to have a home run, a triple, and a double in a single game. Hunter Brown got the win after allowing three runs on four hits with nine strikeouts and three walks over 6.0 innings of work.

This year, the Astros average 3.87 runs per game (20th in the MLB) on a .238/.310/.359 triple-slash. When it comes to pitching, the Astros’ staff has a 3.36 ERA (5th) and 1.10 WHIP (2nd). Yordan Alvarez leads the Astros with a .210 batting average, three home runs, and 18 RBI this season.

Lance McCullers Jr. will take the mound for the Astros on Sunday. The 31-year-old right-hander will have his season debut after coming back from IL and a forearm injury.

Chicago White Sox Betting Preview

The Chicago White Sox (9-24, 6-11 Home) won just one series this season, and it was in mid-April against the Red Sox. The White Sox won two in a row for the second time this year as they beat the Brewers in Game 3 of that series and opened this one against the Astros with a 7-3 win. However, Houston answered with an 8-3 victory in Game 2. Andrew Vaughn led the team with two RBI, while Davis Martin pitched for 5.0 innings in a no-decision, allowing three runs on eight hits with five strikeouts and no walks. Fraser Ellard took the loss.

This season, the White Sox average 3.62 runs per game (24th in the MLB) on a .216/.294/.333 slash line. Regarding pitching, the White Sox’s staff has a 4.01 ERA (17th) and 1.35 WHIP (22nd). Luis Robert Jr. leads the White Sox with a .182 batting average, five home runs, and 14 RBI this season.

The projected starting pitcher for the White Sox is Bryse Wilson, who is 0-1 in one start this season, with a 5.00 ERA and 1.78 WHIP in 18.0 innings.

Total Runs Facts

• Each of the Astros’ last six games have gone OVER the total runs line.
• Four of the White Sox’s last five games have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the White Sox’s last seven games as underdogs.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Astros’ last four games.

Matchup/League Facts

• The White Sox rank 28th in the league for hits this season (230).
• The White Sox rank T28th in the league for triples this season (1).
• The Astros rank 4th in the league for opponent batting average this season (.214).
• The Astros rank 4th in the league for runs allowed this season (114).

White Sox vs Astros Prediction

The Astros won six of the previous ten H2H encounters, including three of the last four. Lance McCullers Jr. hasn’t pitched since 2022, and I am not sure how he’ll look on Sunday. The rust will be there, that’s certain, so I am backing the White Sox to score multiple runs off McCullers Jr. Bryse Wilson, on the other hand, is a reliever and I don’t think he’ll pitch for more than 3.0 innings, but I am sure the Astros are going to get him early on. Wilson allowed a .353 BA in 34 at-bats against the Astros. Seven of Chicago’s last ten games went Over. I am going with another Over in this one.