White Sox vs Cardinals Prediction 6/18/25 MLB Picks Today

In this article, we will formulate a White Sox vs Cardinals prediction for this MLB game on Wednesday, June 18th at Rate Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup. 

Chicago White Sox Betting Preview

The Chicago White Sox are 23-50 this year after they lost game one by a score of 12-2 on Tuesday night. Chicago led 1-0 in the first inning, but they allowed 12 of the next 13 runs in the blowout loss. The White Sox recorded six hits and they committed two errors in the game, while they were led by Capra and Quero, who both had one RBI in the loss. Chicago started Smith, who allowed six hits and five earned runs over 4.1 innings for the loss, while four relievers all allowed at least one earned run. 

Prior to this series, the White Sox lost all three games against the Rangers and two out of three against the Astros. Chicago has lost six games in a row, and they are currently last in the AL Central standings. The Chicago pitching staff has a 4.23 ERA with a 1.41 WHIP and a .255 opponent batting average, while the offense has scored 250 runs with a .222 batting average and a .293 on-base percentage this season. Miguel Vargas has led Chicago with 10 home runs and 31 RBIs, while Luis Robert has added six home runs and 28 RBIs this year. The projected starting pitcher for Chicago is Sean Burke, who is 3-7 with a 4.71 ERA and a 1.44 WHIP over 70.2 innings pitched this year. 

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 38-35 this season after they won game one in blowout fashion on Tuesday night. St. Louis had their lead cut to 6-2 in the fifth inning, but they scored the last six runs in the game for the easy win. The Cardinals recorded 13 hits in the game, and they were led by Herrera, who went 2-5 with four RBIs in the win. St. Louis started Liberatore, who allowed five hits and two earned runs over 6.0 innings for the win, while O’Brien and Granillo pitched three scoreless innings in relief. 

Prior to this series, the Cardinals lost three out of four against the Brewers and all three games against the Blue Jays. St. Louis has lost seven of their last nine games, and they are currently third in the NL Central standings. The St. Louis pitching staff has a 3.97 ERA with a 1.27 WHIP and a .254 opponent batting average, while their offense has scored 340 runs with a .257 batting average and a .328 on-base percentage this season. Wilson Contreras has led St. Louis with nine home runs, 45 RBIs, and three stolen bases, while Nolan Arenado has added eight home runs and 36 RBIs this year. The projected starting pitcher for St. Louis is Sonny Gray, who is 7-2 with a 3.84 ERA and a 1.18 WHIP over 79.2 innings pitched this season. 

Why the Cardinals will beat the White Sox

• The White Sox have lost each of their last 13 night games against National League opponents that held a winning record.
• The Cardinals have won each of their last nine Wednesday night games.
• The Cardinals have covered the run line in eight of their last nine night games against teams that held a losing record.
• The White Sox have failed to cover the run line in seven of their last eight night games against National League opponents that held a winning record.
• The White Sox have trailed after 3 innings in seven of their last eight night games against National League opponents that held a winning record.
• The White Sox have trailed after 5 innings in eight of their last nine night games against National League opponents that held a winning record.

Total Runs Facts

• Each of the Cardinals’ last 10 night games against American League opponents have gone OVER the total runs line.
• Eight of the White Sox’s last 10 home games have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Cardinals’ last eight games against American League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the White Sox’s last eight games as home underdogs against NL Central opponents.

Chicago White Sox Player Prop Facts

• Miguel Vargas has hit at least one home run in seven of his last 10 appearances against NL Central opponents that held a winning record.
• Andrew Benintendi has recorded at least one hit in each of his last seven appearances against NL Central opponents that held a winning record.
• Miguel Vargas has recorded at least one RBI in eight of his last 10 appearances against NL Central opponents that held a winning record.
• Miguel Vargas has recorded a Double in each of the White Sox’s last four games against NL opponents.
• Miguel Vargas has scored at least one run in each of the White Sox’s last five games.

St. Louis Cardinals Player Prop Facts

• Alec Burleson has hit a home run in each of the Cardinals’ last two road games against AL Central opponents.
• Sonny Gray has recorded six or more strikeouts in each of his last 10 appearances with his team as a favorite against AL opponents.
• Nolan Arenado has recorded at least one hit in each of his last 10 Wednesday night appearances.
• Willson Contreras has recorded at least one RBI in eight of the Cardinals’ last nine games against AL opponents.
• Brendan Donovan has recorded a Double in three of the Cardinals’ last four road games against AL Central opponents.
• Willson Contreras has scored at least one run in each of the Cardinals’ last five games against the White Sox.
• Sonny Gray has recorded a win in seven of his last eight appearances with the Cardinals as favorites against AL opponents.

White Sox vs Cardinals Prediction 

St. Louis was able to pick up an easy win to start this series on Tuesday night, but they have struggled over the last few series. The Cardinals are 16-21 on the road this year, while the White Sox are 16-19 at home. Chicago has lost six games in a row, and they have scored two runs or fewer in three of their last four. The White Sox are starting Burke, who has allowed two earned runs or fewer in three of his last four starts. The Cards are going with Gray, who has allowed zero earned runs in three of his last five. Take the Cardinals -1.5 in this contest.