White Sox vs Cardinals Prediction 6/19/25 MLB Picks Today

The St. Louis Cardinals and Chicago White Sox meet Thursday in a MLB doubleheader at Rate Field. Here’s a White Sox vs Cardinals Prediction. This article will include a White Sox vs Cardinals Pick.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 38-35 on the year and play the Reds, Cubs, and Guardians next. The St. Louis Cardinals are batting .257 on the season, have a .328 OBP, and a .393 slugging percentage. The St. Louis Cardinals’ pitching staff has a 3.97 ERA and a 1.27 WHIP. Brendan Donovan leads the St. Louis Cardinals with 83 hits and 27 RBI, while Willson Contreras and Nolan Arenado have combined for 127 hits and 81 RBI.

Erick Fedde and Michael McGreevy get the ball for the St. Louis Cardinals.

Chicago White Sox Betting Preview

The Chicago White Sox are 23-50 on the year and play the Blue Jays, Diamondbacks, and Giants next. The Chicago White Sox are batting .222 on the season, have a .293 OBP, and a .342 slugging percentage. The Chicago White Sox pitching staff has a 4.23 ERA and a 1.41 WHIP. Miguel Vargas leads the Chicago White Sox with 62 hits and 31 RBI, while Lenyn Sosa and Chase Meidroth have combined for 106 hits and 26 RBI.

Sean Burke and Mike Vasil get the ball for the Chicago White Sox.

Why the Chicago White Sox will win

• The White Sox have won each of their last seven games as home underdogs following a home loss.
• The Cardinals have lost each of their last four games as road favorites against American League opponents following a win.
• The Cardinals have failed to cover the run line in each of their last nine games as favorites against AL Central opponents following a win.
• The White Sox have covered the run line in each of their last nine games following a home loss.
• The Cardinals have lost the first inning in each of their last four games against AL Central opponents.
• The White Sox have led after 3 innings in each of their last six Thursday games against National League opponents that held a winning record.
• The Cardinals have trailed after 5 innings in seven of their last eight games against American League opponents.

Why the St. Louis Cardinals will win

• The White Sox have lost 18 of their last 19 home games against NL Central opponents.
• The favorites have won each of the White Sox’s last six games.
• The road team has covered the run line in eight of the Cardinals’ last nine games.
• The White Sox have failed to cover the run line in seven of their last eight games as home underdogs on the first leg of a doubleheader.
• The White Sox have trailed after 3 innings in each of their last five games against NL Central opponents.
• The Cardinals have led after 5 innings in seven of their last eight games against the White Sox.

Chicago White Sox Player Prop Facts

• Miguel Vargas has hit at least one home run in three of the White Sox’s last four day games against NL Central opponents that held a winning record.
• Josh Rojas has recorded at least one hit in 14 of his last 15 home appearances after not playing the previous day.
• Miguel Vargas has recorded a Double in each of the White Sox’s last four games against NL opponents.
• Miguel Vargas has scored at least one run in each of the White Sox’s last five games.
• Miguel Vargas has recorded at least one RBI in each of the White Sox’s last four day games against NL Central opponents that held a winning record.
• Luis Robert ranks T4th in the league in Steals (21) this season.

St. Louis Cardinals Player Prop Facts

• Alec Burleson has hit a home run in each of the Cardinals’ last two road games against AL Central opponents.
• Erick Fedde has recorded five or more strikeouts in four of his last five road appearances.
• Alec Burleson has recorded at least one hit in each of the Cardinals’ last seven road games.
• Brendan Donovan has recorded a Double in three of the Cardinals’ last four road games against AL Central opponents.
• Brendan Donovan has scored at least one run in nine of his last 10 appearances after not playing the previous day.
• Willson Contreras has recorded at least one RBI in eight of the Cardinals’ last nine games against AL opponents.
• Brendan Donovan ranks 6th amongst qualified players for Batting Average (.323) this season.

White Sox vs Cardinals Prediction

Game 1 Prediction: It’s hard to trust the White Sox from game to game, as they’re one of the worst teams in baseball. It’s even tougher when they don’t have the edge pitching-wise. Burke has been hittable this season, and he’s allowed 15 hits and nine runs in his last 10.2 innings. Fedde has a 3.65 ERA and 1.28 WHIP on the season, and he’s allowed five runs in his last 16.2 innings. Fedde has also been better on the road, where he has a 3.13 ERA and .211 allowed batting average in 46 innings. Give me the Cardinals in game 1.

Game 2 Prediction: The Cardinals are probably the right play, but it’s hard to sweep a doubleheader. McGreevy has also pitched just 11.2 innings this season, and that’s not enough of a sample size. Vasil is going deeper into games lately, and he’s allowed nine hits and two runs in his last 11 innings. In 27.1 home innings, Vasil has a 1.65 ERA and a .206 allowed batting average. The White Sox have the edge on the mound in this game. Give me the White Sox.