White Sox vs Diamondbacks Prediction 4/22/26 MLB Picks Today

In this article, we will formulate a White Sox vs Diamondbacks Prediction for this MLB matchup on Wednesday, April 22^nd in the second game of this series. Let’s take a look at the prediction for this MLB matchup.

Arizona Diamondbacks Preview

The Arizona Diamondbacks have a 13-10 record this season and are sitting in the third place of the NL West. They have a 7-4 home record and are coming off a 5-11 home loss against the White Sox. Their previous three games were a 4-10 home loss and a 6-2 home win against the Blue Jays, and an 8-5 road win against the Orioles.

The Diamondbacks have a .242 batting average this season, .297 OBP and .401 Slugging percentage. Arizona’s pitching staff has a 4.32 ERA and 1.30 WHIP. Corbin Carroll is the team’s best hitter with a .288 batting average, also leading the team in RBI with 16. Ketel Marte adds a team‑high 4 home runs.

Eduardo Rodriguez (L) is the projected starting pitcher for the Diamondbacks, and he has a 1-0 record, 1.96 ERA and 1.22 WHIP.

Chicago White Sox Preview

The Chicago White Sox have a 9-14 record this season and are sitting in the fourth place of the AL Central. They have a 6-8 away record and are coming off an 11-5 road win against the Diamondbacks. Their previous three games were a 7-4 road win, a 6-7 road loss, and a 9-2 road win against the Athletics.

The White Sox have a .218 batting average this season, .312 OBP and .376 Slugging percentage. Chicago’s pitching staff has a 4.84 ERA and 1.46 WHIP. Chase Meidroth is the team’s best hitter with a .253 batting average. Munetaka Murakami leads the team in RBI with 17, also adding a team‑high 9 home runs.

Anthony Kay (L) is the projected starting pitcher for the White Sox, and he has a 1-0 record, 2.60 ERA and 1.27 WHIP.

The Chicago White Sox @ Arizona Diamondbacks Betting Trends: April 22, 2026

• Probable Starting Pitcher: Eduardo Rodriguez      Record this season: 1-0      ERA: 1.96
• Home Record: 0-0
• Last 5 against White Sox: 3-0

Why the Arizona Diamondbacks will win

• The White Sox have lost eight of their last nine games following a road win.
• The Diamondbacks have won six of their last seven games against the White Sox following a loss.
• The Diamondbacks have covered the run line in six of their last seven games against AL Central opponents.
• The White Sox have failed to cover the run line in six of their last seven games against the Diamondbacks following a win.
• The White Sox have trailed after 5 innings in each of their last six Wednesday road games.
• The Diamondbacks have won the first inning in three of their last four night games against the White Sox.

• Probable Starting Pitcher: Anthony Kay      Record this season: 1-0      ERA: 2.60
• Road Record: 1-0
• Last 5 against Diamondbacks: –

Why the Chicago White Sox will win

• The White Sox have won four of their last five games as road underdogs.
• The Diamondbacks have lost each of their last four Wednesday night games as favorites against American League opponents.
• The road team has covered the run line in each of the White Sox’s last eight games.
• The Diamondbacks have failed to cover the run line in each of their last eight games following a home loss.
• The White Sox have led after 5 innings in each of their last four games.
• The White Sox have won the first inning in each of their last three games against opponents that held a winning record.
• The White Sox have led after 3 innings in each of their last five games.

Total Runs Facts

• Seven of the White Sox’s last eight games have gone OVER the total runs line.
• Five of the last six games between the White Sox and Diamondbacks have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the last six games between the White Sox and Diamondbacks.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in 10 of the White Sox’s last 11 night games against NL West opponents.

Arizona Diamondbacks Player Prop Facts

• Ildemaro Vargas has hit a home run in each of the Diamondbacks’ last two games as favorites against AL Central opponents.
• Eduardo Rodriguez has recorded a win in five of his last six appearances against AL Central opponents that held a losing record.
• Eduardo Rodriguez has recorded five or more strikeouts in each of his last 13 appearances against AL opponents that held a losing record.
• Ildemaro Vargas has recorded at least one hit in each of his last 21 appearances in night games.
• Geraldo Perdomo ranks T10th in the league in Steals (6) this season.

Chicago White Sox Player Prop Facts

• Miguel Vargas has hit a home run in three of the White Sox’s last four games against opponents that held a winning record.
• Andrew Benintendi has recorded at least one hit in each of his seven previous road appearances against the Diamondbacks.
• Munetaka Murakami ranks T2nd in the league in Home Runs (9) this season.

Matchup/League Facts

• The Diamondbacks rank T2nd in the league for doubles this season (48).
• The Diamondbacks rank 2nd in the league for triples this season (6).
• The White Sox rank 29th in the league for batting average this season (.218).
• The White Sox rank T28th in the league for hits this season (165).

White Sox vs Diamondbacks Prediction

Both teams are tied 4-4 in their last 8 meetings and are 2-2 in their last four meetings in Arizona.

In this White Sox vs Diamondbacks Prediction, the Diamondbacks are coming as -150 home favorites. The White Sox won yesterday and have now back-to-back wins with 18 runs scored, while the Dbacks have dropped two straight, with 21 earned runs combined. Even though both pitchers are looking good so far, Chicago has the 28^th bullpen ERA in baseball and both teams are excellent against left-handed pitching, scoring 10.3 runs/9 against lefties and are 11-2 to the over in their last 13 games combined. Ride the hot bats and take the over 9.5 in this one.