White Sox vs Cubs Prediction 7-26-25 MLB Picks

The Chicago Cubs and Chicago White Sox meet Saturday in MLB action at Sutter Health Park. Here’s a White Sox vs Cubs Prediction. This article will include a White Sox vs Cubs Pick.

Chicago Cubs Betting Preview

The Chicago Cubs are 60-43 on the year and play the Brewers, Orioles, and Reds next. The Chicago Cubs are batting .256 on the season, have a .324 OBP, and a .445 slugging percentage. The Chicago Cubs pitching staff has a 3.93 ERA and a 1.23 WHIP. Nico Hoerner leads the Chicago Cubs with 108 hits and 41 RBI, while Pete Crow-Armstrong and Kyle Tucker have combined for 209 hits and 132 RBI.

Cade Horton gets the ball for the Chicago Cubs, and he is 3-3 with a 4.04 ERA and 47 strikeouts this season. This will be Horton’s second career game against the Chicago White Sox.

Chicago White Sox Betting Preview

The Chicago White Sox are 38-66 on the year and play the Phillies, Angels, and Mariners next. The Chicago White Sox are batting .227 on the season, have a .300 OBP, and a .360 slugging percentage. The Chicago White Sox pitching staff has a 4.08 ERA and a 1.38 WHIP. Miguel Vargas leads the Chicago White Sox with 84 hits and 41 RBI while Lenyn Sosa and Chase Meidroth have combined for 158 hits and 52 RBI.

Aaron Civale gets the ball for the Chicago White Sox, and he is 2-6 with a 4.76 ERA and 42 strikeouts this season. Civale is 0-0 with a 1.61 ERA and 16 strikeouts in his career against the Chicago Cubs.

Why the Chicago White Sox will win

• The White Sox have won each of their last five games as underdogs against National League opponents.
• The Cubs have lost three of their last four games as favorites.
• The White Sox have covered the run line in each of their last eight games.
• The Cubs have failed to cover the run line in six of their last seven night games against AL Central opponents.
• The Cubs have lost the first inning in four of their last five road games against AL Central opponents.
• The Cubs have trailed after 5 innings in each of their last four road night games.
• The Cubs have trailed after 3 innings in each of their last six road night games.

Why the Chicago Cubs will win

• The White Sox have lost 19 of their last 20 night games against National League opponents that held a winning record.
• The Cubs have won eight of their last nine games against the White Sox.
• The Cubs have covered the run line in each of their last seven games as road favorites against American League opponents following a road loss.
• The White Sox have failed to cover the run line each of their last seven Saturday night games against teams that held a winning record.
• The Cubs have won the first inning in each of their last five Saturday games against American League opponents.
• The White Sox have trailed after 5 innings in each of their last seven Saturday night games against opponents that held a winning record.
• The White Sox have trailed after 3 innings in six of their last seven games against NL Central opponents that held a winning record.

Chicago White Sox Player Prop Facts

• Andrew Benintendi has recorded at least one hit in each of his last 10 appearances against NL Central opponents that held a winning record.
• Aaron Civale has recorded four or more strikeouts in each of his last eight appearances with his team as an underdog against NL opponents.
• Austin Slater has hit a home run in each of the White Sox’s last two games as home underdogs.
• Michael A. Taylor has recorded a Double in each of his last five appearances with the White Sox as underdogs against NL opponents.
• Aaron Civale has recorded a win in three of his last four appearances against NL Central opponents.
• Luis Robert ranks T8th in the league in Steals (26) this season.

Chicago Cubs Player Prop Facts

• Kyle Tucker has hit a home run in each of his last four Saturday night appearances with his team as a favorite.
• Nico Hoerner has recorded at least one hit in each of the Cubs’ last 10 games as road favorites.
• Pete Crow-Armstrong ranks 5th in the league in Steals (28) this season.

White Sox vs Cubs Prediction

We’ve made a killing blindly fading the White Sox over the years, but six wins in their last seven games is worth looking at. Horton has been hittable this season, especially on the road, where he has a 6.35 ERA and .313 allowed batting average in 28.1 innings. This winning stretch is unlikely going to continue for much longer, but the White Sox have made money hand over fist in the second half. I’ll take the White Sox on Saturday.